Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Thorsten, Wiech"'
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-4 (2024)
Abstract Background Membranoproliferative glomerulonephritis is a rare entity which can be a result from autoimmune diseases, caused by various medications and infections. Case presentation We herein present the case of a 62-year-old male patient who
Externí odkaz:
https://doaj.org/article/5e2dbc0f17e6400ea5d2f08caaeca4f1
Autor:
Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu
Externí odkaz:
https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607
Autor:
Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Little is known about the mechanistic significance of the ubiquitin proteasome system (UPS) in a kidney autoimmune environment. In membranous nephropathy (MN), autoantibodies target podocytes of the glomerular filter resulting in proteinuria
Externí odkaz:
https://doaj.org/article/cee0c8ae32e746e8ba523351dc7de044
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder often diagnosed after incidental finding of leukocytosis. Renal involvement is usually clinically silent. Symptomatic renal impairment due to CLL/small lymphocytic lymphoma (SLL) ce
Externí odkaz:
https://doaj.org/article/9ab3479adf244069b097aa882eced576
Autor:
Larissa Seifert, Gunther Zahner, Catherine Meyer-Schwesinger, Naemi Hickstein, Silke Dehde, Sonia Wulf, Sarah M. S. Köllner, Renke Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, Oliver Kretz, Anna Borodovsky, Sergey Biniaminov, Yanyan Wang, Hong Cheng, Friedrich Koch-Nolte, Peter F. Zipfel, Helmut Hopfer, Victor G. Puelles, Ulf Panzer, Tobias B. Huber, Thorsten Wiech, Nicola M. Tomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN
Externí odkaz:
https://doaj.org/article/c71d3e45f83243fc953b6a19b9d58113
Autor:
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular
Externí odkaz:
https://doaj.org/article/df3b8422c172486d90e70dad5e72e7ce
Case report: Early onset de novo FSGS in a child after kidney transplantation—a successful treatment
Autor:
Karla Carvajal Abreu, Sebastian Loos, Lutz Fischer, Lars Pape, Thorsten Wiech, Markus J. Kemper, Burkhard Tönshoff, Jun Oh, Raphael Schild
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundEarly onset de novo focal segmental glomerular sclerosis (FSGS) in the kidney allograft in patients without FSGS in the native kidney is a rare disorder in children. It usually occurs mostly beyond the first year after kidney transplantatio
Externí odkaz:
https://doaj.org/article/859ec1c8e80e4092951a0bffb6ba70ab
Autor:
Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M. Tomas, Elion Hoxha, Ulrich O. Wenzel, Tobias B. Huber, Thorsten Wiech, Jan-Eric Turner, Christian F. Krebs, Ulf Panzer
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Glucocorticoids remain a cornerstone of therapeutic regimes for autoimmune and chronic inflammatory diseases — for example, in different forms of crescentic glomerulonephritis — because of their rapid antiinflammatory effects, low cost, and wide
Externí odkaz:
https://doaj.org/article/6443c52a90ff43ecadb3bda903f06ac0
Autor:
Sarah Irmscher, Svante L. H. Zipfel, Luke D. Halder, Lia Ivanov, Andres Gonzalez-Delgado, Christoph Waldeyer, Moritz Seiffert, Fabian J. Brunner, Monika von der Heide, Ina Löschmann, Sonia Wulf, Darina Czamara, Nikolina Papac-Milicevic, Olaf Strauß, Stefan Lorkowski, Hermann Reichenspurner, Michael V. Holers, Nirmal K. Banda, Tania Zeller, Elisabeth B. Binder, Christoph J. Binder, Thorsten Wiech, Peter F. Zipfel, Christine Skerka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellula
Externí odkaz:
https://doaj.org/article/f4fef222f3624b56b6f873bb7fc7bb7a
Autor:
Emma Diletta Stea, Christine Skerka, Matteo Accetturo, Francesco Pesce, Thorsten Wiech, Andrea Hartman, Paola Pontrelli, Francesca Conserva, Giuseppe Castellano, Peter F. Zipfel, Loreto Gesualdo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Atypical hemolytic–uremic syndrome (aHUS) is a severe thrombotic microangiopathy in which kidney involvement is common. aHUS can be due to either genetic or acquired abnormalities, with most abnormalities affecting the alternative complement pathwa
Externí odkaz:
https://doaj.org/article/a8abfc2027b845809ec7ad62bf4efa1b