Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Thorsten, Lamla"'
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targe
Externí odkaz:
https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be
Autor:
Kolja Becker, Carina M. Weigelt, Holger Fuchs, Coralie Viollet, Werner Rust, Hannah Wyatt, Jochen Huber, Thorsten Lamla, Francesc Fernandez-Albert, Eric Simon, Nina Zippel, Remko A. Bakker, Holger Klein, Norbert H. Redemann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Retinopathies are multifactorial diseases with complex pathologies that eventually lead to vision loss. Animal models facilitate the understanding of the pathophysiology and identification of novel treatment options. However, each animal mod
Externí odkaz:
https://doaj.org/article/6aaa2e0a328d459892cb845548a66e42
Autor:
Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression usi
Externí odkaz:
https://doaj.org/article/5f71560143154c38951bffbfbcaeeb5e
Autor:
Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of thermogenic adipocytes is a strategy to combat metabolic diseases. Here the authors report that GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-s
Externí odkaz:
https://doaj.org/article/88ee4530cad64964a1bb8fbac9b2b659
Autor:
Jonas Weinmann, Sabrina Weis, Josefine Sippel, Warut Tulalamba, Anca Remes, Jihad El Andari, Anne-Kathrin Herrmann, Quang H. Pham, Christopher Borowski, Susanne Hille, Tanja Schönberger, Norbert Frey, Martin Lenter, Thierry VandenDriessche, Oliver J. Müller, Marinee K. Chuah, Thorsten Lamla, Dirk Grimm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Externí odkaz:
https://doaj.org/article/fcda7a44d2044540880d0f383706efd9
Autor:
Peng, Sun, Christina S, Bartlett, Chao, Zheng, Tammy, Bigwarfe, Joshuaine M, Grant, Margit, MacDougall, Valentina, Berger, Steven, Kerr, Hu Sheng, Qian, Mark, McHugh, Hongxing, Chen, Xiaomei, Zhang, Miranda L, Carpenter, Heather N, Robinson, John, Miglietta, Thorsten, Lamla, Ryan M, Fryer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:266-276
Diabetic nephropathy is a leading cause of end-stage renal disease, characterized by endothelial dysfunction and a compromised glomerular permeability barrier. Dysregulation of the angiopoietin 1 (ANGPT1)/angiopoietin 2 (ANGPT2) signaling axis is imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374bd8d82a45deba15901277988434a3
https://doi.org/10.1124/jpet.121.001067
https://doi.org/10.1124/jpet.121.001067
Autor:
Eva Griesser, Martin Gesell, Daniel Veyel, Thorsten Lamla, Kerstin Geillinger‐Kästle, Wolfgang Rist
Publikováno v:
PROTEOMICS. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69bbfd4a67b6a8c469faa9f73e1cef05
https://doi.org/10.1002/pmic.202100414
https://doi.org/10.1002/pmic.202100414
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targeting inso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8926442dadbf8f2667aede74b3b6140c
https://doi.org/10.1101/2022.11.30.518485
https://doi.org/10.1101/2022.11.30.518485
Autor:
Stefan Liebau, Udo Maier, Natalia Pashkovskaia, Stefan Kauschke, Peter Loskill, Alexander Kleger, Julia Roosz, Birgit Stierstorfer, Lena Mesch, Johanna Chuchuy, Matthias J. Düchs, Selin Pars, Sebastian Kreuz, Sophia-Marie Hartmann, Kevin Achberger, Virginia Cora, Madalena Cipriano, Stefan Michelfelder, Christian Schön, Thorsten Lamla, Serena Corti
Publikováno v:
Stem Cell Reports
Summary Gene therapies using adeno-associated viruses (AAVs) are among the most promising strategies to treat or even cure hereditary and acquired retinal diseases. However, the development of new efficient AAV vectors is slow and costly, largely bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e1c1e22c62fe5b3bca7a65054cbdb2
https://doi.org/10.1016/j.stemcr.2021.08.008
https://doi.org/10.1016/j.stemcr.2021.08.008
Autor:
Jonas Weinmann, Julia Söllner, Sarah Abele, Gudrun Zimmermann, Kai Zuckschwerdt, Christine Mayer, Jenny Danner-Liskus, Alexander Peltzer, Michael Schuler, Thorsten Lamla, Benjamin Strobel
Publikováno v:
Human gene therapy. 33(21-22)
Adeno-associated viruses (AAVs) represent highly attractive gene therapy vectors and potent research tools for the modulation of gene expression in animal models or difficult-to-transfect cell cultures. Engineered variants, comprising chimeric, mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237456ea82ba71d2e49cab89276c250d
https://pubmed.ncbi.nlm.nih.gov/36097758
https://pubmed.ncbi.nlm.nih.gov/36097758