Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Thorsten, Gnad"'
Autor:
Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring, Alexander Pfeifer, Bernd Nürnberg
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101910- (2024)
Externí odkaz:
https://doaj.org/article/0e781ba108e140ccb990514b92b71624
Autor:
Julia Münzker, Nadine Haase, Andreas Till, Robert Sucher, Sven-Bastiaan Haange, Linda Nemetschke, Thorsten Gnad, Elisabeth Jäger, Jiesi Chen, Sjaak J. Riede, Rima Chakaroun, Lucas Massier, Peter Kovacs, Mario Ost, Ulrike Rolle-Kampczyk, Nico Jehmlich, Juliane Weiner, John T. Heiker, Nora Klöting, Gudrun Seeger, Markus Morawski, Verena Keitel, Alexander Pfeifer, Martin von Bergen, Joerg Heeren, Ute Krügel, Wiebke K. Fenske
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Background Bariatric surgery remains the most effective therapy for adiposity reduction and remission of type 2 diabetes. Although different bariatric procedures associate with pronounced shifts in the gut microbiota, their functional role i
Externí odkaz:
https://doaj.org/article/6a766a44ecdc4c6c87577142da2ab281
Autor:
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Francesca Copperi et al. evaluate the role of the Gi-protein coupled receptor, EBI2, on regulation of thermogenic activity in murine and human adipocytes. They report that loss of Ebi2 in mice increases brown adipocyte energy expenditure in response
Externí odkaz:
https://doaj.org/article/38c7ef6bb2f0416ea97ba86de74291a0
Autor:
Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring, Alexander Pfeifer, Bernd Nürnberg
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101029- (2020)
Objectives: Typically, obesity results from an inappropriate balance between energy uptake from nutrient consumption and burning of calories, which leads to a pathological increase in fat mass. Obesity is a major cause of insulin resistance and diabe
Externí odkaz:
https://doaj.org/article/34f202ff07b54d34853401592e1507ca
Autor:
Anja Glöde, Jennifer Naumann, Thorsten Gnad, Valentina Cannone, Ana Kilic, John C. Burnett, Jr., Alexander Pfeifer
Publikováno v:
Molecular Metabolism, Vol 6, Iss 3, Pp 276-287 (2017)
Objective: Obesity is defined as an abnormal increase in white adipose tissue (WAT) and is a major risk factor for type 2 diabetes and cardiovascular disease. Brown adipose tissue (BAT) dissipates energy and correlates with leanness. Natriuretic pept
Externí odkaz:
https://doaj.org/article/e9f6437375d8496da2c195cb7ad676be
Autor:
Mohammed K Hankir, Mathias Kranz, Thorsten Gnad, Juliane Weiner, Sally Wagner, Winnie Deuther‐Conrad, Felix Bronisch, Karen Steinhoff, Julia Luthardt, Nora Klöting, Swen Hesse, John P Seibyl, Osama Sabri, John T Heiker, Matthias Blüher, Alexander Pfeifer, Peter Brust, Wiebke K Fenske
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 7, Pp 796-812 (2016)
Abstract Phosphodiesterase type 10A (PDE10A) is highly enriched in striatum and is under evaluation as a drug target for several psychiatric/neurodegenerative diseases. Preclinical studies implicate PDE10A in the regulation of energy homeostasis, but
Externí odkaz:
https://doaj.org/article/9dcbc0c76f9f453e9ca5c9c465a135fb
Autor:
Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice
Externí odkaz:
https://doaj.org/article/7a2bc9f5eaee4df68bf0b1b7a219eba3
Autor:
Katharina Sieckmann, Nora Winnerling, Mylene Huebecker, Philipp Leyendecker, Dalila Juliana Silva Ribeiro, Thorsten Gnad, Alexander Pfeifer, Dagmar Wachten, Jan N. Hansen
Publikováno v:
Molecular Biology of the Cell. 33
The different adipose tissues (ATs) can be distinguished according to their function. For example, white AT stores energy in form of lipids, whereas brown AT dissipates energy in the form of heat. These functional differences are represented in the r
Autor:
Sajjad Khani, Hande Topel, Ajeetha Josephrajan, Bjørk Ditlev Marcher Larsen, Ana Rita Albuquerque de Almeida Tavanez, Michael James Gaudry, Philipp Leyendecker, Natasa Stanic, Isabella Gaziano, Nils Rouven Hansmeier, Elena Schmidt, Paul Klemm, Lara-Marie Vagliano, Christoph Andreas Engelhard, Søren Nielsen, Naja Zenius Jespersen, Rizwan Rehimi, Sabrina Gohlke, Peter Frommolt, Thorsten Gnad, Alvaro Rada-Iglesias, Marta Pradas-Juni, Tim Julius Schulz, Frank Thomas Wunderlich, Alexander Pfeifer, Martin Jastroch, Dagmar Wachten, Jan-Wilhelm Kornfeld
Promoting brown adipose tissue (BAT) activity has been recognized as innovative therapeutic approach to improve obesity and metabolic disease. Whilst the molecular circuitry underlying thermogenic activation of BAT is well understood, the processes u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d092b5818b47d49297399104bc4b2dce
https://doi.org/10.1101/2022.08.01.502156
https://doi.org/10.1101/2022.08.01.502156
Autor:
Julia, Münzker, Nadine, Haase, Andreas, Till, Robert, Sucher, Sven-Bastiaan, Haange, Linda, Nemetschke, Thorsten, Gnad, Elisabeth, Jäger, Jiesi, Chen, Sjaak J, Riede, Rima, Chakaroun, Lucas, Massier, Peter, Kovacs, Mario, Ost, Ulrike, Rolle-Kampczyk, Nico, Jehmlich, Juliane, Weiner, John T, Heiker, Nora, Klöting, Gudrun, Seeger, Markus, Morawski, Verena, Keitel, Alexander, Pfeifer, Martin, von Bergen, Joerg, Heeren, Ute, Krügel, Wiebke K, Fenske
Publikováno v:
Microbiome 10:96 (2022)
BACKGROUND: Bariatric surgery remains the most effective therapy for adiposity reduction and remission of type 2 diabetes. Although different bariatric procedures associate with pronounced shifts in the gut microbiota, their functional role in the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d4ae28282c582ff4774958d74b7ac8f7
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65534
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65534