Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thorpe AA"'
Autor:
Ian M. Brook, Chris Sammon, Paula M. Farthing, Jill Callaghan, Christine Freeman, Christine L. Le Maitre, Thorpe Aa, Paul V. Hatton
Publikováno v:
Oncotarget
Bone loss resulting from degenerative diseases and trauma is a significant clinical burden which is likely to grow exponentially with the aging population. In a number of conditions where pre-formed materials are clinically inappropriate an injectabl
Publikováno v:
JOR Spine, Vol 2, Iss 2, Pp n/a-n/a (2019)
JOR Spine
JOR Spine
We have previously reported a synthetic Laponite crosslinked poly N‐isopropylacrylamide‐co‐N, N′‐dimethylacrylamide (NPgel) hydrogel, which induces nucleus pulposus (NP) cell differentiation of human mesenchymal stem cells (hMSCs) without t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9da40e86c8f62d4239ee0590d39109
https://shura.shu.ac.uk/24679/8/LeMaitre-MesenchymalStemCells(VoR).pdf
https://shura.shu.ac.uk/24679/8/LeMaitre-MesenchymalStemCells(VoR).pdf
Publikováno v:
European Cells & Materials, Vol 32, Pp 1-23 (2016)
Bone loss associated with degenerative disease and trauma is a clinical problem increasing with the aging population. Thus, effective bone augmentation strategies are required; however, many have the disadvantages that they require invasive surgery a
Autor:
Chris Sammon, Thorpe Aa
Publikováno v:
Stem Cells Research, Development & Therapy. 2:1-9
Low back pain, strongly associated with intervertebral disc degeneration, is one of the most prevalent health problems in the western world today. Current treatments have been directed toward alleviating patient symptoms but have been shown to accele
Publikováno v:
Thorpe, A A, Dougill, G, Vickers, L, Reeves, ND, Sammon, C, Cooper, G & Le Maitre, C L 2017, ' Thermally Triggered Hydrogel Injection Into Bovine Intervertebral Disc Tissue Explants Induces Differentiation Of Mesenchymal Stem Cells And Restores Mechanical Function ', Acta Biomaterialia, vol. 54, pp. 212-226 . https://doi.org/10.1016/j.actbio.2017.03.010
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical succes
Publikováno v:
Oncotarget, 7(3), 2189. Impact Journals
Oncotarget
Oncotarget
Progress in mesenchymal stem cell (MSC) based therapies for nucleus pulposus (NP) regeneration are hampered by a lack of understanding and consensus of the normal NP cell phenotype. Despite the recent consensus paper on NP markers, there is still a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb434ce67f6fb348102fc6441abaae2
https://dspace.library.uu.nl/handle/1874/345829
https://dspace.library.uu.nl/handle/1874/345829
Publikováno v:
Acta biomaterialia. 36
There is an urgent need for new therapeutic options for low back pain, which target degeneration of the intervertebral disc (IVD). Here, we investigated a pNIPAM hydrogel system, which is liquid at 39°C ex vivo, where following injection into the IV
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Akademický článek
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