Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

Autor: Thornton W Thompson, Benjamin T Jackson, P Jonathan Li, Jiaxi Wang, Alexander Byungsuk Kim, Kristen Ting Hui Huang, Lily Zhang, David H Raulet

Publikováno v: eLife, Vol 7 (2018)

NKG2D is an important immunoreceptor expressed on the surface of NK cells and some T cells. NKG2D recognizes a set of ligands typically expressed on infected or transformed cells, but recent studies have also documented NKG2D ligands on subsets of ho

Externí odkaz: https://doaj.org/article/a0150a9442354866b4ce50e5b63a7e36

NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma

Autor: Isabella Rauch, Thornton W Thompson, Katherine A. Deets, Roberto A. Chavez, Jeannette L. Tenthorey, Russell E. Vance

Publikováno v: The Journal of Experimental Medicine

Clarifying conflicting previous reports, Tenthorey et al. demonstrate, in vitro and in vivo, that phosphorylation of NLRC4 is neither necessary nor sufficient for NAIP/NLRC4 inflammasome activation. Further, NLRC4 plays no role in a model of melanoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809353212fcfe0e4c183cbf5a9b13786
http://europepmc.org/articles/PMC7336302

Immunosurveillance and immunotherapy of tumors by innate immune cells

Autor: David H. Raulet, Assaf Marcus, Thornton W Thompson, Alexandre Iannello, Michele Ardolino

Publikováno v: Current opinion in immunology, vol 38
Iannello, A; Thompson, TW; Ardolino, M; Marcus, A; & Raulet, DH. (2016). Immunosurveillance and immunotherapy of tumors by innate immune cells. Current Opinion in Immunology, 38, 52-58. doi: 10.1016/j.coi.2015.11.001. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9t3505px

© 2015 Elsevier Ltd. Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756137bec04e7a40759deb22634f6a02
https://doi.org/10.1016/j.coi.2015.11.001

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation

Autor: Stuart J. Macdonald, David J. Davido, Steven Haenchen, Lynda A. Morrison, Thornton W. Thompson, Adam J. Konen, Joshua G. Hilliard, Heba H. Mostafa

In the process of generating herpes simplex virus 1 (HSV-1) mutations in the viral regulatory gene encoding infected cell protein 0 (ICP0), we isolated a viral mutant, termed KOS-NA, that was severely impaired for acute replication in the eyes and tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2685679c9583b99eb64371d51f151fa7
https://europepmc.org/articles/PMC5972887/

Author response: Endothelial cells express NKG2D ligands and desensitize antitumor NK responses

Autor: Thornton W Thompson, Alexander Byungsuk Kim, P Jonathan Li, Jiaxi Wang, Benjamin T Jackson, Kristen Ting Hui Huang, Lily Zhang, David H Raulet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f91b938d5725986024e1581789705bfc
https://doi.org/10.7554/elife.30881.021