An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion.

Autor: Thornton, L. Brock¹, Teehan, Paige¹, Floyd, Katherine¹, Cochrane, Christian¹, Bergmann, Amy¹, Riegel, Bryce^2,3, Stasic, Andrew J.^4,5, Di Cristina, Manlio⁶, Moreno, Silvia N. J.^4,5, Roepe, Paul D.^2,3, Dou, Zhicheng¹ zdou@clemson.edu

Publikováno v: PLoS Pathogens. 6/6/2019, Vol. 15 Issue 6, p1-36. 36p.

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A cathepsin C-like protease post-translationally modifies Toxoplasma gondii secretory proteins for optimal invasion and egress.

Autor: Thornton LB; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America., Key M; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America., Micchelli C; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America., Stasic AJ; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.; Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America., Kwain S; Department of Chemistry, Clemson University, Clemson, South Carolina, United States of America., Floyd K; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America., Moreno SNJ; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.; Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America., Dominy BN; Department of Chemistry, Clemson University, Clemson, South Carolina, United States of America., Whitehead DC; Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina, United States of America.; Department of Chemistry, Clemson University, Clemson, South Carolina, United States of America., Dou Z; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.; Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina, United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 22. Date of Electronic Publication: 2023 Jan 22.