Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thornik Reimer"'
Autor:
Jane Connor, Sean Turman, Payal Mehta, Roland Kolbeck, Ling-Ling An, Brian Naiman, Michael Fung, Linda Xu, Miguel A. Sanjuan, Thornik Reimer
Publikováno v:
European Journal of Immunology. 44:3669-3679
Anaphylatoxin C5a released upon complement activation is associated with both acute and chronic inflammations such as gout. The pathogenesis of gout was identified as uric acid crystal deposition in the joints that activates inflammasome, leading to
Autor:
Pranal J. Dakle, F. Anthony Romero, Alexander B. Taylor, Charlie Hatton, Venita G. Watson, Hari Jayaram, Srimoyee Ghosh, Andres Salmeron, Peter Sandy, Steve Bellon, Deanna A. Mele, Jennifer A. Mertz, Thornik Reimer, Hon-Ren Huang, Jose M. Lora, Georgia Hatzivassiliou, Laura Zawadzke, Richard T. Cummings, Robert J. Sims, Jeremy W. Setser, Eneida Pardo, Alexandre Côté, Steven Magnuson, Barbara M. Bryant, James E. Audia, Eugene Chiang, Andrew R. Conery, Florence Poy, Andrea G. Cochran, Melissa Chin, Jean-Christophe Harmange, Vickie Tsui, Brian K. Albrecht, Terry Crawford, Denise DeAlmeida-Nagata, Jane L. Grogan
Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding modules that inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a712c5d807a46e4b8f4f88a0d24e73
https://europepmc.org/articles/PMC4933219/
https://europepmc.org/articles/PMC4933219/
Autor:
Taro Kawai, Yun Gi Kim, Christiane E. Wobus, Darren P. Baker, Himanshu Kumar, Thornik Reimer, Gabriel Núñez, Jong Hwan Park, Shizuo Akira
Publikováno v:
Cell Host & Microbe. 9(6):496-507
SummarySecondary bacterial infection is a common sequela to viral infection and is associated with increased lethality and morbidity. However, the underlying mechanisms remain poorly understood. We show that the TLR3/MDA5 agonist poly I:C or viral in
Autor:
Shizuo Akira, Thornik Reimer, Toshihiro Horii, Michael H. Shaw, Gabriel Núñez, Cevayir Coban, Luigi Franchi, Ana Rodriguez, Ken Ishii
Publikováno v:
European Journal of Immunology. 40:764-769
Cerebral malaria is the most severe complication of Plasmodium falciparum infection in humans and the pathogenesis is still unclear. Using the Plasmodium berghei ANKA infection model of mice, we investigated a potential involvement of Nlrp3 and the i
Autor:
Thornik Reimer, Shizuo Akira, Gabriel Núñez, Ken Ishii, Atsushi Nakagawa, Shohei Koyama, Fumihiko Takeshita, Toshihiro Tsukui, Cevayir Coban, Toshihiro Horii, Masanori Yagi, Kazuo Sakurai, Keiichi Ohata, Taiki Aoshi, Takahisa Ikegami, Yoshikatsu Igari
Publikováno v:
Cell Host & Microbe. 7(1):50-61
SummaryAlthough whole-parasite vaccine strategies for malaria infection have regained attention, their immunological mechanisms of action remain unclear. We find that immunization of mice with a crude blood stage extract of the malaria parasite Plasm
Autor:
Thornik Reimer, M. Fresno, Neil Warner, Guillermo Gabriel Nuñez, Michael H. Shaw, Carmen Sánchez-Valdepeñas, Yun Gi Kim
Publikováno v:
Nature Immunology. 10:1267-1274
Nod2 belongs to the nucleotide-binding oligomerization domain receptor (NLR) family of proteins, which function as intracellular pathogen sensors in innate immune cells. Nod2 deficiency results in an impaired immune response to bacterial pathogens. H
Publikováno v:
Current Opinion in Immunology. 20:377-382
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) (nucleotide-binding domain leucine-rich repeat containing) family of proteins has been demonstrated to function as regulators of innate immune response against microbial pathogen
Publikováno v:
Journal of Interferon & Cytokine Research. 27:751-756
Induction of interferon-beta (IFN-beta) gene expression is a tightly regulated process, and a plethora of studies identified the signal transduction pathway TANK-binding kinase-1 (TBK-1)/IFN regulatory factor-3 (IRF-3) as essential to the induction o
Autor:
Ling-Ling, An, Payal, Mehta, Linda, Xu, Sean, Turman, Thornik, Reimer, Brian, Naiman, Jane, Connor, Miguel, Sanjuan, Roland, Kolbeck, Michael, Fung
Publikováno v:
European journal of immunology. 44(12)
Anaphylatoxin C5a released upon complement activation is associated with both acute and chronic inflammations such as gout. The pathogenesis of gout was identified as uric acid crystal deposition in the joints that activates inflammasome, leading to
Publikováno v:
European journal of immunology. 40(3)
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial an