Infliximab versus alpha interferon in the treatment of Behçet’s disease: the BIO BEHÇET’S RCT

Autor: Robert J Moots, Farida Fortune, Richard Jackson, Tony Thornburn, Ann W Morgan, Dan Carr, Philip Ian Murray, Graham Robert Wallace, Deva Situnayake

Publikováno v: Efficacy and Mechanism Evaluation, Vol 11, Iss 17 (2024)

Background While biologic therapy, typically with infliximab or Roferon, was used for Behçet syndrome after first-line immunosuppressants, no high-quality randomised trials or predictive biomarkers were available. Objective To undertake a randomised

Externí odkaz: https://doaj.org/article/1853582aa52741d898760764179f32f0

Infliximab versus alpha interferon in the treatment of Behçet's disease: the BIO BEHÇET'S RCT.

Autor: Moots, Robert J, Fortune, Farida, Jackson, Richard, Thornburn, Tony, Morgan, Ann W, Carr, Dan, Murray, Philip Ian, Wallace, Graham Robert, Situnayake, Deva

Publikováno v: Efficacy & Mechanism Evaluation (EME); 10/31/2024, Vol. 11 Issue 17/18, p1-77, 77p

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.

Autor: David Mellis, Katherine A Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H Ralston, Donald M Salter, Natalia A Riobo-Del Galdo, Robert E Hill, Mark Ditzel

Publikováno v: PLoS Genetics, Vol 17, Iss 4, p e1009275 (2021)

Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the

Externí odkaz: https://doaj.org/article/7d80a4cd974e4d41902b984699e2a974

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice

Autor: Rachel L. Berry, Derya D. Ozdemir, Bruce Aronow, Nils O. Lindström, Tatiana Dudnakova, Anna Thornburn, Paul Perry, Richard Baldock, Chris Armit, Anagha Joshi, Cécile Jeanpierre, Jingdong Shan, Seppo Vainio, James Baily, David Brownstein, Jamie Davies, Nicholas D. Hastie, Peter Hohenstein

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 8, Pp 903-917 (2015)

Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour supp

Externí odkaz: https://doaj.org/article/91a4163cc6854a4d936c53b9850ade29

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis

Autor: Michela Grillo, Natalia A. Riobo-Del Galdo, Robert E. Hill, Malgorzata Kubiak, David Mellis, Elaine Kinsella, Donald Salter, Ioanna Ch. Georgiou, Katherine Staines, Silvia Peluso, Rob van't Hof, Anna Thornburn, Natalie Dora, Stuart H. Ralston, Colin Farquharson, Mark Ditzel

Publikováno v: PLoS Genetics, Vol 17, Iss 4, p e1009275 (2021)
PLOS GENETICS
Mellis, D, Staines, K, Peluso, S, Georgiou, I C, Dora, N, Kubiak, M, van't Hof, R, Grillo, M, Farquharson, C, Kinsella, E, Thornburn, A, Ralston, S H, Salter, D M, Riobo-Del Galdo, N A, Hill, R E & Ditzel, M 2021, ' Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009275
PLoS Genetics

Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a52668b3bca56103d39e02d6dfc082
https://eprints.whiterose.ac.uk/173526/1/journal.pgen.1009275.pdf