Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thorey K Jonsdottir"'
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those
Externí odkaz:
https://doaj.org/article/255e629500da4e7bab4f1622c9b59485
Autor:
Natalie A Counihan, Scott A Chisholm, Hayley E Bullen, Anubhav Srivastava, Paul R Sanders, Thorey K Jonsdottir, Greta E Weiss, Sreejoyee Ghosh, Brendan S Crabb, Darren J Creek, Paul R Gilson, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium falciparum parasites, the causative agents of malaria, modify their host erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and for removal of toxic waste. Here we investigate the contribution of the rhop
Externí odkaz:
https://doaj.org/article/97ed3bf0078b4d8eba8c42a7a6284862
Autor:
Claudia B. G. Barnes, Madeline G. Dans, Thorey K. Jonsdottir, Brendan S. Crabb, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compo
Externí odkaz:
https://doaj.org/article/08cdd3cfaeed4e469e4110a4b51aef51
Autor:
Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir, David T. Riglar, Oliver Looker, Catherine S. Palmer, Betty Kouskousis, Sarah C. Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo‐Anne Chan, Tania F. de Koning‐Ward, Jake Baum, James W. Kazura, James G. Beeson, Alan F. Cowman, Paul R. Gilson, Brendan S. Crabb
Publikováno v:
Molecular Microbiology. 117:1245-1262
Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e333ce452776bb3cf5ddf9a8f4b7c1
https://doi.org/10.1111/mmi.14904
https://doi.org/10.1111/mmi.14904
Autor:
Thorey K. Jonsdottir, Brendan Elsworth, Simon Cobbold, Mikha Gabriela, Sarah C. Charnaud, Madeline G. Dans, Molly Parkyn Schneider, Malcolm McConville, Hayley E. Bullen, Brendan S. Crabb, Paul R. Gilson
A key element ofPlasmodiumbiology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ff022b7b4d76b6f7b08f5acf98b01d
https://doi.org/10.1101/2022.11.15.516562
https://doi.org/10.1101/2022.11.15.516562
Autor:
Madeline G. Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Sujaan Das, Molly Parkyn Schneider, Thorey K. Jonsdottir, Mikha Gabriela, Maria R. Gancheva, Christopher J. Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I. McFadden, Danny W. Wilson, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Brad E. Sleebs, Inari Kursula, Paul R. Gilson
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell invasion, and have g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce01f8df6990aa8f2e44e034dbc1bac0
https://doi.org/10.1101/2022.09.29.510018
https://doi.org/10.1101/2022.09.29.510018
Autor:
Thorey K Jonsdottir, Brendan S. Crabb, Mikha Gabriela, Tania F. de Koning-Ward, Paul R. Gilson
Publikováno v:
Trends in Parasitology. 37:664-675
To survive inside red blood cells (RBCs), malaria parasites export many proteins to alter their host cell's physiological properties. Although most proteins of this exportome are involved in immune avoidance or in the trafficking of exported proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70acf5bb4dd67c0bb9618656c5439fe
https://doi.org/10.1016/j.pt.2021.04.009
https://doi.org/10.1016/j.pt.2021.04.009
Autor:
Lisa Jones, Stuart A. Ralph, Thorey K Jonsdottir, Coralie Boulet, Lily Tran, Michelle L Power, Siobhon L. Egan, Mae Af White
Publikováno v:
Trends in Parasitology
Recognizing the significant impacts of the coronavirus disease 2019 (COVID-19) pandemic for early-career researchers (ECRs), the Australian Society for Parasitology Inc. organized an online conference ‘Parasitravaganza 2020’ on 30–31 July this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98b11acab71847237dac0b692d548e6
https://doi.org/10.1016/j.pt.2020.09.009
https://doi.org/10.1016/j.pt.2020.09.009
Publikováno v:
Advances in experimental medicine and biology. 1340
The genus Plasmodium comprises intracellular eukaryotic parasites that infect many vertebrate groups and cause deadly malaria disease in humans. The parasites employ a suite of heat shock proteins to help traffic other proteins to different compartme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ddc07eb4267e56d9f2f1cf3fa2ac4c34
https://pubmed.ncbi.nlm.nih.gov/34569024
https://pubmed.ncbi.nlm.nih.gov/34569024