Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Thorbald Van Hall"'
Autor:
Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük, Katy Lloyd, Vitalijs Ovcinnikovs, Gijs G. Zom, Renoud J. Marijnissen, Christianne Groeneveldt, Lisa Griffioen, Gerwin G. W. Sandker, Sandra Heskamp, Sjoerd H. van der Burg, Tsolere Arakelian, Ferry Ossendorp, Ramon Arens, Janine Schuurman, Kristel Kemper, Thorbald van Hall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CD3 bispecific antibody (CD3 bsAb) therapy is clinically approved for refractory hematological malignancies, but responses in solid tumors have been limited so far. One of the main hurdles in solid tumors is the lack of sufficient T-cell inf
Externí odkaz:
https://doaj.org/article/36795cab2cda485e96053669065dc63a
Autor:
Jim Middelburg, Soroush Ghaffari, Tom A.W. Schoufour, Marjolein Sluijter, Gaby Schaap, Büsra Göynük, Benedetta M. Sala, Lejla Al-Tamimi, Ferenc Scheeren, Kees L.M.C. Franken, Jimmy J.L.L. Akkermans, Birol Cabukusta, Simone A. Joosten, Ian Derksen, Jacques Neefjes, Sjoerd H. van der Burg, Adnane Achour, Ruud H.M. Wijdeven, Jon Weidanz, Thorbald van Hall
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113516- (2023)
Summary: The immune checkpoint NKG2A/CD94 is a promising target for cancer immunotherapy, and its ligand major histocompatibility complex E (MHC-E) is frequently upregulated in cancer. NKG2A/CD94-mediated inhibition of lymphocytes depends on the pres
Externí odkaz:
https://doaj.org/article/380d9d0a2508416bb76695633b6aeefe
Autor:
Thorbald van Hall, Jim Middelburg, Gerwin Gerhard Wemke Sandker, Evienne Wilbrink, Janneke Molkenboer-Kuenen, Erik Aarntzen, Sandra Heskamp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background CD3 bispecific antibodies (CD3-bsAbs) require binding of both a tumor-associated surface antigen and CD3 for their immunotherapeutic effect. Their efficacy is, therefore, influenced by the tumor uptake and the extracellular dose. To optimi
Externí odkaz:
https://doaj.org/article/a20cb64dfac3462d8468563a33246239
Autor:
Yixin Luo, Maarten H. Vermeer, Sanne de Haan, Priscilla Kinderman, Frank R. de Gruijl, Thorbald van Hall, Cornelis P. Tensen
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101535- (2023)
Recent detailed genomic analysis of mycosis fungoides (MF) identified suppressor of cytokine signaling 1 (SOCS1), an inhibitor of JAK/STAT signaling, as one of the frequently deleted tumor suppressors in MF, and one-copy deletion of SOCS1 was confirm
Externí odkaz:
https://doaj.org/article/b9355e1eca9f464bb2d0eb5d5e974c60
Autor:
Sjoerd H van der Burg, Thorbald van Hall, Camilla Labrie, Marit J van Elsas, Pornpimol Charoentong, Jordi J C van Stigt Thans, Anders Etzerodt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Primary and secondary resistance is a major hurdle in cancer immunotherapy. Therefore, a better understanding of the underlying mechanisms involved in immunotherapy resistance is of pivotal importance to improve therapy outcome.Method Here
Externí odkaz:
https://doaj.org/article/37f0719b90c040e2aafd9442fcd7cedf
Autor:
Yixin Luo, Maarten H. Vermeer, Frank R. de Gruijl, Willem H. Zoutman, Marjolein Sluijter, Thorbald van Hall, Cornelis P. Tensen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionMycosis fungoides (MF), the most common type of Cutaneous T cell Lymphoma (CTCL), is characterized by an inflamed skin intermixed with proliferating malignant mature skin-homing CD4+ T cells. Detailed genomic analyses of MF skin biopsies
Externí odkaz:
https://doaj.org/article/a9c3b8f9ce1e4ade8c292c714046e8f5
Autor:
Rob C Hoeben, Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Joke M M Den Haan, Camilla Labrie, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Nadine van Montfoort, Lisa Griffioen, Jordi J C van Stigt Thans
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherap
Externí odkaz:
https://doaj.org/article/3366d822d5c7405c92a4c4b02eb41013
Autor:
Peter A van Veelen, Jacques Neefjes, Sjoerd H van der Burg, Thorbald van Hall, Marten Visser, Linda de Bruin, Lukas JAC Hawinkels, James CH Hardwick, Saskia J Santegoets, Tom J Harryvan, Léonie Plug, Lisa Griffioen, Arend Mulder, Gerbrand J van der Heden van Noort, Marlieke LM Jongsma, Miranda H Meeuwsen, Emmanuel JHJ Wiertz, Els ME Verdegaal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associat
Externí odkaz:
https://doaj.org/article/445d6f47a6724dfba4c033a139d8a46b
Autor:
Somayeh Rostamian, Saskia le Cessie, Koen A Marijt, J Wouter Jukema, Simon P Mooijaart, Mark A van Buchem, Thorbald van Hall, Jacobijn Gussekloo, Stella Trompet
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261826 (2022)
BackgroundDisturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of
Externí odkaz:
https://doaj.org/article/190d6e363d6549ee8f85a67f5abd674b
Autor:
Thorbald van Hall, Pascale André, Amir Horowitz, Dan Fu Ruan, Linda Borst, Robert Zerbib, Emilie Narni-Mancinelli, Sjoerd H. van der Burg, Eric Vivier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract The implementation of immune checkpoint inhibitors to the oncology clinic signified a new era in cancer treatment. After the first indication of melanoma, an increasing list of additional cancer types are now treated with immune system targe
Externí odkaz:
https://doaj.org/article/33a6e9155eae490899e9e33fa89fc794