Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.

Autor: Julia Bender, Maik Engeholm, Marion S Ederer, Johannes Breu, Thor C Møller, Stylianos Michalakis, Tamas Rasko, Erich E Wanker, Martin Biel, Karen L Martinez, Wolfgang Wurst, Jan M Deussing

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0136768 (2015)

The corticotropin-releasing hormone receptor type 1 (CRHR1) plays an important role in orchestrating neuroendocrine, behavioral, and autonomic responses to stress. To identify molecules capable of directly modulating CRHR1 signaling, we performed a y

Externí odkaz: https://doaj.org/article/9d49b92304a34288ad9452b996ef64a7

Identification of a novel protein-protein interaction motif mediating interaction of GPCR-associated sorting proteins with G protein-coupled receptors.

Autor: Olivier Bornert, Thor C Møller, Julien Boeuf, Marie-Pierre Candusso, Renaud Wagner, Karen L Martinez, Frederic Simonin

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56336 (2013)

GPCR desensitization and down-regulation are considered key molecular events underlying the development of tolerance in vivo. Among the many regulatory proteins that are involved in these complex processes, GASP-1 have been shown to participate to th

Externí odkaz: https://doaj.org/article/80786f0b2ba24a03ad678b2d0d34b153

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

Autor: Sine P. Schiellerup, Gertrud Malene Hjortø, Mette M. Rosenkilde, Florent Xavier Smit, Olav Larsen, Bolette Hartmann, Thor C. Møller, C. Christiansen, Jens J. Holst, Wijnand J.C. van der Velden, Hans Bräuner-Osborne, Thomas M. Frimurer

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] Biased ligands that selectively confer activity in one pathway over another are pharmacologically important because biased signaling may reduce on-target side effects and improve drug efficacy. Here, we describe an N-terminal modifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1b2b60a588622bae14728766e1f217
https://doi.org/10.1021/acsptsci.0c00193

Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu

Autor: Jeffrey R, van Senten, Thor C, Møller, Ee Von, Moo, Sofie D, Seiersen, Hans, Bräuner-Osborne

Publikováno v: The Journal of biological chemistry. 298(10)

The internalization of G protein-coupled receptors (GPCRs) can be regulated by PKC. However, most tools available to study the contribution of PKC isozymes have considerable limitations, including a lack of selectivity. In this study, we generated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37c6fabe3005ac52426425b58f23519a
https://pubmed.ncbi.nlm.nih.gov/36087841

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

Autor: Paulina Chałupnik, Alina Vialko, Darryl S. Pickering, Markus Hinkkanen, Stephanie Donbosco, Thor C. Møller, Anders A. Jensen, Birgitte Nielsen, Yasmin Bay, Anders S. Kristensen, Tommy N. Johansen, Kamil Łątka, Marek Bajda, Ewa Szymańska

Publikováno v: Chałupnik, P, Vialko, A, Pickering, D S, Hinkkanen, M, Donbosco, S, Møller, T C, Jensen, A A, Nielsen, B, Bay, Y, Kristensen, A S, Johansen, T N, Łątka, K, Bajda, M & Szymańska, E 2022, ' Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype ', International Journal of Molecular Sciences, vol. 23, no. 15, 8797 . https://doi.org/10.3390/ijms23158797
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8797

Kainate receptors belong to the family of glutamate receptors ion channels, which are responsible for the majority of rapid excitatory synaptic transmission in the central nervous system. The therapeutic potential of kainate receptors is still poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0c4d39338c6b94fd44885c211955e3
https://curis.ku.dk/portal/da/publications/discovery-of-the-first-highly-selective-antagonist-of-the-gluk3-kainate-receptor-subtype(1dd1c2f0-5aea-4a68-b87c-cdb85b250a93).html