Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Thompson N Doman"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210910 (2019)
The massive genomic data from The Cancer Genome Atlas (TCGA), including proteomics data from Clinical Proteomic Tumor Analysis Consortium (CPTAC), provides a unique opportunity to study cancer systematically. While most observations are made from a s
Externí odkaz:
https://doaj.org/article/69162dd73db545e697ba470d67e6f49d
Autor:
Ying Chen, Jeremy McGee, Xianming Chen, Thompson N Doman, Xueqian Gong, Youyan Zhang, Nicole Hamm, Xiwen Ma, Richard E Higgs, Shripad V Bhagwat, Sean Buchanan, Sheng-Bin Peng, Kirk A Staschke, Vipin Yadav, Yong Yue, Hosein Kouros-Mehr
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98293 (2014)
The Cancer Genome Atlas (TCGA) projects have advanced our understanding of the driver mutations, genetic backgrounds, and key pathways activated across cancer types. Analysis of TCGA datasets have mostly focused on somatic mutations and translocation
Externí odkaz:
https://doaj.org/article/a29e5a4806f34d02a21d59875c6c8e59
Autor:
Veerabahu Shanmugasundaram, Jürgen Bajorath, Ralph E. Christoffersen, James D. Petke, W. Jeffrey Howe, Mark A. Johnson, Dimitris K. Agrafiotis, Pil Lee, Leslie A. Kuhn, Jay T. Goodwin, M. Katharine Holloway, Thompson N. Doman, W. Patrick Walters, Suzanne Schreyer, José L. Medina-Franco, Karina Martinez-Mayorga, Linda L. Restifo
Publikováno v:
Journal of Computer-Aided Molecular Design. 36:623-638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4fcd4233176dd82476c1a8cc7e31cb1
https://doi.org/10.1007/s10822-022-00473-2
https://doi.org/10.1007/s10822-022-00473-2
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Supplementary Figure Legends & Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057a178b991babc2517ecf5b994d7838
https://doi.org/10.1158/1078-0432.22471418.v1
https://doi.org/10.1158/1078-0432.22471418.v1
Autor:
Heather L. McArthur, Phillip Wong, Danni Yu, Courtney M. Tate, Sonya C. Chapman, Rachel Sanford, Dana E. Rathkopf, Ruslan Novosiadly, Michael J. Morris, Shanu Modi, Philomena F. McAndrew, Jonathan Landa, Praneet Kang, Suhyun Kang, David M. Hoffman, Jill S. Gluskin, Josef J. Fox, Jeremy C. Durack, Thompson N. Doman, Daniel C. Danila, Elizabeth Comen, Michelle Carlsen, Manisha Brahmachary, Victoria S. Blinder, Matthew Adamow, Susan F. Slovin, John Sae Wook Kauh, David Schaer, Christopher A. Klebanoff, Karen A. Autio
Dose selection details, T cell activation/exhaustion flow assay and multiplex cytokine measurements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6a1647f043bba8200217af92661bf3
https://doi.org/10.1158/1078-0432.22477116
https://doi.org/10.1158/1078-0432.22477116
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Figure S1. Efficacy of pemetrexed in Lewis Lung carcinoma model and metabolomic analysis of MC38 tumor bearing mice treated with 50 mg/kg of pemetrexed Figure S2. T cell inflamed phenotype induced by pemetrexed is modestly reduced in tumors upon comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf5c80af2bf8dacf087ab7a6132752
https://doi.org/10.1158/1078-0432.22471421
https://doi.org/10.1158/1078-0432.22471421
Autor:
Heather L. McArthur, Phillip Wong, Danni Yu, Courtney M. Tate, Sonya C. Chapman, Rachel Sanford, Dana E. Rathkopf, Ruslan Novosiadly, Michael J. Morris, Shanu Modi, Philomena F. McAndrew, Jonathan Landa, Praneet Kang, Suhyun Kang, David M. Hoffman, Jill S. Gluskin, Josef J. Fox, Jeremy C. Durack, Thompson N. Doman, Daniel C. Danila, Elizabeth Comen, Michelle Carlsen, Manisha Brahmachary, Victoria S. Blinder, Matthew Adamow, Susan F. Slovin, John Sae Wook Kauh, David Schaer, Christopher A. Klebanoff, Karen A. Autio
Best overall response by RECIST 1.1 and PCWG2 for bone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ea50d2dbcc4f4ef741fbef84f54ba7
https://doi.org/10.1158/1078-0432.22477113.v1
https://doi.org/10.1158/1078-0432.22477113.v1
Autor:
Heather L. McArthur, Phillip Wong, Danni Yu, Courtney M. Tate, Sonya C. Chapman, Rachel Sanford, Dana E. Rathkopf, Ruslan Novosiadly, Michael J. Morris, Shanu Modi, Philomena F. McAndrew, Jonathan Landa, Praneet Kang, Suhyun Kang, David M. Hoffman, Jill S. Gluskin, Josef J. Fox, Jeremy C. Durack, Thompson N. Doman, Daniel C. Danila, Elizabeth Comen, Michelle Carlsen, Manisha Brahmachary, Victoria S. Blinder, Matthew Adamow, Susan F. Slovin, John Sae Wook Kauh, David Schaer, Christopher A. Klebanoff, Karen A. Autio
Purpose:Tumor-associated macrophages correlate with increased invasiveness, growth, and immunosuppression. Activation of the colony-stimulating factor-1 receptor (CSF-1R) results in proliferation, differentiation, and migration of monocytes/macrophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bae612c401ddd59fda360e4f5622f8d
https://doi.org/10.1158/1078-0432.c.6529578.v1
https://doi.org/10.1158/1078-0432.c.6529578.v1
Autor:
Heather L. McArthur, Phillip Wong, Danni Yu, Courtney M. Tate, Sonya C. Chapman, Rachel Sanford, Dana E. Rathkopf, Ruslan Novosiadly, Michael J. Morris, Shanu Modi, Philomena F. McAndrew, Jonathan Landa, Praneet Kang, Suhyun Kang, David M. Hoffman, Jill S. Gluskin, Josef J. Fox, Jeremy C. Durack, Thompson N. Doman, Daniel C. Danila, Elizabeth Comen, Michelle Carlsen, Manisha Brahmachary, Victoria S. Blinder, Matthew Adamow, Susan F. Slovin, John Sae Wook Kauh, David Schaer, Christopher A. Klebanoff, Karen A. Autio
Assessment of tumor associated macrophage depletion using macrophage gene signature. The downward trend (pre vs post, indicating depletion of TAMs) of the gene signature did not appear pronounced in any of the patient samples except for patient C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2377befc9a584f854277bd448efeba9a
https://doi.org/10.1158/1078-0432.22477119.v1
https://doi.org/10.1158/1078-0432.22477119.v1
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Purpose:Combination strategies leveraging chemotherapeutic agents and immunotherapy have held the promise as a method to improve benefit for patients with cancer. However, most chemotherapies have detrimental effects on immune homeostasis and differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55d83fcda2c247c186c9439427cc003
https://doi.org/10.1158/1078-0432.c.6527882.v1
https://doi.org/10.1158/1078-0432.c.6527882.v1