An Electrosynthesis of 1,3,4-Oxadiazoles from N-Acyl Hydrazones.

Autor: Chen L; Medicinal Chemistry, GSK, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.; Pure & Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, United Kingdom., Thompson JDF; Medicinal Chemistry, GSK, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom., Jamieson C; Pure & Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, United Kingdom.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Sep 18, pp. e202403128. Date of Electronic Publication: 2024 Sep 18.

Profile of a Highly Selective Quaternized Pyrrolidine Betaine α v β 6 Integrin Inhibitor-(3 S )-3-(3-(3,5-Dimethyl-1 H -pyrazol-1-yl)phenyl)-4-((1 S and 1 R ,3 R )-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.

Autor: Barrett TN; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Taylor JA; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Barker D; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Procopiou PA; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Thompson JDF; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.; Department of Pure & Applied Chemistry , University of Strathclyde , 295 Cathedral Street , Glasgow , G1 1XL , U.K., Barrett J; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Le J; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Lynn SM; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Pogany P; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Pratley C; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Pritchard JM; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Roper JA; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Rowedder JE; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Slack RJ; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Vitulli G; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Macdonald SJF; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom., Kerr WJ; Department of Pure & Applied Chemistry , University of Strathclyde , 295 Cathedral Street , Glasgow , G1 1XL , U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Aug 22; Vol. 62 (16), pp. 7543-7556. Date of Electronic Publication: 2019 Aug 05.