Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Thompson Gray A"'
Autor:
Ryan P. Ceddia, Zack Zurawski, Analisa Thompson Gray, Feyisayo Adegboye, Ainsley McDonald-Boyer, Fubiao Shi, Dianxin Liu, Jose Maldonado, Jiesi Feng, Yulong Li, Simon Alford, Julio E. Ayala, Owen P. McGuinness, Sheila Collins, Heidi E. Hamm
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Negative regulation of exocytosis from secretory cells is accomplished through inhibitory signals from Gi/o GPCRs by Gβγ subunit inhibition of 2 mechanisms: decreased calcium entry and direct interaction of Gβγ with soluble N-ethylmaleimide–sen
Externí odkaz:
https://doaj.org/article/a5ee21a0d0b84d4e9b842e9bacb8ba19
Autor:
Jayakodiarachchi, Navoda, Maurer, Mallory A., Schultz, Daniel C., Dodd, Cayden J., Thompson Gray, Analisa, Cho, Hyekyung P., Boutaud, Olivier, Jones, Carrie K., Lindsley, Craig W., Bender, Aaron M.
Publikováno v:
ACS Medicinal Chemistry Letters; 2/8/2024, Vol. 15 Issue 2, p302-309, 8p
Autor:
Thompson Gray, Analisa D.1 (AUTHOR), Simonetti, Justice1 (AUTHOR), Adegboye, Feyisayo1 (AUTHOR), Jones, Carrie K.1,2 (AUTHOR), Zurawski, Zack1,3 (AUTHOR), Hamm, Heidi E.1 (AUTHOR) heidi.hamm@vanderbilt.edu
Publikováno v:
European Journal of Neuroscience. Jul2020, Vol. 52 Issue 1, p2815-2826. 12p. 1 Chart, 4 Graphs.
Autor:
Julie L. Engers, Alice L. Rodriguez, Analisa D. Thompson Gray, Corey R. Hopkins, Darren W. Engers, Anna L. Blobaum, Sean R. Bollinger, P. Jeffrey Conn, Colleen M. Niswender, Mary West, Carrie K. Jones, Joseph D. Panarese, Craig W. Lindsley, Matthew T. Loch
Publikováno v:
Journal of Medicinal Chemistry. 62:342-358
This work describes the discovery and characterization of novel 6-(1H-pyrazolo[4,3-b]pyridin-3-yl)amino-benzo[d]isothiazole-3-carboxamides as mGlu4 PAMs. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f31766602e34b5d54fdc293d180b2a
https://doi.org/10.1021/acs.jmedchem.8b00994
https://doi.org/10.1021/acs.jmedchem.8b00994
Autor:
Michael R. Dohn, Brian Page, Nicholas A. Harris, Emily C. Church, Yun Young Yim, Zack Zurawski, Douglas P. Mortlock, Heidi E. Hamm, Karren Hyde, Lillian J. Brady, Carrie K. Jones, A. D. Thompson Gray, Simon Alford, Danny G. Winder
Gi/o-coupled G-protein coupled receptors modulate neurotransmission presynaptically through inhibition of exocytosis. Release of Gβγ subunits decreases the activity of voltage-gated calcium channels (VGCC), decreasing excitability. A less understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3fe4208724978a65e5b284e08b5c50
Autor:
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Bollinger, Katrina A., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Thompson Gray, Analisa, Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 November 2017 27(21):4858-4866
Autor:
Andrew S. Felts, Daryl F. Venable, Frank W. Byers, Analisa D. Thompson Gray, P. Jeffrey Conn, Carrie K. Jones, Brittney S. Bates, Mohammed N. Tantawy, Jerri M. Rook, Craig W. Lindsley, Colleen M. Niswender, Kyle A. Emmitte, Gilles Tamagnan, Vincent B. Luscombe, Anna L. Blobaum, J. Scott Daniels, Alice L. Rodriguez, Sichen Chang, Ryan D. Morrison
Publikováno v:
Journal of Medicinal Chemistry
Preclinical evidence in support of the potential utility of mGlu5 NAMs for the treatment of a variety of psychiatric and neurodegenerative disorders is extensive, and multiple such molecules have entered clinical trials. Despite some promising result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9bf4ee93e41f4306aff0746cd2d2f7
https://pubmed.ncbi.nlm.nih.gov/28530802
https://pubmed.ncbi.nlm.nih.gov/28530802
Autor:
P. Jeffrey Conn, Colleen M. Niswender, Michael Bubser, J. Scott Daniels, Darren W. Engers, Analisa D. Thompson Gray, Matthew T. Loch, Xin Lin, Craig W. Lindsley, Anna L. Blobaum, Alice L. Rodriguez, Carrie K. Jones, Corey R. Hopkins, Jonathan A. Javitch
Publikováno v:
ACS chemical neuroscience. 7(9)
Metabotropic glutamate receptor 4 (mGlu4) is emerging as a potential therapeutic target for numerous central nervous system indications, including Parkinson’s disease (PD). As the glutamate binding sites among the eight mGlu receptors are highly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5cfc31bd8d1468659e68044bc3a5c8
https://pubmed.ncbi.nlm.nih.gov/27441572
https://pubmed.ncbi.nlm.nih.gov/27441572
Autor:
Bollinger, Sean R., Engers, Darren W., Panarese, Joseph D., West, Mary, Engers, Julie L., Loch, Matthew T., Rodriguez, Alice L., Blobaum, Anna L., Jones, Carrie K., Thompson Gray, Analisa, Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.
Publikováno v:
Journal of Medicinal Chemistry; January 2019, Vol. 62 Issue: 1 p342-358, 17p
Autor:
THOMPSON, GRAY
Publikováno v:
TransWorld Snowboarding; Oct2016, Vol. 30 Issue 2, p66-73, 8p, 15 Color Photographs