Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Thommas M. Musyoka"'
Autor:
Fidele Ntie-Kang, Kiran K. Telukunta, Serge A. T. Fobofou, Victor Chukwudi Osamor, Samuel A. Egieyeh, Marilia Valli, Yannick Djoumbou-Feunang, Maria Sorokina, Conrad Stork, Neann Mathai, Paul Zierep, Ana L. Chávez-Hernández, Miquel Duran-Frigola, Smith B. Babiaka, Romuald Tematio Fouedjou, Donatus B. Eni, Simeon Akame, Augustine B. Arreyetta-Bawak, Oyere T. Ebob, Jonathan A. Metuge, Boris D. Bekono, Mustafa A. Isa, Raphael Onuku, Daniel M. Shadrack, Thommas M. Musyoka, Vaishali M. Patil, Justin J. J. van der Hooft, Vanderlan da Silva Bolzani, José L. Medina-Franco, Johannes Kirchmair, Tilmann Weber, Özlem Tastan Bishop, Marnix H. Medema, Ludger A. Wessjohann, Jutta Ludwig-Müller
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract We report the major conclusions of the online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and industry and about 20
Externí odkaz:
https://doaj.org/article/dc580d833d694863bc03b9de2b1575e5
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background South African Natural Compounds Database (SANCDB; https://sancdb.rubi.ru.ac.za/ ) is the sole and a fully referenced database of natural chemical compounds of South African biodiversity. It is freely available, and since its incep
Externí odkaz:
https://doaj.org/article/8a4131ab35e249a4ae8600f9ff19ccc1
Autor:
Silas Onyango Awuor, Eric O. Omwenga, Richard M. Mariita, Jonathan M. Musila, Alexander Mbeke, Thommas M. Musyoka
Diarrhoea diseases are the second leading cause of death among under five children. The situation being worsened by emergence of multi-drug resistant enteric bacteria which are becoming a major global medical and public health problem. This study aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b62d5c71788d8b0405d652a8c390a86
https://doi.org/10.1099/acmi.0.000614.v1
https://doi.org/10.1099/acmi.0.000614.v1
Autor:
Chiamaka Jessica Okeke, Thommas M. Musyoka, Özlem Tastan Bishop, Olivier Sheik Amamuddy, Victor Barozi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5647-5666 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • MD-TASK and MDM-TASK-web tools were applied for mutation analysis. • Cryptic allosteric pocket observed in the presence of M245IPocket 2 became highly rigid in the presence of A353T mutation. • Allosteric co
Highlights • MD-TASK and MDM-TASK-web tools were applied for mutation analysis. • Cryptic allosteric pocket observed in the presence of M245IPocket 2 became highly rigid in the presence of A353T mutation. • Allosteric co
Autor:
Sophakama Zabo, Thommas M. Musyoka, Özlem Tastan Bishop, Rita Afriyie Boateng, Olivier Sheik Amamuddy
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1103-1120 (2020)
Pyrazinamide (PZA) is the only first-line antitubercular drug active against latent Mycobacterium tuberculosis (Mtb). It is activated to pyrazinoic acid by the pncA-encoded pyrazinamidase enzyme (PZase). Despite the emergence of PZA drug resistance,
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134273 (2015)
Complex computational pipelines are becoming a staple of modern scientific research. Often these pipelines are resource intensive and require days of computing time. In such cases, it makes sense to run them over high performance computing (HPC) clus
Externí odkaz:
https://doaj.org/article/b3652df953e54872af29ee8353890864
Autor:
Özlem Tastan Bishop, Bakary N'tji Diallo, Kevin A. Lobb, Michael Glenister, Thommas M. Musyoka
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-14 (2021)
Journal of Cheminformatics
Journal of Cheminformatics
Background South African Natural Compounds Database (SANCDB; https://sancdb.rubi.ru.ac.za/) is the sole and a fully referenced database of natural chemical compounds of South African biodiversity. It is freely available, and since its inception in 20
Autor:
Maureen Bilinga Tendwa, Kevin A. Lobb, Özlem Tastan Bishop, Lorna Chebon-Bore, Thommas M. Musyoka
Publikováno v:
Molecules, Vol 26, Iss 2929, p 2929 (2021)
Molecules
Volume 26
Issue 10
Molecules
Volume 26
Issue 10
The dimeric dihydropyrimidine dehydrogenase (DPD) metalloenzyme, an adjunct anti-cancer drug target contains highly specialized 4 × Fe2+4S2-4 clusters per chain. These clusters facilitate the catalysis of the rate-limiting step in the pyrimidine deg
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-21 (2019)
Malaria Journal
Malaria Journal
Background Falcipains are major cysteine proteases of Plasmodium falciparum involved in haemoglobin degradation and remain attractive anti-malarial drug targets. Several inhibitors against these proteases have been identified, yet none of them has be
Autor:
Vuyani Moses, Xavier Siwe-Noundou, Derek Tantoh Ndinteh, Rui W. M. Krause, Özlem Tastan Bishop, Dumisani Mnkandhla, Thommas M. Musyoka, Heinrich C. Hoppe
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
According to the 2018 report of the United Nations Programme on HIV/AIDS (UNAIDS), acquired immune deficiency syndrome (AIDS), a disease caused by the human immunodeficiency virus (HIV), remains a significant public health problem. The non-existence