Výsledky vyhledávání - "Thome, Ulrich H."

Akademický článek

The Value of Perinatal Factors, Blood Biomarkers and Microbiological Colonization Screening in Predicting Neonatal Sepsis

Autor: Cao, Isabel, Lippmann, Norman, Thome, Ulrich H.

Background: Neonatal sepsis is one of the most important causes of elevated morbidity and mortality rates in neonatal intensive care units worldwide. While the clinical manifestations of neonatal sepsis tend to be nonspecific, its rapid development a

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Akademický článek

Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells

Autor: Naumann, Jonas, Koppe, Nicklas, Thome, Ulrich H., Laube, Mandy, Zink, Mareike

Many preterm infants require mechanical ventilation as life-saving therapy. However, ventilation-induced overpressure can result in lung diseases. Considering the lung as a viscoelastic material, positive pressure inside the lung results in increased

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Akademický článek

Y It Matters: Sex Differences in Fetal Lung Development

Autor: Laube, Mandy, Thome, Ulrich H.

Within this review, sex-specific differences in alveolar epithelial functions are discussed with special focus on preterm infants and the respiratory disorders associated with premature birth. First, a short overview about fetal lung development, the

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Akademický článek

Development and Functional Characterization of Fetal Lung Organoids

Autor: Laube, Mandy, Pietsch, Soeren, Pannicke, Thomas, Thome, Ulrich H., Fabian, Claire

Preterminfants frequently suffer frompulmonary complications due to a physiological and structural lung immaturity resulting in significant morbidity and mortality. Novel in vitro and in vivo models are required to study the underlying mechanisms of

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Akademický článek

Glucocorticoids Equally Stimulate Epithelial Na+ Transport in Male and Female Fetal Alveolar Cells

Autor: Laube, Mandy, Riedel, Diana, Ackermann, Benjamin, Haase, Melanie, Thome, Ulrich H.

Preterm infants frequently suffer from respiratory distress syndrome (RDS), possibly due to lower expression of epithelial Na+ channels (ENaC). RDS incidence is sex-specific, affecting males almost twice as often. Despite the use of antenatal glucoco

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Akademický článek

Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone

Autor: Bossmann, Miriam, Ackermann, Benjamin W., Thome, Ulrich H., Laube, Mandy

Impairment of mucociliary clearance with reduced airway fluid secretion leads to chronically inflamed airways. Cystic fibrosis transmembrane conductance regulator (CFTR) is crucially involved in airway fluid secretion and dexamethasone (dexa) has pre

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Akademický článek

Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition into extrauterine life: Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition intoextrauterine life

Autor: Laube, Mandy, Bossmann, Miriam, Thome, Ulrich H.

Publikováno v: PLoS one 2015, 10 (4): e0124833

During fetal development, the lung is filled with fluid that is secreted by an active Cltransport promoting lung growth. The basolateral Na+,K+,2Cl- cotransporter (NKCC1) participates in Cl- secretion. The apical Cl- channels responsible for secretio

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A13318
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Akademický článek

Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition into extrauterine life

Autor: Laube, Mandy, Bossmann, Miriam, Thome, Ulrich H.

Publikováno v: PLoS one 2015, 10 (4): e0124833

Externí odkaz: http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-169679
http://www.qucosa.de/fileadmin/data/qucosa/documents/16967/OAP-2015-046-Laube.pone.0124833.pdf

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Akademický článek

Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells: Rapid elevation of sodium transport through insulin ismediated by AKT in alveolar cells

Autor: Mattes, Charlott, Thome, Ulrich H.

Publikováno v: Physiological Reports, 2 (3), 20 February 2014 doi: 10.1002/phy2.269

Alveolar fluid clearance is driven by vectorial Na+ transport and promotes postnatal lung adaptation. The effect of insulin on alveolar epithelial Na+ transport was studied in isolated alveolar cells from 18–19-day gestational age rat fetuses. Equi

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Akademický článek

Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells

Autor: Mattes, Charlott, Thome, Ulrich H.

Publikováno v: Physiological Reports, 2 (3), 20 February 2014 doi: 10.1002/phy2.269

Externí odkaz: http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-142643
http://www.qucosa.de/fileadmin/data/qucosa/documents/14264/phy2269.pdf

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