Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions

Autor: Kelly Boelaars, Ernesto Rodriguez, Zowi R. Huinen, Chang Liu, Di Wang, Babet O. Springer, Katarzyna Olesek, Laura Goossens-Kruijssen, Thomas van Ee, Dimitri Lindijer, Willemijn Tak, Aram de Haas, Laetitia Wehry, Joline P. Nugteren-Boogaard, Aleksandra Mikula, Charlotte M. de Winde, Reina E. Mebius, David A. Tuveson, Elisa Giovannetti, Maarten F. Bijlsma, Manfred Wuhrer, Sandra J. van Vliet, Yvette van Kooyk

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts (CAFs)

Externí odkaz: https://doaj.org/article/89d397e7c86647f4a8efdf005a8b83cc

Homologous recombination repair deficient prostate cancer represents an immunologically distinct subtype

Autor: Sandra van Wilpe, Donjetë Simnica, Peter Slootbeek, Thomas van Ee, Samhita Pamidimarri Naga, Mark A. J. Gorris, Lieke L. van der Woude, Shabaz Sultan, Rutger H. T. Koornstra, Inge M. van Oort, Winald R. Gerritsen, Leonie I. Kroeze, Michiel Simons, Geert J. L. H. van Leenders, Mascha Binder, I. Jolanda M. de Vries, Niven Mehra

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Homologous recombination repair deficiency (HRD) is observed in 10% of patients with castrate-resistant prostate cancer (PCa). Preliminary data suggest that HRD-PCa might be more responsive to immune checkpoint inhibitors (ICIs). In this study, we co

Externí odkaz: https://doaj.org/article/abdf79f8e7f4443f9c8ac5c4111ac941

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Autor: R. J. Eveline Li, Nicole C.T. van Grieken, Sjoerd T.T. Schetters, Thomas van Ee, Sven C. M. Bruijns, Kelly Boelaars, Ernesto Rodríguez, Matheus H.W. Crommentuijn, Laura J.W. Kruijssen, Elisa Giovannetti, Joost C. van der Horst, Kari Brown, Sandra J. van Vliet, Geert Kazemier, Juan J. Garcia-Vallejo, Yvette van Kooyk

Publikováno v: Rodriguez, E, Boelaars, K, Brown, K, Eveline Li, R J, Kruijssen, L, Bruijns, S C M, van Ee, T, Schetters, S T T, Crommentuijn, M H W, van der Horst, J C, van Grieken, N C T, van Vliet, S J, Kazemier, G, Giovannetti, E, Garcia-Vallejo, J J & van Kooyk, Y 2021, ' Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9 ', Nature Communications, vol. 12, no. 1, 1270 . https://doi.org/10.1038/s41467-021-21550-4
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12(1):1270. Nature Publishing Group

Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via binding to Siglec receptors. We here show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a9d6c2a58db5a149a8cd1253b52843
https://doi.org/10.1038/s41467-021-21550-4