Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Thomas Y Ma"'
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249544 (2021)
BackgroundMatrix Metalloproteinase-9 (MMP-9) has been shown to play a key role in mediating inflammation and tissue damage in inflammatory bowel disease (IBD). In patients with IBD, the intestinal tight junction (TJ) barrier is compromised as charact
Externí odkaz:
https://doaj.org/article/a99bf2b54bf045f58f910341a4a306e5
Autor:
Mohammad Haque, Lauren Kaminsky, Raz Abdulqadir, Jessica Engers, Evgeny Kovtunov, Manmeet Rawat, Rana Al-Sadi, Thomas Y. Ma
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundDefective intestinal epithelial tight junction (TJ), characterized by an increase in intestinal TJ permeability, has been shown to play a critical role in the pathogenesis of inflammatory bowel disease (IBD). Tumor necrosis factor-α (TNF-
Externí odkaz:
https://doaj.org/article/3d6dadc85d734c34991bd87666b04db4
Autor:
Meghali P Nighot, Prashant K Nighot, Thomas Y Ma, Danuta H Malinowska, Gary E Shull, John Cuppoletti, Anthony T Blikslager
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138174 (2015)
The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, parietal cell abundance, H/K ATPase expression, parietal cell ultrastructure and acid secretion using WT and ClC-2-/- mouse stomachs. Cellular histolog
Externí odkaz:
https://doaj.org/article/177186bc2cbb4f79acdc6d88009881ef
Autor:
Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y Ma
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e85345 (2014)
Defective intestinal epithelial tight junction (TJ) barrier has been shown to be a pathogenic factor in the development of intestinal inflammation. Interleukin-6 (IL-6) is a pleiotropic, pro-inflammatory cytokine which plays an important role in prom
Externí odkaz:
https://doaj.org/article/9450d683aaad49ce99772a26468e984f
Autor:
Irina V Pinchuk, Katherine T Morris, Robert A Nofchissey, Rachel B Earley, Jeng-Yih Wu, Thomas Y Ma, Ellen J Beswick
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53798 (2013)
Gastric cancer is associated with chronic inflammation and Helicobacter pylori infection. Th17 cells are CD4(+) T cells associated with infections and inflammation; but their role and mechanism of induction during carcinogenesis is not understood. Ga
Externí odkaz:
https://doaj.org/article/8fb7fe240d704afea896c6d11c0eba07
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/46f21757596147fda608b89a537d191a
Autor:
Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Thomas Y. Ma, Mohammad Rashedul Haque, Prashant Nighot
Publikováno v:
Am J Pathol
Defective intestinal tight junction (TJ) barrier is an important pathogenic factor of inflammatory bowel disease. To date, no effective therapies that specifically target the intestinal TJ barrier are available. The purpose of this study was to ident
Autor:
Thomas Y. Ma, Prashant Nighot
Publikováno v:
Inflamm Bowel Dis
Eukaryotic cells take up macromolecules and particles from the surrounding milieu and also internalize membrane proteins via a precise process of endocytosis. The role of endocytosis in diverse physiological processes such as cell adhesion, cell sign
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. A defective intestinal TJ barrier has been implicated as an importan
Autor:
Rana Al-Sadi, Prashant Nighot, Thomas Y. Ma, Meghali Nighot, Viszwapriya Dharmaprakash, Toan Do, Shuhong Guo
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8070, p 8070 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences
Volume 22
Issue 15
Defective intestinal tight junction (TJ) barrier is a hallmark in the pathogenesis of inflammatory bowel disease (IBD). To date, there are no effective therapies that specifically target the intestinal TJ barrier. Among the various probiotic bacteria