Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas Wossning"'
Autor:
Arantxa Pérez‐García, Pablo Pérez‐Durán, Thomas Wossning, Isora V Sernandez, Sonia M Mur, Marta Cañamero, Francisco X Real, Almudena R Ramiro
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 10, Pp 1327-1336 (2015)
Abstract Activation‐induced deaminase (AID) initiates secondary antibody diversification in germinal center B cells, giving rise to higher affinity antibodies through somatic hypermutation (SHM) or to isotype‐switched antibodies through class swi
Externí odkaz:
https://doaj.org/article/f845f41e876b414eaa2cf320fdb7f77d
Autor:
David M. Tarlinton, Theresa Börsig, Thomas Wossning, David Medgyesi, Aparajita Singh, Elmar Dolezal, Simona Infantino, Susana Minguet, Hassan Jumaa, Friedel Drepper, Michael Reth, Gina J. Fiala, Bettina Warscheid
Publikováno v:
Nature Immunology. 18:911-920
Developing pre-B cells in the bone marrow alternate between proliferation and differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B cell translocation gene 2 (BTG2) are critical components of the pre-B cell differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89500184b03cb33f40692a9092af543c
https://doi.org/10.1038/ni.3774
https://doi.org/10.1038/ni.3774
Autor:
Marcus Dühren-von Minden, Michael Reth, Thomas Wossning, Martina P. Bach, Kohei Kometani, Hassan Jumaa, Anselm H. C. Horn, Rudolf Übelhart, Tomohiro Kurosaki, Eva Hug, Christoph J. Binder, Dimitrios Tsiantoulas, Heinrich Sticht, Lars Nitschke
Publikováno v:
Nature Immunology. 16:534-543
Mature B cells express immunoglobulin M (IgM)- and IgD-isotype B cell antigen receptors, but the importance of IgD for B cell function has been unclear. By using a cellular in vitro system and corresponding mouse models, we found that antigens with l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4008f32625c3b509f6c38a56cf348193
https://doi.org/10.1038/ni.3141
https://doi.org/10.1038/ni.3141
Autor:
Eva Hug, Hassan Jumaa, Markus Werner, Sebastian Herzog, Thomas Wossning, Hemin Faraidun, Fabian Kohler, Cathrin Eschbach, Alabbas Alkhatib
Publikováno v:
The Journal of Experimental Medicine
During murine B cell development, PI3 kinase inhibits Ig gene rearrangement by suppressing FoxO1, which mediates Ikaros mRNA splicing; Ikaros is needed for Ig gene recombination.
Somatic rearrangement of immunoglobulin (Ig) genes is a key step d
Somatic rearrangement of immunoglobulin (Ig) genes is a key step d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef22df6b6ff76b8e50bed57d70c88401
https://doi.org/10.1084/jem.20110216
https://doi.org/10.1084/jem.20110216
Autor:
Thomas Wossning, Fabian Kohler, Markus Müschen, Sonja Meixlsperger, Michael Reppel, Hassan Jumaa
Publikováno v:
Immunity. 26(3):323-333
Signals from the B cell antigen receptor (BCR), consisting of mu heavy chain (muHC) and conventional light chain (LC), and its precursor the pre-BCR, consisting of muHC and surrogate light chain (SLC), via the adaptor protein SLP-65 regulate the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba2e78c02f378a0cc19140cc0f10061
Autor:
Thomas Wossning, Michael Reth
Publikováno v:
Immunology Letters. 92:67-73
Signal transduction from the B cell antigen receptor (BCR) involves a multitude of signaling molecules often organized in dynamic protein complexes. The molecular mechanisms operating during signaling are difficult to study solely by loss-of-function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e1e525e2fa94e4cb994122fadf6bbc
https://doi.org/10.1016/j.imlet.2003.10.015
https://doi.org/10.1016/j.imlet.2003.10.015
Publikováno v:
The Journal of Experimental Medicine
SLP-65-/- pre-B cells show a high proliferation rate in vitro. We have shown previously that lambda5 expression and consequently a conventional pre-B cell receptor (pre-BCR) are essential for this proliferation. Here, we show that pre-B cells express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fc5207e64d46838b62f853d21c34eb
https://doi.org/10.1084/jem.20031428
https://doi.org/10.1084/jem.20031428
Autor:
Maike Gallwitz, Christa Zürn, Alexandra Flemming, Wolfgang W. A. Schamel, Thomas Wossning, Michael Reth, Véronique Rolli
Publikováno v:
Molecular Cell. 10:1057-1069
We have established a protocol allowing transient and inducible coexpression of many foreign genes in Drosophila S2 Schneider cells. With this powerful approach of reverse genetics, we studied the interaction of the protein tyrosine kinases Syk and L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5fb82187c1ecaaede3cd897135f739
https://doi.org/10.1016/s1097-2765(02)00739-6
https://doi.org/10.1016/s1097-2765(02)00739-6
Autor:
Daniel Hofmann, Marie Follo, Martina P. Bach, Elena Surova, Maike Buchner, Thomas Wossning, Rudolf Übelhart, Hedda Wardemann, Katja Zirlik, Hendrik Veelken, Marcus Dühren-von Minden, Hassan Jumaa, Fabian Kohler, Dunja Schneider
Publikováno v:
Nature, 489(7415), 309
B-cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL) is found not to be dependent on exogenous antigens; instead, signalling may involve the binding of the BCR heavy-chain complementarity-determining region to self epitopes on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c327ad41a180e49d626e33882c99569a
https://pubmed.ncbi.nlm.nih.gov/22885698
https://pubmed.ncbi.nlm.nih.gov/22885698
Autor:
Michael Reth, Thomas Wossning, Hassan Jumaa, Martina P. Bach, Cathrin Eschbach, Rudolf Übelhart
Publikováno v:
Nature immunology. 11(8)
Developing B cells express distinct classes of B cell antigen receptors (BCRs) that differ in their heavy chain (HC). Although only muHC is expressed in early stages, deltaHC-containing BCRs dominate on the surface of mature B cells. The reason for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0b885b052b10731e0ce5227658af05
https://pubmed.ncbi.nlm.nih.gov/20622883
https://pubmed.ncbi.nlm.nih.gov/20622883