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Autor:
Gerrit Wolters-Eisfeld, Baris Mercanoglu, Bianca T. Hofmann, Thomas Wolpers, Claudia Schnabel, Sönke Harder, Pascal Steffen, Kai Bachmann, Babett Steglich, Jörg Schrader, Nicola Gagliani, Hartmut Schlüter, Cenap Güngör, Jakob R. Izbicki, Christoph Wagener, Maximilian Bockhorn
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 10, Pp 1-13 (2018)
Pancreatic disorders: when protein modification misfires Reduced levels of a protein called Cosmc in the pancreas may lead to pancreatic disorders and a rare form of diabetes. Disruption to glycosylation, the process by which carbohydrates are added
Externí odkaz:
https://doaj.org/article/e4cd471544554380848bc885224144b7
Autor:
Bianca T. Hofmann, Babett Steglich, Nicola Gagliani, Jörg Schrader, Kai Bachmann, Hartmut Schlüter, Thomas Wolpers, Baris Mercanoglu, Christoph Wagener, Jakob R. Izbicki, Cenap Güngör, Sönke Harder, Claudia Schnabel, Pascal Steffen, Gerrit Wolters-Eisfeld, Maximilian Bockhorn
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 10, Pp 1-13 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c77ca6ef1288fcdd3b7f91aaf219c67
https://doaj.org/article/e4cd471544554380848bc885224144b7
https://doaj.org/article/e4cd471544554380848bc885224144b7