Výsledky vyhledávání - "Thomas Wollert"

Akademický článek

TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes

Autor: Lisa Wetzel, Stéphane Blanchard, Sowmya Rama, Viola Beier, Anna Kaufmann, Thomas Wollert

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Many neurodegenerative disorders are characterised by the accumulation of protein aggregates in neurons. Here, the authors show that the lysosomal protein TECPR1 selectively recruits mature autophagosomes via an interaction with LC3C to break down pr

Externí odkaz: https://doaj.org/article/d29a27c14ad747c795c581cc170d175d

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Akademický článek

Atg11 tethers Atg9 vesicles to initiate selective autophagy.

Autor: Nena Matscheko, Peter Mayrhofer, Yijian Rao, Viola Beier, Thomas Wollert

Publikováno v: PLoS Biology, Vol 17, Iss 7, p e3000377 (2019)

Autophagy recycles cytoplasmic components by sequestering them in double membrane-surrounded autophagosomes. The two proteins Atg11 and Atg17 are scaffolding components of the Atg1 kinase complex. Atg17 recruits and tethers Atg9-donor vesicles, and t

Externí odkaz: https://doaj.org/article/6e80543085e64893bc99d1dac9ec4fed

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Akademický článek

The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy

Autor: Yijian Rao, Marco G. Perna, Benjamin Hofmann, Viola Beier, Thomas Wollert

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Autophagosome biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. Here Rao et al. use a reconstituted in vitrosystem to describe the mechanism by which activation of the Atg1-kinase complex from its constituent pa

Externí odkaz: https://doaj.org/article/df0bd52b826c4a808f835fa5eb6cec06

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Don't forget to be picky – selective autophagy of protein aggregates in neurodegenerative diseases

Autor: Anne Simonsen, Thomas Wollert

Publikováno v: Current Opinion in Cell Biology
Current Opinion in Cell Biology, 2022, 75, pp.102064. ⟨10.1016/j.ceb.2022.01.009⟩

International audience; The homeostasis of cells depends on the selective degradation of damaged or superfluous cellular components. Autophagy is the major pathway that recognizes such components, sequesters them in de novo formed autophagosomes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cfce53bd032e99a78ab2d167880c17
https://hal-pasteur.archives-ouvertes.fr/pasteur-04047116

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Phagophore formation by the autophagy conjugation machinery

Autor: Jagan Mohan, Christine Girard Blanc, Satish Moparthi, Charlotte Nugues, Sowmya Rama, Stéphane Vassilopoulos, Thomas Wollert

Autophagy is a fundamental cellular recycling pathway that captures cytoplasmic material by a phagophore membrane and delivers it to lysosomes for degradation. Nonselective phagophores are generated at specialized ER-domains termed omegasomes. Mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2422eaa9fb16f3dad7b65c604e8ac0c8
https://doi.org/10.21203/rs.3.rs-1269772/v1

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TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes

Autor: Anna Kaufmann, Stéphane Blanchard, Sowmya Rama, Viola Beier, Lisa Wetzel, Thomas Wollert

Publikováno v: NATURE COMMUNICATIONS
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2993. ⟨10.1038/s41467-020-16689-5⟩
Nature Communications, 2020, 11 (1), pp.2993. ⟨10.1038/s41467-020-16689-5⟩
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

The accumulation of protein aggregates is involved in the onset of many neurodegenerative diseases. Aggrephagy is a selective type of autophagy that counteracts neurodegeneration by degrading such aggregates. In this study, we found that LC3C coopera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938af4d5094bf8e2d5531ba0dc829175
https://hdl.handle.net/21.11116/0000-0006-BA7D-D21.11116/0000-0006-BA7F-B

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Autophagy

Autor: Thomas Wollert

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2019, 29 (14), pp.R671-R677. ⟨10.1016/j.cub.2019.06.014⟩
Current Biology-CB, 2019, 29 (14), pp.R671-R677. ⟨10.1016/j.cub.2019.06.014⟩
Current Biology

International audience; In 1955, the biologist and Nobel Prize laureate Christian de Duve discovered that cells possess specialized organelles filled with hydrolytic enzymes and he called these organelles lysosomes. At the same time, electron microsc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1dea30f76dda914e8431134ddef5ba
https://hal-pasteur.archives-ouvertes.fr/pasteur-02866330/document

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Reconstituting Autophagy Initiation from Purified Components

Autor: Peter, Mayrhofer, Thomas, Wollert

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1880

The hallmark of macroautophagy is the de novo generation of a membrane structure that collects cytoplasmic material and delivers it to lysosomes for degradation. The nucleation of this precursor membrane, termed phagophore, involves the coordinated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4086ce07189d6631cd049f925c555c2e
https://pubmed.ncbi.nlm.nih.gov/30610692

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Reconstituting Autophagy Initiation from Purified Components

Autor: Peter Mayrhofer, Thomas Wollert

Publikováno v: Autophagy
Autophagy, 1880, Springer New York, pp.119-133, 2019, Methods in Molecular Biology, 978-1-4939-8873-0. ⟨10.1007/978-1-4939-8873-0_6⟩
Methods in Molecular Biology ISBN: 9781493988723

International audience; The hallmark of macroautophagy is the de novo generation of a membrane structure that collects cytoplasmic material and delivers it to lysosomes for degradation. The nucleation of this precursor membrane, termed phagophore, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749e96a20a538ec6971f885706d4c236
https://hal.science/hal-04050949

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Reconstruction of destruction

Autor: Satish Babu, Moparthi, Thomas, Wollert

Publikováno v: Journal of cell science. 132(4)

Autophagy is one of the most elaborative membrane remodeling systems in eukaryotic cells. Its major function is to recycle cytoplasmic material by delivering it to lysosomes for degradation. To achieve this, a membrane cisterna is formed that gradual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::931320b1333762b69830f9741c3cbd6c
https://pubmed.ncbi.nlm.nih.gov/30381358

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