Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running.

Autor: Simon Lønbro, Jennifer M Wiggins, Thomas Wittenborn, Pernille Byrialsen Elming, Lori Rice, Christine Pampo, Jennifer A Lee, Dietmar W Siemann, Michael R Horsman

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0215584 (2019)

Exercise has long been known to be beneficial to human health. Studies aimed at understanding the effects of exercise specifically focus on predetermined exercise intensities defined by measuring the aerobic capacity of each individual. Many disease

Externí odkaz: https://doaj.org/article/524b473914884e219c94743586d0cac4

A combretastatin-mediated decrease in neutrophil concentration in peripheral blood and the impact on the anti-tumor activity of this drug in two different murine tumor models.

Autor: Anja Bille Bohn, Thomas Wittenborn, Anne Sofie Brems-Eskildsen, Tinne Laurberg, Lotte Bonde Bertelsen, Thomas Nielsen, Hans Stødkilde-Jørgensen, Bjarne Kuno Møller, Michael R Horsman

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110091 (2014)

The vascular disrupting agent combretastatin A-4 disodium phosphate (CA4P) induces fluctuations in peripheral blood neutrophil concentration. Because neutrophils have the potential to induce both vascular damage and angiogenesis we analyzed neutrophi

Externí odkaz: https://doaj.org/article/21e0b07b9d484657b7b20f35874a04a4

Characterization of DNA–protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus

Autor: Mingdong Dong, Holger Jon Møller, Thomas Wittenborn, Duncan S. Sutherland, Henrik Jensen, Søren E. Degn, Kristian Juul-Madsen, Kristian Stengaard-Pedersen, Huaying Zhao, Mads Axelsen, Anne Troldborg, Thomas Vorup-Jensen, Peter Schuck, Steffen Thiel, Lasse Hyldgaard Klausen, Søren R. Paludan, Stefanie Luecke

Publikováno v: Juul-Madsen, K, Troldborg, A, Wittenborn, T R, Axelsen, M G, Zhao, H, Klausen, L H, Luecke, S, Paludan, S R, Stengaard-Pedersen, K, Dong, M, Møller, H J, Thiel, S, Jensen, H, Schuck, P, Sutherland, D S, Degn, S E & Vorup-Jensen, T 2021, ' Characterization of DNA–protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 30, e2106647118 . https://doi.org/10.1073/pnas.2106647118
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 30
Juul-Madsen, K, Troldborg, A, Wittenborn, T R, Axelsen, M G, Zhao, H, Klausen, L H, Luecke, S, Paludan, S R, Stengaard-Pedersen, K, Dong, M, Møller, H J, Thiel, S, Jensen, H, Schuck, P, Sutherland, D S, Degn, S E & Vorup-Jensen, T 2021, ' Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 30, e2106647118 . https://doi.org/10.1073/pnas.2106647118

Nanotechnology enables investigations of single biomacromolecules, but technical challenges have limited the application in liquid biopsies, for example, blood plasma. Nonetheless, tools to characterize single molecular species in such samples repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299cd75e5538006f281aafb6acc5356a
https://curis.ku.dk/portal/da/publications/characterization-of-dnaprotein-complexes-by-nanoparticle-tracking-analysis-and-their-association-with-systemic-lupus-erythematosus(b3c30848-1173-4887-a679-7e5f4d96aaa8).html

Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents

Autor: Patricia Switten Nielsen, Pernille B. Elming, Thomas Wittenborn, Michael R. Horsman

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 13
Horsman, M R, Wittenborn, T R, Nielsen, P S & Elming, P B 2020, ' Tumors resistant to checkpoint inhibitors can become sensitive after treatment with vascular disrupting agents ', International Journal of Molecular Sciences, vol. 21, no. 13, 4778, pp. 1-14 . https://doi.org/10.3390/ijms21134778
International Journal of Molecular Sciences, Vol 21, Iss 4778, p 4778 (2020)

Immune therapy improves cancer outcomes, yet many patients do not respond. This pre-clinical study investigated whether vascular disrupting agents (VDAs) could convert an immune unresponsive tumor into a responder. CDF1 mice, with 200 mm3 C3H mammary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e94edc3eb03b48ba75e0ae2b464494

OC-0202: Combining hyperthermia or a VDA with checkpoint inhibitors to increase tumour immunogenicity

Autor: P.B. Elming, Michael R. Horsman, Thomas Wittenborn

Publikováno v: Radiotherapy and Oncology. 152:S101-S102

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdce12f113ad1487330a8476d1d1245b
https://doi.org/10.1016/s0167-8140(21)00226-7