Zobrazeno 1 - 10
of 1 034
pro vyhledávání: '"Thomas Wirth"'
Autor:
Lars Mohren, Friedrich Erdlenbruch, Elsa Leitão, Fabian Kilpert, G. Sebastian Hönes, Sabine Kaya, Christopher Schröder, Andreas Thieme, Marc Sturm, Joohyun Park, Agatha Schlüter, Montserrat Ruiz, Moisés Morales de la Prida, Carlos Casasnovas, Kerstin Becker, Ulla Roggenbuck, Sonali Pechlivanis, Frank J. Kaiser, Matthis Synofzik, Thomas Wirth, Mathieu Anheim, Tobias B. Haack, Paul J. Lockhart, Karl-Heinz Jöckel, Aurora Pujol, Stephan Klebe, Dagmar Timmann, Christel Depienne
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Repeat expansions in FGF14 cause autosomal dominant late-onset cerebellar ataxia (SCA27B) with estimated pathogenic thresholds of 250 (incomplete penetrance) and 300 AAG repeats (full penetrance), but the sequence of pathogenic and non-patho
Externí odkaz:
https://doaj.org/article/6570a285e9844430857f2e885f205ade
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Electrochemistry offers tunable, cost effective and environmentally friendly alternatives to carry out redox reactions with electrons as traceless reagents. The use of organoiodine compounds as electrocatalysts is largely underdeveloped, des
Externí odkaz:
https://doaj.org/article/c5c221bd87a54b2abce5ce6d69ef90c1
Autor:
Miltiadis Tsesmelis, Ulrike F. G. Büttner, Melanie Gerstenlauer, Uta Manfras, Konstantinos Tsesmelis, Ziwei Du, Nadine Sperb, Stephanie Ellen Weissinger, Peter Möller, Thomas F. E. Barth, Harald J. Maier, Lap Kwan Chan, Thomas Wirth
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is marked by a dismal survival rate, lacking effective therapeutics due to its aggressive growth, late-stage diagnosis, and chemotherapy resistance. Despite debates on NF-κB targeting for P
Externí odkaz:
https://doaj.org/article/d60de3829ea54fce943d4b1ee9fe0c20
Autor:
Ohud Alzaidi, Thomas Wirth
Publikováno v:
ACS Organic & Inorganic Au, Vol 4, Iss 3, Pp 350-355 (2024)
Externí odkaz:
https://doaj.org/article/7e58147f050a49ec9eb7db3fa7161e6a
Autor:
Ester Nespoli, Marsela Hakani, Tabea Melissa Hein, Stephanie Nadine May, Karin Danzer, Thomas Wirth, Bernd Baumann, Leda Dimou
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Acute neuroinflammation is a prominent reaction after TBI and is mostly initiated by brain-resident glial cells such as microglia, NG2-glia and astrocytes
Externí odkaz:
https://doaj.org/article/edffa25bd6804772b892660c32c48f57
Autor:
Matthieu Béreau, Anna Castrioto, Mathieu Servant, Eugénie Lhommée, Maxime Desmarets, Amélie Bichon, Pierre Pélissier, Emmanuelle Schmitt, Hélène Klinger, Nadine Longato, Clélie Phillipps, Thomas Wirth, Valérie Fraix, Isabelle Benatru, Franck Durif, Jean-Philippe Azulay, Elena Moro, Emmanuel Broussolle, Stéphane Thobois, Christine Tranchant, Paul Krack, Mathieu Anheim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Few studies have considered the influence of motor sign asymmetry on motivated behaviors in de novo drug-naïve Parkinson’s disease (PD). We tested whether motor sign asymmetry could be associated with different motivated behavior patterns
Externí odkaz:
https://doaj.org/article/9e0fb56849fe48b1af8773b3bcc91c8c
Autor:
Nora Möhn, Susann Mahjoub, Laura Duzzi, Emily Narten, Lea Grote‐Levi, Gudrun Körner, Tabea Seeliger, Gernot Beutel, Benjamin‐Alexander Bollmann, Thomas Wirth, André Huss, Hayrettin Tumani, Imke Grimmelmann, Ralf Gutzmer, Philipp Ivanyi, Thomas Skripuletz, ICOG‐CCCH (Immune Cooperative Oncology Group; Comprehensive Cancer Center Hannover)
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9373-9383 (2023)
Abstract Background Oncological patients can benefit substantially from treatment with immune checkpoint inhibitors (ICI). However, there is a growing awareness of immune‐related adverse events (irAE). Especially ICI‐mediated neurological adverse
Externí odkaz:
https://doaj.org/article/fc59d8e698d2445d874c2607cff2f8e4
Autor:
Judith Stefanie Schlett, Melanie Mettang, Aladdin Skaf, Pavel Schweizer, Alina Errerd, Ephraim Alemayehu Mulugeta, Tabea Melissa Hein, Konstantinos Tsesmelis, Miltiadis Tsesmelis, Ulrike F. G. Büttner, Heinrich Wendt, Alireza Abaei, Volker Rasche, Vivien Prex, Ester Nespoli, Najwa Ouali Alami, Daniel Tews, Paul Walther, Deniz Yilmazer-Hanke, Franz Oswald, Leda Dimou, Thomas Wirth, Bernd Baumann
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-24 (2023)
Abstract Background Inflammaging represents an accepted concept where the immune system shifts to a low-grade chronic pro-inflammatory state without overt infection upon aging. In the CNS, inflammaging is mainly driven by glia cells and associated wi
Externí odkaz:
https://doaj.org/article/dadf10c5cb834709b7cfc8b0ca998b3f
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 27-32 (2023)
We describe a multi-step continuous-flow procedure for the generation of six-membered diaryliodonium salts. The accompanying scalability and atom economy are significant improvements to existing batch methods. Benzyl acetates are submitted to this tw
Externí odkaz:
https://doaj.org/article/58e263806e4643b28de3c93d7a47df66
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16472 (2023)
Menin/MEN1 is a scaffold protein that participates in proliferation, regulation of gene transcription, DNA damage repair, and signal transduction. In hematological malignancies harboring the KMT2A/MLL1 (MLLr) chromosomal rearrangements, the interacti
Externí odkaz:
https://doaj.org/article/9cde7b184d6040a9a4f23dc5b0618c0c