Zobrazeno 1 - 10
of 582
pro vyhledávání: '"Thomas Williams, A."'
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 9, Pp 2372-2381 (2024)
Abstract Objectives Hypoperfusion and tissue hypoxia have been implicated as contributory mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to study cortical oxygenation in vivo in patients with MS and age‐matched
Externí odkaz:
https://doaj.org/article/73805677220743bfafcb3ade5d5462dc
Autor:
Ryan Thomas Williams
Publikováno v:
Frontiers in Research Metrics and Analytics, Vol 9 (2024)
Technology has mostly been embraced in qualitative research as it has not directly conflicted with qualitative methods' paradigmatic underpinnings. However, Artificial Intelligence (AI), and in particular the process of automating the analysis of qua
Externí odkaz:
https://doaj.org/article/8284372222c84557b1713cd3ab9bd81a
Autor:
Haneen S. Alsehli, Errin Roy, Thomas Williams, Alicja Kuziola, Yunzhe Guo, Cecile A. Dreiss, Jeremy B.A. Green, Eileen Gentleman, Davide Danovi
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionCell lineage specification is tightly associated with profound morphological changes in the developing human embryo, particularly during gastrulation. The interplay between mechanical forces and biochemical signals is poorly understood.Me
Externí odkaz:
https://doaj.org/article/b25bac5cac2a45629d828abf4aa2484d
Autor:
Alan J Thompson, Charles Wade, Nevin John, Jeremy Chataway, Gavin Giovannoni, Rachael Hunter, Sreedharan Harikrishnan, Floriana De Angelis, Olga Ciccarelli, Eli Silber, John Greenwood, Thomas Williams, Martin Duddy, Basil Sharrack, Annie Hawton, Siddharthan Chandran, Sue Pavitt, Paul Gallagher, Ian Galea, Jennifer M Nicholas, Tarunya Arun, Miriam Mattoscio, Richard Nicholas, Neil Robertson, Carolyn Young, Jeremy Hobart, David Rog, Owen Pearson, Anisha Doshi, Timothy Harrower, Leonora Fisniku, Ruth Geraldes, Nikos Evangelou, Judy Beveridge, Matthew Craner, Don Mahad, Stefano Pluchino, Suresh Chhetri, Susan Tebbs, Marie Braisher, Seema Kalra, Charles Hillier, Chris Frost, Gavin McDonnell, Stuart J Nixon, Helen L Ford, Jeban Ganesalingam, Claire Rice, Alberto Calvi, Cord Spilker, Abdullah Shehu, Martin Lee, James Blackstone, Alessia Bianchi, Agne Straukiene, Gil Barton, Fayyaz Ahmed, Dawn Lyle, Ekaterina Bordea, Sean Apap Mangion, Rachel Merry, Elisabeth Jarman
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Introduction There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, the MS-STAT2 phase 3 tria
Externí odkaz:
https://doaj.org/article/69619bde66e34a6986cbeaf0b8bdc802
Autor:
Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David MacManus, Francesco Grussu, Anita Karsa, Becky Samson, Marco Battiston, Claudia A.M. Gandini Wheeler-Kingshott, Karin Shmueli, Olga Ciccarelli, Frederik Barkhof, Jeremy Chataway, Wallace Brownlee, Claudia AM. Gandini Wheeler-Kingshott, Jonathan Stutters, Ferran Prados Carrasco, Marios Yiannakas, Megan Wynne, Marie Braisher, James Blackstone, Leanne Hockey, Josephine Parker, Jennifer Flight, Chris Frost, Jennifer Nicholas, Stuart Nixon, Judy Beveridge
Publikováno v:
Neuroimage: Reports, Vol 4, Iss 3, Pp 100216- (2024)
Background: Deep grey matter pathology is a key driver of disability worsening in people with multiple sclerosis. Quantitative susceptibility mapping (QSM) is an advanced magnetic resonance imaging (MRI) technique which quantifies local magnetic susc
Externí odkaz:
https://doaj.org/article/a5f0c83cc2dc4adf9dbc117e4d8f1ca0
Autor:
Nevin John, Jeremy Chataway, Jacqueline Palace, Gavin Giovannoni, David Paling, Frederik Barkhof, Floriana De Angelis, Lorraine Smith, Thomas Williams, Martin Duddy, James Overell, Basil Sharrack, Sebastien Ourselin, Allan Walker, Siddharthan Chandran, Richard Nicholas, Shuna Colville, Peter Connick, Carolyn Young, Jeremy Hobart, Anisha Doshi, Sharmilee Gnanapavan, Helen Ford, Baljean Dhillon, Thanh Phan, Arman Eshaghi, Julia Aram, Nigel Stallard, James Cameron, Brendan McLean, Matthew Craner, Domenico Plantone, Jonathan Stutters, Ferran Prados Carrasco, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Clive Hawkins, Roger Bastow, Daisy Mollison, Waqar Rashid, Joe Guadagno, Nikolaos Evangelou, Seema Kalra, Alberto Calvi, Yingtong Li, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, Heinke Arndt
Publikováno v:
BMJ Neurology Open, Vol 6, Iss 2 (2024)
Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain reserve, has been associated with reduced p
Externí odkaz:
https://doaj.org/article/03779c5cc9264a67966bb74f4a5ef24d
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012264 (2024)
The role of direct cell-to-cell spread in viral infections-where virions spread between host and susceptible cells without needing to be secreted into the extracellular environment-has come to be understood as essential to the dynamics of medically s
Externí odkaz:
https://doaj.org/article/974dc7b289e04fcd8cc2c40fa06d1451
Autor:
Thomas Williams-Fegredo, Lee Davies, Carol Knevelman, Kyriacos Mitrophanous, James Miskin, Qasim A. Rafiq
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Both cell surface and soluble extracellular glycosaminoglycans have been shown to interfere with the exogenous nucleic acid delivery efficiency of non-viral gene delivery, including lipoplex and polyplex-mediated transfection. Most gene therapy viral
Externí odkaz:
https://doaj.org/article/30f18ce1f17f438ab64d69f10643272c
Autor:
Thomas Williams-Fegredo, Lee Davies, Carol Knevelman, Kyriacos Mitrophanous, James Miskin, Qasim A. Rafiq
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101260- (2024)
Large-scale transient transfection has advanced significantly over the last 20 years, enabling the effective production of a diverse range of biopharmaceutical products, including viral vectors. However, a number of challenges specifically related to
Externí odkaz:
https://doaj.org/article/3197910bb8934f0bb12e559c15fef757
Autor:
Juno Obedin-Maliver, Carolyn Hunt, Annesa Flentje, Cassie Armea-Warren, Mahri Bahati, Micah Lubensky, Zubin Dastur, Chloe Eastburn, Ell Hundertmark, Daniel Moretti, Anthony Pho, Ana Rescate, Richard E. Greene, Philip-Jamal Thomas Williams, Devin Hursey, Loree Cooke Daniels, Mitchell Lunn
Publikováno v:
Journal of Community Engagement and Scholarship, Vol 16, Iss 2 (2024)
Lesbian, gay, bisexual, transgender, queer, intersex, asexual, aromantic, and other sexual and/or gender minority (LGBTQIA+) communities are underrepresented in health research and subject to documented health disparities. In addition, LGBTQIA+ commu
Externí odkaz:
https://doaj.org/article/4d17dbc767d04e6ca66f32dc4a5ebfae