Zobrazeno 1 - 10
of 687
pro vyhledávání: '"Thomas Werfel and"'
Autor:
Alice Pereira da Fonseca, Stephan Traidl, Ralf Gutzmer, Katrin Schaper-Gerhardt, Thomas Werfel, Susanne Mommert
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Beyond Th2 cells and various immune cells, M2 macrophages have been identified in lesional skin of atopic dermatitis (AD) indicating their involvement in the disease’s underlying mechanisms. MMP12, a matrix-degrading enzyme, which is predominantly
Externí odkaz:
https://doaj.org/article/6e819d9109aa4ec8b03f8b773d396cdc
Autor:
Javier Botey-Bataller, Hedwig D. Vrijmoeth, Jeanine Ursinus, Bart-Jan Kullberg, Cees C. van den Wijngaard, Hadewych ter Hofstede, Ahmed Alaswad, Manoj K. Gupta, Lennart M. Roesner, Jochen Huehn, Thomas Werfel, Thomas F. Schulz, Cheng-Jian Xu, Mihai G. Netea, Joppe W. Hovius, Leo A. B. Joosten, Yang Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine production capacity before an
Externí odkaz:
https://doaj.org/article/e3dcc9f358504f8d8994380adb860b5e
Autor:
Goran Abdurrahman, Rebecca Pospich, Leif Steil, Manuela Gesell Salazar, Juan José Izquierdo González, Nicole Normann, Daniel Mrochen, Christian Scharf, Uwe Völker, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner, Lidia Gómez-Gascón
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAtopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with skin barrier defects and a misdirected type 2 immune response against harmless antigens. The skin microbiome in AD is characterized by a reduction in microbial di
Externí odkaz:
https://doaj.org/article/2ffbfd599c934f85a83ca84c7246d9c5
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract A subgroup of patients suffering from atopic dermatitis (AD) does not respond to biologics therapy targeting the key players of type-2 inflammation, and it is an ongoing discussion whether skin-infiltrating Th17 cells may underlie this pheno
Externí odkaz:
https://doaj.org/article/8e63efe9a2b0422f83689c662b1c4a5a
Autor:
Anissa Fries, Fanny Saidoune, François Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermedia
Externí odkaz:
https://doaj.org/article/9a6badc4e12148d591a4960524014626
Autor:
Jacob P. Thyssen, Thomas Werfel, Sebastien Barbarot, Hamish J.A Hunter, Evangeline Pierce, Luna Sun, Lisa Cirri, Andrew S. Buchanan, Na Lu, Andreas Wollenberg
Publikováno v:
Journal of Dermatological Treatment, Vol 34, Iss 1 (2023)
Background Patients who completed the originating studies, BREEZE-AD1 (NCT03334396), BREEZE-AD2(NCT03334422), and BREEZE-AD7 (NCT03733301), were eligible for enrollment in the multicenter,phase-3, long-term extension study BREEZE-AD3 (NCT03334435). M
Externí odkaz:
https://doaj.org/article/c4c894e54c7248608b959261c2cae564
Publikováno v:
Bio-Protocol, Vol 13, Iss 22 (2023)
Externí odkaz:
https://doaj.org/article/b6b1de82596f42ac90a82475dc9cd83d
Publikováno v:
Bio-Protocol, Vol 13, Iss 20 (2023)
Platelets and their activation status play an essential role in cancer metastasis. Therefore, the anti-metastatic potential of antiplatelet drugs has been investigated for many years. However, the initial screening of these antiplatelet drugs to dete
Externí odkaz:
https://doaj.org/article/0163d44a9740445089b165a322675fde
Autor:
Torsten Zuberbier, Amir Abdul Latiff, Xenofon Aggelidis, Matthias Augustin, Radu‐Gheorghe Balan, Christine Bangert, Lisa Beck, Thomas Bieber, Jonathan A. Bernstein, Marta Bertolin Colilla, Alejandro Berardi, Anna Bedbrook, Carsten Bindslev‐Jensen, Jean Bousquet, Marjolein deBruin‐Weller, Dayanne Bruscky, Betul Buyuktiryaki, Giorgio Walter Canonica, Carla Castro, Natia Chanturidze, Herberto Jose Chong‐Neto, Chia‐Yu Chu, Leena Chularojanamontri, Michael Cork, Roberta F. J. Criado, Laia Curto Barredo, Adnan Custovic, Ulf Darsow, Arben Emurlai, Ana dePablo, Stefano DelGiacco, Giampiero Girolomoni, Tanja Deleva Jovanova, Mette Deleuran, Nikolaos Douladiris, Bruno Duarte, Ruta Dubakiene, Esben Eller, Batya Engel‐Yeger, Luis Felipe Ensina, Nelson Rosario Filho, Carsten Flohr, Daria Fomina, Wojciech Francuzik, Maria Laura Galimberti, Ana M. Giménez‐Arnau, Kiran Godse, Charlotte Gotthard Mortz, Maia Gotua, Michihiro Hide, Wolfram Hoetzenecker, Nicolas Hunzelmann, Alan Irvine, Carolyn Jack, Ioanna Kanavarou, Norito Katoh, Tamar Kinaciyan, Emek Kocatürk, Kanokvalai Kulthanan, Hilde Lapeere, Susanne Lau, Mariana Machado Forti Nastri, Michael Makris, Eli Mansour, Alexander Marsland, Mara Morelo Rocha Felix, Ana Paula Moschione Castro, Eustachio Nettis, J. F. Nicolas, Audrey Nosbaum, Mikaela Odemyr, Niki Papapostolou, Claudio A. S. Parisi, Sushil Paudel, Jonny Peter, Prakash Pokharel, Luis Puig, Tamara Quint, German Dario Ramon, Frederico Regateiro, Giampaolo Ricci, Cristine Rosario, Cansin Sackesen, Peter Schmid‐Grendelmeier, Esther Serra‐Baldrich, Kristina Siemens, Cathrine Smith, Petra Staubach, Katarina Stevanovic, Özlem Su‐Kücük, Gordon Sussman, Simona Tavecchio, Natasa Teovska Mitrevska, Diamant Thaci, Elias Toubi, Claudia Traidl‐Hoffmann, Regina Treudler, Zahava Vadasz, Ingrid vanHofman, Maria Teresa Ventura, Zhao Wang, Thomas Werfel, Andreas Wollenberg, Ariana Yang, Yik Weng Yew, Zuotao Zhao, Ricardo Zwiener, Margitta Worm
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Introduction The integrated care pathways for atopic dermatitis (AD‐ICPs) aim to bridge the gap between existing AD treatment evidence‐based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary
Externí odkaz:
https://doaj.org/article/f587fd854f5046c2adf094d0da55be12
Autor:
Torsten Zuberbier, Lisa A. Beck, Anna Bedbrook, Marjolein deBruin‐Weller, Jean Bousquet, Michael Cork, Nikolaos Douladiris, Norito Katoh, Charlotte G. Mortz, Thomas Werfel, Francuzik Wojciech, Andreas Wollenberg, Kristina Siemens, Katarina Stevanovic, Margitta Worm, AD‐ICPs Working Group
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 3, Pp n/a-n/a (2023)
Abstract Background GA2LEN‐ADCARE is a branch of the largest multidisciplinary network of research centres and clinical care in allergy and asthma, GA2LEN, focussing on the field of atopic dermatitis (AD). AD is a chronic inflammatory skin disease
Externí odkaz:
https://doaj.org/article/2d30b10d01e546798ba9159a09abe488