Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Thomas Weimbs"'
Autor:
Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Bradley C. Kroes, Tselmeg Amarlkhagva, Matthias M. Haeffner, Elizabeth H. Sharpe, Stella Koestner, Sebastian Strubl, Margaret F. Schimmel, Samantha Kruger, Shagun Agrawal, Brina A. Aceves, Muthusamy Thangaraju, Thomas Weimbs
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110773- (2024)
Summary: Autosomal-dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by the formation of fluid-filled renal cysts, loss of mitochondrial function, decreased fatty acid oxidation, increased glycolysis, and likely r
Externí odkaz:
https://doaj.org/article/c3bcb1d757124a13adea04b7500f77ea
Publikováno v:
Nutrients, Vol 16, Iss 19, p 3281 (2024)
Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights the mismatch between our Paleolithic-optimized genes and modern diets, which led to the dramatically increased prevalence of CKD in modern societies. In pa
Externí odkaz:
https://doaj.org/article/0fd0a4f8325a457ab7ef6080c152706d
Autor:
Jeff S Volek, Shaminie J Athinarayanan, Amy L McKenzie, Caroline G P Roberts, Chandan Vangala, Greeshma K Shetty, Thomas Weimbs
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 12, Iss 2 (2024)
Ketogenic diets have been widely used for weight loss and are increasingly used in the management of type 2 diabetes. Despite evidence that ketones have multiple positive effects on kidney function, common misconceptions about ketogenic diets, such a
Externí odkaz:
https://doaj.org/article/a0c80ddfe9b44968862058840b216968
Autor:
Adrian J. Giovannone, Elena Reales, Pallavi Bhattaram, Sirpi Nackeeran, Adam B. Monahan, Rashid Syed, Thomas Weimbs
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Syntaxins are a family of membrane-anchored SNARE proteins that are essential components required for membrane fusion in eukaryotic intracellular membrane trafficking pathways. Syntaxins contain an N-terminal regulatory domain, termed the Ha
Externí odkaz:
https://doaj.org/article/312ac1bd715e454dbbec8c5acdc7cf54
Autor:
Kanlayanee Tonum, Nipitpon Srimai, Napason Chabang, Somsak Fongsupa, Patoomratana Tuchinda, Jacob A. Torres, Thomas Weimbs, Sunhapas Soodvilai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4328 (2022)
Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-cell proliferation and fluid accumulation. Suppression of these processes may retard the progression of PKD. Evidence suggests that the activation of 5
Externí odkaz:
https://doaj.org/article/691b688d834847e3b9917f800d8ae209
Publikováno v:
Bio-Protocol, Vol 8, Iss 3 (2018)
The uptake and trafficking of cell surface receptors can be monitored by a technique called ‘antibody-feeding’ which uses an externally applied antibody to label the receptor on the surface of cultured, live cells. Here, we adapt the traditional
Externí odkaz:
https://doaj.org/article/64cdce6d749c4d17b548ce94afde5ff9
Autor:
Linda Soo Hoo, Chris D Banna, Carolyn M Radeke, Nikunj Sharma, Mary E Albertolle, Seng Hui Low, Thomas Weimbs, Carol A Vandenberg
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163671 (2016)
Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear. Here we
Externí odkaz:
https://doaj.org/article/249039b348e543288a47019ce92775a9
Autor:
Nicholas Doerr, Yidi Wang, Kevin R Kipp, Guangyi Liu, Jesse J Benza, Vladimir Pletnev, Tengis S Pavlov, Alexander Staruschenko, Ashraf M Mohieldin, Maki Takahashi, Surya M Nauli, Thomas Weimbs
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161525 (2016)
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respe
Externí odkaz:
https://doaj.org/article/2dd1bd64898141e3a8683112f025fee9
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21181 (2011)
Generation of epithelial cell polarity requires mechanisms to sort plasma membrane proteins to the apical and basolateral domains. Sorting involves incorporation into specific vesicular carriers and subsequent fusion to the correct target membranes m
Externí odkaz:
https://doaj.org/article/4c3cdc9d8fd245d08dfaeb708a8254ae
Autor:
Simon Oehm, Konstantin Steinke, Johannes Schmidt, Sita Arjune, Polina Todorova, Christoph Heinrich Lindemann, Fabian Wöstmann, Franziska Meyer, Florian Siedek, Thomas Weimbs, Roman-Ulrich Müller, Franziska Grundmann
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
Background Ketogenic dietary interventions (KDI) have been shown to be effective in animal models of polycystic kidney disease (PKD), but data from clinical trials are lacking. Methods Ten autosomal dominant PKD (ADPKD) patients with rapid disease pr