Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Thomas Walz"'
Publikováno v:
eLife, Vol 12 (2024)
Aquaporin-0 (AQP0) tetramers form square arrays in lens membranes through a yet unknown mechanism, but lens membranes are enriched in sphingomyelin and cholesterol. Here, we determined electron crystallographic structures of AQP0 in sphingomyelin/cho
Externí odkaz:
https://doaj.org/article/da574ef9e6f64e36b5620f82a9a767c6
Autor:
Kemin Tan, Junjian Chen, Yu Kaku, Yi Wang, Luke Donius, Rafiq Ahmad Khan, Xiaolong Li, Hannah Richter, Michael S. Seaman, Thomas Walz, Wonmuk Hwang, Ellis L. Reinherz, Mikyung Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Broadly neutralizing antibodies (bnAbs) against HIV-1 target conserved envelope (Env) epitopes to block viral replication. Here, using structural analyses, we provide evidence to explain why a vaccine targeting the membrane-proximal external
Externí odkaz:
https://doaj.org/article/47bc63ae82264e1ca90081493607b6de
Autor:
Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-huai Wang, Mikyung Kim, Ellis L. Reinherz, Thomas Walz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The membrane-proximal external region of HIV-1 spike protein is a broadly neutralizing antibody target. Here, cryo-electron microscopy and molecular dynamics reveal spontaneous ectodomain tilting, a vulnerability exploitable for vaccine design.
Externí odkaz:
https://doaj.org/article/4c08e89bf0194f2f9406da998e62cf29
Autor:
Daniel Grau, Yixiao Zhang, Chul-Hwan Lee, Marco Valencia-Sánchez, Jenny Zhang, Miao Wang, Marlene Holder, Vladimir Svetlov, Dongyan Tan, Evgeny Nudler, Danny Reinberg, Thomas Walz, Karim-Jean Armache
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucl
Externí odkaz:
https://doaj.org/article/ed6bec3062f3495c95ba56cf7a4fc536
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The bacterial defense system McrBC is a two-component motor-driven nuclease complex that cleaves foreign DNA. Here, the authors present the structures of the GTP-specific AAA + motor protein McrB and two McrBC complexes and discuss the molecular mech
Externí odkaz:
https://doaj.org/article/69657620824b42129488ca2effba60cf
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100053- (2021)
Mechanosensitive (MS) channels that are activated by the ‘force-from-lipids’ (FFL) principle rest in the membrane in a closed state but open a transmembrane pore in response to changes in the transmembrane pressure profile. The molecular implemen
Externí odkaz:
https://doaj.org/article/47ab7ce7f62e47e98fe15b59081ccb28
Autor:
Shuang Yang, Kriti Bahl, Hui-Ting Chou, Jonathan Woodsmith, Ulrich Stelzl, Thomas Walz, Maxence V Nachury
Publikováno v:
eLife, Vol 9 (2020)
Dynamic trafficking of G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome. In concert with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across the transition zone, a diffusion barrier a
Externí odkaz:
https://doaj.org/article/e59a3eff2c394329b90389b66d19d2e9
Autor:
Gabriella Angiulli, Harveer Singh Dhupar, Hiroshi Suzuki, Irvinder Singh Wason, Franck Duong Van Hoa, Thomas Walz
Publikováno v:
eLife, Vol 9 (2020)
Previously we introduced peptidiscs as an alternative to detergents to stabilize membrane proteins in solution (Carlson et al., 2018). Here, we present ‘on-gradient’ reconstitution, a new gentle approach for the reconstitution of labile membrane-
Externí odkaz:
https://doaj.org/article/1aab2e981c6743668b90fb4411a99250
Publikováno v:
Antibiotics, Vol 10, Iss 12, p 1455 (2021)
Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position
Externí odkaz:
https://doaj.org/article/4133e2127277465d86476a885c50e2a4
Autor:
Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A. Lashuel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligom
Externí odkaz:
https://doaj.org/article/a9accbe2206844e88e73f54fa7b62a03