Portal pressure is of significant prognostic value in primary biliary cholangitis

Autor: Thomas W. Warnes, Stephen A. Roberts, Alexander Smith, Victor M. Cope, Patricia Vales, Raymond McMahon

Publikováno v: Warnes, T W, Roberts, S A, Smith, A, Cope, V M, Vales, P & McMahon, R 2022, ' Portal pressure is of significant prognostic value in primary biliary cholangitis ', Liver international : official journal of the International Association for the Study of the Liver . https://doi.org/10.1111/liv.15289

Background and Aims: In other forms of chronic liver disease, measurement of portal pressure is of prognostic value, but this has not yet been established in primary biliary cholangitis (PBC). The aim of the study is to determine the prognostic value

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aeca14c650cd73773b3b7abde98027
https://doi.org/10.1111/liv.15289

Ursodeoxycholic acid in primary biliary cirrhosis improves glutathione status but fails to reduce lipid peroxidation

Autor: Philip W. Pemberton, Alexander C. Smith, Ali Aboutwerat, Thomas W. Warnes

Publikováno v: Redox Report. 11:117-123

Ursodeoxycholic acid (UDCA) may slow progression in primary biliary cirrhosis (PBC), but its effect on survival is controversial. We have previously demonstrated that oxidant stress, with severely depressed plasma glutathione, is a feature of untreat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd754d03ff53740cb13200965471863
https://doi.org/10.1179/135100006x116600

Oxidative stress in chronic hepatitis C: not just a feature of late stage disease

Autor: Sanjiv K. Jain, Thomas W. Warnes, Peter C. Burrows, Raymond Mcmahon, Ali Aboutwerat, Philip W. Pemberton, Alexander Smith

Publikováno v: Journal of Hepatology. 36:805-811

Chronic hepatitis C infection is a major world-wide problem, frequently progressing to cirrhosis, liver failure or hepatoma. The pathological mechanisms of disease progression are unclear but oxidant stress may play a role.Markers of lipid peroxidati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abbb76fb8a7bb98ad03d997b7cf0b2b
https://doi.org/10.1016/s0168-8278(02)00060-0

Serum type III procollagen aminopeptide for assessing liver damage in methotrexate-treated psoriatic patients

Autor: Thomas W. Warnes, Alexander Smith, R.J.G. Chalmers, Maha Shomaf, N.Y. Haboubi, D.M. Mitchell, M. J. Boffa, B.P. Rowan

Publikováno v: British Journal of Dermatology. 135:538-544

This study was designed to establish whether measurement of a serological marker of fibrosis might reduce the need for liver biopsy in psoriatic patients receiving methotrexate (MTX). Levels of type III procollagen aminopeptide (PIIINP-O and PIIINP-B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb78c222656dca5b813dd50864dd53c
https://doi.org/10.1111/j.1365-2133.1996.tb03827.x

Endothelial cell transformation in primary biliary cirrhosis: A morphological and biochemical study

Autor: Alexander Smith, N.Y. Haboubi, Jonathan M. Mellor, C Babbs, Thomas W. Warnes, B.P. Rowan

Publikováno v: Hepatology. 11:723-729

There is increasing interest in the changes of the endothelial lining of the hepatic sinusoids during the development of chronic liver disease. In this study we looked for evidence of hepatic sinusoidal endothelial cell transformation and basement me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fda2045fff8e06a84b20d7441dba340
https://doi.org/10.1002/hep.1840110503