Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Thomas W. Von Geldern"'
Autor:
Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides s
Externí odkaz:
https://doaj.org/article/938a56b59b9342c292856f5bada424f0
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748b270a5ec97aeb6e2aead9a27947b0
https://doi.org/10.1021/acs.jmedchem.1c00034
https://doi.org/10.1021/acs.jmedchem.1c00034
Autor:
Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(4)
A novel diazaspiro[3.4]octane series was identified from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec7cacd693b294b3c6008da32ec3b00e
https://pubmed.ncbi.nlm.nih.gov/33573376
https://pubmed.ncbi.nlm.nih.gov/33573376
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
Autor:
Mark J. Taylor, Marianne Koschel, Stefan J. Frohberger, Thomas W. von Geldern, Kennan C. Marsh, Joseph D. Turner, Achim Hoerauf, Venelin Nikolov, Dominique Struever, Marc P. Hübner, Kenneth Pfarr, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Stephen A. Ward, Dale J. Kempf
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4–6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104b0500b828d5bd3d8c37f076abfd36
https://pubmed.ncbi.nlm.nih.gov/31381563
https://pubmed.ncbi.nlm.nih.gov/31381563
Autor:
Sabine Specht, Thomas W. von Geldern, Kelly L. Johnston, Franziska Lenz, Samuel Wanji, Joseph D. Turner, Nicolas Pionnier, Abdel Jelil Njouendou, Dominique Bloemker, Darren A. N. Cook, Robert A. Carr, Louise Ford, Stephen A. Ward, Mark J. Taylor, Kennan C. Marsh, Marianne Koschel, Hanna T. Sjoberg, Howard E. Morton, Dale J. Kempf, John Archer, Hayley E. Tyrer, Haelly M. Metuge, Fanny Fri Fombad, Ghaith Aljayyoussi, Valerinne C. Chunda, Patrick W. N. Chounna, Rachel H. Clare, Marc P. Hübner, Alexandra Ehrens, Achim Hoerauf, Andrew Steven, Emma A Murphy
Publikováno v:
Science Translational Medicine. 11(483)
There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bf4e4e87aab96ab422a6006d9f9f80
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Mark J, Taylor, Thomas W, von Geldern, Louise, Ford, Marc P, Hübner, Kennan, Marsh, Kelly L, Johnston, Hanna T, Sjoberg, Sabine, Specht, Nicolas, Pionnier, Hayley E, Tyrer, Rachel H, Clare, Darren A N, Cook, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Bloemker, Franziska, Lenz, Marianne, Koschel, Alexandra, Ehrens, Haelly M, Metuge, Valerinne C, Chunda, Patrick W, Ndongmo Chounna, Abdel J, Njouendou, Fanny F, Fombad, Robert, Carr, Howard E, Morton, Ghaith, Aljayyoussi, Achim, Hoerauf, Samuel, Wanji, Dale J, Kempf, Joseph D, Turner, Stephen A, Ward
Publikováno v:
Science translational medicine. 11(483)
There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb5aec0eeb0a980ff0eb7b36977cb89d
https://pubmed.ncbi.nlm.nih.gov/30867321
https://pubmed.ncbi.nlm.nih.gov/30867321
Autor:
Martine Keenan, Eileen Ryan, Scott Cornwall, Andrea Khong, Jason H. Chaplin, Wayne M. Best, Karen L. White, R.C. Andrew Thompson, Catherine J. Perez, Ivan Scandale, Susan A. Charman, Michael J. Abbott, Paul W. Alexander, Francis C. K. Chiu, David M. Shackleford, Michael Campbell, Maria Koltun, Eric Chatelain, Adriana Botero, Julia Morizzi, Thomas W. von Geldern
Publikováno v:
Journal of Medicinal Chemistry
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832ff07aa1233c73b2095f1457b219
https://doi.org/10.1021/jm401610c
https://doi.org/10.1021/jm401610c
Autor:
Martine Keenan, Eileen Ryan, Susan A. Charman, Jason H. Chaplin, Karen L. White, Eric Chatelain, Gong Chen, Jean-Robert Ioset, Zhisen Wang, Michael J. Abbott, Scott Cornwall, Wayne M. Best, Sarah Keatley, Paul W. Alexander, Thomas W. von Geldern, Hugo Diao, Catherine J. Perez, R.C. Andrew Thompson
Publikováno v:
Future Medicinal Chemistry. 5:1733-1752
Background: Inhibitors of Trypanosoma cruzi with novel mechanisms of action are urgently required to diversify the current clinical and preclinical pipelines. Increasing the number and diversity of hits available for assessment at the beginning of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de70cd8bb075d45ff1f1bb4e212c14b
https://doi.org/10.4155/fmc.13.139
https://doi.org/10.4155/fmc.13.139
Autor:
Tanya Armstrong, Thomas W. von Geldern, Sen Z. Wang, Bradley Berven, Michael J. Abbott, Ivan Scandale, Susan A. Charman, Jason H. Chaplin, Andrea Khong, Joshua D. McManus, Eric Chatelain, Adriana Botero, Wayne M. Best, Julia Morizzi, Maria Kerfoot, Tien Nguyen, Paul W. Alexander, Karen L. White, R.C. Andrew Thompson, Martine Keenan, Eileen Ryan
Publikováno v:
Journal of Medicinal Chemistry. 55:4189-4204
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi ( T. cruzi ), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC(50)s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a30d423509261689188e5175fe646b
https://doi.org/10.1021/jm2015809
https://doi.org/10.1021/jm2015809