Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thomas W. Seng"'
Autor:
J.L. Oskins, Bryan H. Norman, Mark Chambers, Norman Earle Hughes, Stefan Jon Thibodeaux, Matthew Allen Schiffler, Matthew J. Fisher, Thomas W. Seng, Xiao-Peng Yu, C. Lin, Srinivasan Chandrasekhar, Anita K. Harvey
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:635-644
Prostaglandin (PG) E2 plays a critical role in eliciting inflammation. Nonsteroidal anti-inflammatory drugs and selective inhibitors of cyclooxygenase, which block PGE2 production, have been used as key agents in treating inflammation and pain associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61706c85be6f948a476e83f92edb49d2
https://doi.org/10.1124/jpet.115.228932
https://doi.org/10.1124/jpet.115.228932
Autor:
Srinivasan Chandrasekhar, Bradley Condon, Matthew Allen Schiffler, Kuklish Steven Lee, Kim Euibong Jemes, Bryan H. Norman, John R. Rizzo, Jeremy Schulenburg York, Kristina M. Campanale, Stefan Jon Thibodeaux, Richard E. Rathmell, Michael J. Hickey, Christopher Groshong, Shobha N. Bhattachar, Norman Earle Hughes, Anita K. Harvey, John G. Luz, Stephen Antonysamy, Scott Alan Jones, Timothy Andrew Woods, Prashant V. Desai, Matthew J. Fisher, Xiao-Peng Yu, Thomas W. Seng
Publikováno v:
Journal of Medicinal Chemistry. 59:194-205
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa147abbccd68e15b02f28a0c1735a
https://doi.org/10.1021/acs.jmedchem.5b01249
https://doi.org/10.1021/acs.jmedchem.5b01249
Autor:
Joseph T. Brozinick, William Glen Holloway, Vincent L. Reynolds, Lisa A. Adams, David A Yurek, Jason Eric Lamar, Thomas B. Estridge, Thomas W. Seng, Isabel C. Gonzalez Valcarcel, Jennifer M. Weller, Marian Mosior, Eric D. Hawkins, Michael James Genin, Jeffrey Weidner
Publikováno v:
Journal of medicinal chemistry. 59(12)
To develop novel treatments for type 2 diabetes and dyslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT). To this end compounds 1 and 2 were developed as potent SPT inhibitors in vitro. 1 and 2 reduce plasma ceramides in rodents,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c4279b6534d23981c2bcbd145b84c5
https://pubmed.ncbi.nlm.nih.gov/27213958
https://pubmed.ncbi.nlm.nih.gov/27213958
Autor:
Joanne S. Kays, Craig D. Hammond, Thomas W. Seng, Tiffanie R. Skillman, Lorri Burris, Nengyu Yang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:127-133
Carnitine palmitoyltransferase 1beta (CPT-1beta) is a key regulator of the beta oxidation of long-chain fatty acids in skeletal muscle and therefore a potential therapeutic target for diseases associated with defects in lipid metabolism such as obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c686d2d2f28ce33f3054d1239d3de0ea
https://doi.org/10.1124/jpet.104.074104
https://doi.org/10.1124/jpet.104.074104
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3237-3242
Acetyl CoA carboxylase (ACC) catalyzes the carboxylation of acetyl CoA to form malonyl CoA. In skeletal muscle and heart, malonyl CoA functions to regulate lipid oxidation by inhibition of carnitine palmitoyltransferase-1, an enzyme which controls th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee1db61abe84a8d50a9d450451575cb
https://doi.org/10.1016/s0960-894x(03)00664-4
https://doi.org/10.1016/s0960-894x(03)00664-4
Autor:
Craig D. Hammond, Michael A. Statnick, Jose F. Caro, Eric Ravussin, Thomas W. Seng, Robert Alan Gadski, Lisa Selsam Beavers, Todd M. Suter, Helena Corominola, Ronit Rafaeloff-Phail, James P. Sluka, Dwayne Johnson, Laura J. Conner
Publikováno v:
International journal of experimental diabetes research
We have screened a subtracted cDNA library in order to identify differentially expressed genes in omental adipose tissue of human patients with Type 2 diabetes. One clone (#1738) showed a marked reduction in omental adipose tissue from patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a66d52e6af8f8b220e10b88c1a95f7c
https://doi.org/10.1155/edr.2000.81
https://doi.org/10.1155/edr.2000.81
Autor:
Thomas W. Seng, David J. Hall, Griffith D. Parks, Ann C. Palmenberg, Richard H. Ingraham, Peter V. Pallai
Publikováno v:
Virology. 190:754-762
The primary 2A/2B cleavage within cardiovirus polyprotein was examined by construction of cDNA plasmids which linked fragments from the P2 region of encephalomyocarditis virus (EMCV) and Mengovirus genomes to the EMCV 5' nontranslated region. When RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706f627709a66523c249caf6fd790004
https://doi.org/10.1016/0042-6822(92)90913-a
https://doi.org/10.1016/0042-6822(92)90913-a