An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer

Autor: Thomas W. Rees, Ruilin Guan, Xinxing Liao, Hui Chao, Liang-Nian Ji, Lina Xie, Kai Xiong, Li-Li Wang, Yu Chen

Publikováno v: Angewandte Chemie International Edition. 60:4657-4665

Immunogenic cell death (ICD) is a vital component of therapeutically induced anti-tumor immunity. An iridium(III) complex (Ir1), containing an N,N-bis(2-chloroethyl)-azane derivate, as an endoplasmic reticulum-localized ICD inducer for non-small cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b471e40bfbf6a1fbc7ffc99929dc32
https://doi.org/10.1002/anie.202013987

A Mitochondrion‐Localized Two‐Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors

Autor: Thomas W. Rees, Yu Chen, Shi Kuang, Liang-Nian Ji, Xiting Zhang, Leli Zeng, Lingli Sun, Xianrui Zhang, Xinxing Liao, Hui Chao

Publikováno v: Angewandte Chemie International Edition. 59:20697-20703

The efficacy of photodynamic therapy is typically reliant on the local concentration and diffusion of oxygen. Due to the hypoxic microenvironment found in solid tumors, oxygen-independent photosensitizers are in great demand for cancer therapy. We he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b325c51e7c9ed998ed786848986b7e20
https://doi.org/10.1002/anie.202009888

Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

Autor: Liting He, Jian Wan, Hui Chao, Thomas W. Rees, Yi-Xian Yuan, Liang-Nian Ji, Chen Qian, Lin Wei, Yu Chen, Kai Xiong, Xinxing Liao

Publikováno v: Angewandte Chemie International Edition. 59:16631-16637

Inducing necroptosis in cancer cells is an effective approach to circumvent drug-resistance. Metal-based triggers have, however, rarely been reported. Ruthenium(II) complexes containing 1,1-(pyrazin-2-yl)pyreno[4,5-e][1,2,4]triazine were developed wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b91aae1e2de953baae14e56a0739741
https://doi.org/10.1002/anie.202006089

Rational Design of Cyclometalated Iridium(III) Complexes for Three‐Photon Phosphorescence Bioimaging

Autor: Yong Shen, Fengyin Liang, Jinquan Wang, Zhong Pei, Li-Li Wang, Hui Chao, Jiangping Liu, Thomas W. Rees, Bo Yuan, Chengzhi Jin, Liang-Nian Ji, Hui Wang, Xinxing Liao

Publikováno v: Angewandte Chemie International Edition. 59:15987-15991

Compared to 2PE (two-photon excitation) microscopy, 3PE microscopy has superior spatial resolution, deeper tissue penetration, and less defocused interference. The design of suitable agents with a large Stokes shift, good three-photon absorption (3PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8f130fcb1f281d343ba33c198606e5
https://doi.org/10.1002/anie.202006964

Numerical and experimental studies of the hypersonic flow around a cube at incidence

Autor: Jim A. Merrifield, Thomas W. Rees, Tom B. Fisher, Mark K. Quinn, Paul J. K. Bruce

Publikováno v: Rees, T W, Bruce, P J K, Fisher, T B, Quinn, M K & Merrifield, J A 2021, ' Numerical and experimental studies of the hypersonic flow around a cube at incidence ', Acta Astronautica, vol. 183, pp. 75-88 . https://doi.org/10.1016/j.actaastro.2021.02.033

In order to improve predictions of the on-ground casualty risk associated with the uncontrolled atmospheric re-entry of satellites from Low Earth Orbit, there is significant research interest in the development of engineering models of hypersonic hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943aaac345c3e973852ccfe6c7d32b80
https://doi.org/10.1016/j.actaastro.2021.02.033