Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Autor: Maura Marcucci, Thomas W. Painter, David Conen, Kate Leslie, Vladimir V. Lomivorotov, Daniel Sessler, Matthew T. V. Chan, Flavia K. Borges, Maria J. Martínez Zapata, C. Y. Wang, Denis Xavier, Sandra N. Ofori, Giovanni Landoni, Sergey Efremov, Ydo V. Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Maria Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Emmanuelle Duceppe, Kurtz Ruetzler, Joel L. Parlow, Vikas Tandon, Michael K. Wang, Edith Fleischmann, Carisi A. Polanczyk, Raja Jayaram, Sergey V. Astrakov, Mangala Rao, Tomas VanHelder, William K. K. Wu, Chao Chia Cheong, Sabry Ayad, Marat Abubakirov, Mikhail Kirov, Keyur Bhatt, Miriam de Nadal, Valery Likhvantsev, Pilar Paniagua Iglesisas, Hector J. Aguado, Michael McGillion, Andre Lamy, Richard P. Whitlock, Pavel Roshanov, David Stillo, Ingrid Copland, Jessica Vincent, Kumar Balasubramanian, Shrikant I. Bangdiwala, Bruce Biccard, Andrea Kurz, Sadeesh Srinathan, Shirley Petit, John Eikelboom, Toby Richards, Peter L. Gross, Pascal Alfonsi, Gordon Guyatt, Emily Belley-Cote, Jessica Spence, William McIntyre, Salim Yusuf, P. J. Devereaux

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-12 (2022)

Abstract Background For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to r

Externí odkaz: https://doaj.org/article/ac890204cd84433d8ed555ab388c2508

Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Autor: C David, Mazer, Richard P, Whitlock, Dean A, Fergusson, Judith, Hall, Emilie, Belley-Cote, Katherine, Connolly, Boris, Khanykin, Alexander J, Gregory, Étienne, de Médicis, Shay, McGuinness, Alistair, Royse, François M, Carrier, Paul J, Young, Juan C, Villar, Hilary P, Grocott, Manfred D, Seeberger, Stephen, Fremes, François, Lellouche, Summer, Syed, Kelly, Byrne, Sean M, Bagshaw, Nian C, Hwang, Chirag, Mehta, Thomas W, Painter, Colin, Royse, Subodh, Verma, Gregory M T, Hare, Ashley, Cohen, Kevin E, Thorpe, Peter, Jüni, Nadine, Shehata, A, Deschamps

Publikováno v: Mazer, C David; Whitlock, Richard P; Fergusson, Dean A; Hall, Judith; Belley-Cote, Emilie; Connolly, Katherine; Khanykin, Boris; Gregory, Alexander J; de Médicis, Étienne; McGuinness, Shay; Royse, Alistair; Carrier, François M; Young, Paul J; Villar, Juan C; Grocott, Hilary P; Seeberger, Manfred D; Fremes, Stephen; Lellouche, François; Syed, Summer; Byrne, Kelly; ... (2017). Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery. New England journal of medicine NEJM, 377(22), pp. 2133-2144. Massachusetts Medical Society MMS 10.1056/NEJMoa1711818

BACKGROUND The effect of a restrictive versus liberal red-cell transfusion strategy on clinical outcomes in patients undergoing cardiac surgery remains unclear. METHODS In this multicenter, open-label, noninferiority trial, we randomly assigned 5243

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3190bf397c49e2356538e7914c9ab26
https://boris.unibe.ch/107736/

Reducing system errors in the preoperative assessment process

Autor: Thomas W. Painter

Publikováno v: BJA: British Journal of Anaesthesia. 111

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b839111f190a9e864ea305d7b16a48b
https://doi.org/10.1093/bja/el_9794