Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Thomas W. North"'
Autor:
Jesse D Deere, Robert C Kauffman, Elda Cannavo, Joanne Higgins, Andradi Villalobos, Lourdes Adamson, Raymond F Schinazi, Paul A Luciw, Thomas W North
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87914 (2014)
Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated. The mechanisms of viral persistence during HAART are poorly
Externí odkaz:
https://doaj.org/article/6a5dec7323064294b4d342186b278c9a
Autor:
Debra A Wadford, Robert C Kauffman, Jesse D Deere, Scott T Aoki, Richard A Stanton, Joanne Higgins, Koen K A Van Rompay, Andradi Villalobos, James H Nettles, Raymond F Schinazi, Niels C Pedersen, Thomas W North
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86997 (2014)
RT-SHIV is a chimera of simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT)-encoding region of human immunodeficiency virus type 1 (HIV-1) within the backbone of SIVmac239. It has been used in a non-human primate model for s
Externí odkaz:
https://doaj.org/article/5f1423224fd94d54b2ae48fbe6d694ee
Autor:
Jesse D Deere, Joanne Higgins, Elda Cannavo, Andradi Villalobos, Lourdes Adamson, Emilie Fromentin, Raymond F Schinazi, Paul A Luciw, Thomas W North
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11640 (2010)
To prevent progression to AIDS, persons infected with human immunodeficiency virus type 1 (HIV-1) must remain on highly active antiretroviral therapy (HAART) indefinitely since this modality does not eradicate the virus. The mechanisms involved in vi
Externí odkaz:
https://doaj.org/article/a2eec88abdca4b5fb5fd4613777254fa
Autor:
Mervi Detorio, Thomas W. North, Selwyn J. Hurwitz, Christina Gavegnano, Leda Bassit, Raymond F. Schinazi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:1262-1269
Understanding the cellular pharmacology of antiretroviral agents in macrophages and subsequent correlation with antiviral potency provides a sentinel foundation for definition of the dynamics between antiretroviral agents and viral reservoirs across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca3b8f814703116a3c00bc99bc7ab17
https://doi.org/10.1128/aac.02012-12
https://doi.org/10.1128/aac.02012-12
Autor:
Jacquelyn Gervay-Hague, Yen T. Duong, Indresh K. Srivastava, D. Christopher Meadows, Thomas W. North
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:1780-1786
With more than 40 million people living with human immunodeficiency virus (HIV), there is an urgent need to develop drugs that can be used in the form of a topical microbicide to prevent infection through sexual transmission. DCM205 is a recently dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f102cee2557d3d4d972218744d724581
https://doi.org/10.1128/aac.01001-06
https://doi.org/10.1128/aac.01001-06
Autor:
Thomas W. North, Jacquelyn Gervay-Hague, Tino W. Sanchez, D. Christopher Meadows, Nouri Neamati
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1127-1137
In a previous study, we prepared a small library of chicoric acid analogs that possessed both potent anti-integrase and antiviral activity. It was also shown that active compounds fell into one of two groups: those that inhibited an early stage in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db4af13e89c9a39a398c1919a18bae
https://doi.org/10.1016/j.bmc.2006.10.017
https://doi.org/10.1016/j.bmc.2006.10.017
Autor:
Niels C Pedersen, Timothy B. Matthews, Raymond F. Schinazi, Thomas W. North, Debra A. Wadford, Koen K. A. Van Rompay, Joanne Higgins
Publikováno v:
Journal of Virology. 79:7349-7354
We have modeled highly active antiretroviral therapy (HAART) for AIDS in rhesus macaques infected with a chimera (RT-SHIV) of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type-1 (HIV-1). Seven RT-SH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f957be942dd3f27e5d4e22da7c144a2d
https://doi.org/10.1128/jvi.79.12.7349-7354.2005
https://doi.org/10.1128/jvi.79.12.7349-7354.2005
Autor:
Chris Reading, Richard Rigg, Niels C Pedersen, Thomas W. North, Gary L. Henderson, Joanne Higgins, Christian M. Leutenegger
Publikováno v:
Veterinary Immunology and Immunopathology. 94:133-148
16alpha-Bromo-epiandrosterone (epiBr), a synthetic derivative of the natural hormone dehyroepiandrosterone (DHEA), was evaluated for its effects on feline immunodeficiency virus (FIV) infection in experimental cats. The rationale for this study was b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e58acae55fbff78314e094dcf28232
https://doi.org/10.1016/s0165-2427(03)00081-3
https://doi.org/10.1016/s0165-2427(03)00081-3
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:1756-1759
We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbee07f7c4c3efbcba94d674b741255
https://doi.org/10.1128/aac.47.5.1756-1759.2003
https://doi.org/10.1128/aac.47.5.1756-1759.2003
Publikováno v:
Journal of Biological Chemistry. 278:7902-7909
Many retroviruses either encode dUTP pyrophosphatase (dUTPase) or package host-derived uracil DNA glycosylase as a means to limit the accumulation of uracil in DNA strands, suggesting that uracil is detrimental to one or more steps in the viral life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbae4597c5867dac0c3a2f194762f01e
https://doi.org/10.1074/jbc.m207223200
https://doi.org/10.1074/jbc.m207223200