Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas W. M. Crozier"'
Autor:
Jarrod Shilts, Thomas W. M. Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J. D. Greenwood, Samuel James Watson, Brian M. Ortmann, Christian M. Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A. Nathan, Stefan Pöhlmann, Nicholas J. Matheson, Paul J. Lehner, Gavin J. Wright
Publikováno v:
PLoS Biology, Vol 21, Iss 2 (2023)
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein is the largest structural compon
Externí odkaz:
https://doaj.org/article/90f98ee96aff4b489c474fa416cf8b43
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early stud
Externí odkaz:
https://doaj.org/article/985b50f6b24543619791a2c52c0f7f97
Autor:
Michele Tinti, Maria Lucia S. Güther, Thomas W. M. Crozier, Angus I. Lamond, Michael A. J. Ferguson
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Cellular proteins vary significantly in both abundance and turnover rates. These parameters depend upon their rates of synthesis and degradation and it is useful to have access to data on protein turnover rates when, for example, designin
Externí odkaz:
https://doaj.org/article/b1716ed1b9624d2eb356fb14dd688c86
Autor:
Teresa, Brevini, Mailis, Maes, Gwilym J, Webb, Binu V, John, Claudia D, Fuchs, Gustav, Buescher, Lu, Wang, Chelsea, Griffiths, Marnie L, Brown, William E, Scott, Pehuén, Pereyra-Gerber, William T H, Gelson, Stephanie, Brown, Scott, Dillon, Daniele, Muraro, Jo, Sharp, Megan, Neary, Helen, Box, Lee, Tatham, James, Stewart, Paul, Curley, Henry, Pertinez, Sally, Forrest, Petra, Mlcochova, Sagar S, Varankar, Mahnaz, Darvish-Damavandi, Victoria L, Mulcahy, Rhoda E, Kuc, Thomas L, Williams, James A, Heslop, Davide, Rossetti, Olivia C, Tysoe, Vasileios, Galanakis, Marta, Vila-Gonzalez, Thomas W M, Crozier, Johannes, Bargehr, Sanjay, Sinha, Sara S, Upponi, Corrina, Fear, Lisa, Swift, Kourosh, Saeb-Parsy, Susan E, Davies, Axel, Wester, Hannes, Hagström, Espen, Melum, Darran, Clements, Peter, Humphreys, Jo, Herriott, Edyta, Kijak, Helen, Cox, Chloe, Bramwell, Anthony, Valentijn, Christopher J R, Illingworth, Bassam, Dahman, Dustin R, Bastaich, Raphaella D, Ferreira, Thomas, Marjot, Eleanor, Barnes, Andrew M, Moon, Alfred S, Barritt, Ravindra K, Gupta, Stephen, Baker, Anthony P, Davenport, Gareth, Corbett, Vassilis G, Gorgoulis, Simon J A, Buczacki, Joo-Hyeon, Lee, Nicholas J, Matheson, Michael, Trauner, Andrew J, Fisher, Paul, Gibbs, Andrew J, Butler, Christopher J E, Watson, George F, Mells, Gordon, Dougan, Andrew, Owen, Ansgar W, Lohse, Ludovic, Vallier, Fotios, Sampaziotis
Publikováno v:
Nature. 615:134-142
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms that control t
Autor:
Stefan Pöhlmann, Samuel James Watson, Markus Hoffmann, Edward J. D. Greenwood, Thomas W M Crozier, Paul J. Lehner, Gavin J. Wright, Tekle Pauzaite, Christian M. Gawden-Bone, James A. Nathan, Brian Ortmann, Jarrod Shilts, Ildar Gabaev, Ana Teixeira-Silva
SummaryThe interactions between severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to COVID-19. The spike protein is the largest structural component of the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c745d2a09185fb2899e2caf0a429112f
https://doi.org/10.1101/2021.09.25.461776
https://doi.org/10.1101/2021.09.25.461776
Autor:
Edward J. D. Greenwood, Brian Ortmann, Paul J. Lehner, James A. Nathan, Frank McCaughan, Daniel Kottmann, Ravindra Mahadeva, Wenrui Guo, Linsey Porter, Thomas W M Crozier
Cigarette smoking has multiple serious negative health consequences. However, the epidemiological relationship between cigarette smoking and SARS-CoV-2 infection is controversial; and the interaction between cigarette smoking, airway expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f816399bcd216e9969ce18445f8342
https://doi.org/10.1101/2021.09.08.459428
https://doi.org/10.1101/2021.09.08.459428
Autor:
Olivia C. Tysoe, Andrew M. Moon, Paul Gibbs, Sally Forrest, Sanjay Sinha, Johannes Bargehr, Daniele Muraro, Sidney A Barritt, William Gelson, Gwilym J. Webb, Eleanor Barnes, Mailis Maes, Stephen Baker, Gareth Corbett, Thomas L Williams, Gordon Dougan, Vasileios Galanakis, Ravindra K. Gupta, Fotios Sampaziotis, Scott Dillon, Ludovic Vallier, Lisa Swift, Teresa Brevini, Andrew J. Butler, Mahnaz Darvish-Damavandi, Sara Upponi, Ansgar W. Lohse, George F. Mells, Kourosh Saeb-Parsy, Simon J.A. Buczacki, Marta Vila-Gonzalez, Victoria L. Mulcahy, Susan E. Davies, Sagar Varankar, Thomas Marjot, Petra Mlcochova, Christopher J.E. Watson, Anthony P. Davenport, Joo-Hyeon Lee, Thomas W M Crozier, Rhoda E. Kuc
Prevention of SARS-CoV-2 entry in cells through the modulation of viral host receptors, such as ACE2, could represent a new therapeutic approach complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive. Here, we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67bbf5a5471abdb9a98cd836cdc4ceac
https://doi.org/10.1101/2021.06.06.446781
https://doi.org/10.1101/2021.06.06.446781
Autor:
Fabio T. M. Costa, Paul J. Lehner, Sam J. Wilson, Suzannah J. Rihn, David Robertson, Srikeerthana Kuchi, Quan Gu, Thomas W M Crozier, Alfredo Castello-Palomares, Rute Maria Pinto, Elena Sugrue, Matthew L. Turnbull, Isaric C-Investigators, Colin Loney, Monique Freire Santana, Jay Allan, Luiz Carlos de Lima Ferreira, Spyros Lytras, Antonia Ho, Natalia Cameron-Ruiz, Richard J. Stanton, Ruth F. Jarrett, Vanessa Herder, Arthur Wickenhagen, Innes Jarmson, Bo Wang, Sara Clohisey, Edward Chung Yern Wang, Matthias Marti, Massimo Palmarini, Kenneth Baillie, Marko Noerenberg, Joao Luiz Da Silva Filho, Douglas G. Stewart, Margus Varjak, Edward J. D. Greenwood, Simon Swingler
Cell autonomous antiviral defenses can inhibit the replication of viruses and reduce transmission and disease severity. To better understand the antiviral response to SARS-CoV-2, we used interferon-stimulated gene (ISG) expression screening to reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd517e51ccb503d025f6bea1c5a2cbb
https://doi.org/10.1101/2021.05.05.21256681
https://doi.org/10.1101/2021.05.05.21256681
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6a0b2837f326dd8f886a2d928229aa
Publikováno v:
Cell Reports
Summary Kaposi’s sarcoma herpesvirus (KSHV) is an oncogenic human virus and the leading cause of mortality in HIV infection. KSHV reactivation from latent- to lytic-stage infection initiates a cascade of viral gene expression. Here we show how thes