Výsledky vyhledávání - "Thomas W. Leonard"

Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET®)

Autor: Sam Maher, Thomas W. Leonard, John S Fox, Edel O'toole, Kishore Babu Chalasani, David J. Brayden, Edwin G. Walsh, Bozena Adamczyk

Publikováno v: Therapeutic Delivery. 2:1595-1610

Oral delivery of macromolecular drugs, particularly peptides and proteins, is the focus of many academic and industrial laboratories. Armed with an increased understanding of the structure and regulation of intestinal epithelial junctional complexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2858434c2131dbf86804bca3d1305d
https://doi.org/10.4155/tde.11.132

Zobrazit plný text záznamu

Oral administration of the GnRH antagonist acyline, in a GIPET®-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics

Autor: William J. Bremner, Edel O'toole, Michael J. McKenna, Thomas W. Leonard, John K. Amory, Stephanie T. Page

Publikováno v: Cancer Chemotherapy and Pharmacology. 64:641-645

GnRH analogs are useful for the treatment of prostate cancer, but require parenteral administration. The peptide GnRH antagonist acyline potently suppresses luteinizing hormone (LH) and testosterone in man; however, its clinical utility is limited by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf4e18ffbab116931b127209ba7433a
https://doi.org/10.1007/s00280-009-1038-1

Zobrazit plný text záznamu

Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™

Autor: Michael J. McKenna, David J. Brayden, Thomas W. Leonard, John Lynch

Publikováno v: Expert Opinion on Drug Delivery. 3:685-692

One of the most important and challenging goals in drug delivery is overcoming the poor oral absorption of high-value therapeutics that include peptides. Gastrointestinal Permeation Enhancement Technology (GIPET) attempts to address this question by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b969ff7b03daff356f164c44215c08
https://doi.org/10.1517/17425247.3.5.685

Zobrazit plný text záznamu

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic

Autor: Thomas W. Leonard, David J. Brayden, Sam Maher, Jette Bredahl Jacobsen

Publikováno v: Advanced drug delivery reviews. 61(15)

A major challenge in oral drug delivery is the development of novel dosage forms to promote absorption of poorly permeable Class III drugs across the intestinal epithelium. To date, no absorption promoter has been approved in a formulation specifical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d394af329aabab3e3ec84114d5ac132
https://pubmed.ncbi.nlm.nih.gov/19800376

Zobrazit plný text záznamu

Relief of hot flushes with new plant-derived 10-component synthetic conjugated estrogens

Autor: Brenda M. Williams, Samuel A. Lederman, Rhonda Y. Vega, Wulf H. Utian, Thomas W. Leonard, William D. Koltun

Publikováno v: Obstetrics and gynecology. 103(2)

OBJECTIVE: A study was conducted to evaluate the safety and efficacy of 3 different doses of synthetic conjugated estrogens B, a new plant-derived 10-component conjugated estrogens product, for the treatment of menopausal vasomotor symptoms. METHODS:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fc2a7c59b5effd3666d89a5dbd6ed6
https://pubmed.ncbi.nlm.nih.gov/14754691

Zobrazit plný text záznamu

Abstract B57: Safety profile of zoledronic acid in a novel oral formulation

Autor: Angela Walsh, Thomas W. Leonard, Kieran Madigan, Catherine McHugh, John S Fox

Publikováno v: Molecular Cancer Therapeutics. 8:B57-B57

Background: Orazol™(MER-101) tablets utilize GIPET® to formulate an oral alternative to intravenous zoledronic acid (ZA) IV (Zometa®). Orazol's enteric coating and high bioavailability decreases GI exposure and provides a tablet with an excellent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eee3907f60f558ceccac87229cb07400
https://doi.org/10.1158/1535-7163.targ-09-b57

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání