Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas W. Hudyma"'
Autor:
Robert G. Gentles, Piyasena Hewawasam, Yong Tu, Thomas W. Hudyma, Nicholas A. Meanwell, John F. Kadow, Xiaofan Zhang
Publikováno v:
Tetrahedron Letters. 55:1148-1153
A convenient and practical synthesis of 6-carboalkoxy-13-cycloalkyl-5 H -indolo[2,1- a ][2]benzazepine-10-carboxylic acid derivatives ( 6 ) has been developed. The key step in the synthesis utilizes an intramolecular tandem reaction sequence of a Mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a1aa68f0423ecc0ed990dcc538fe1f3
https://doi.org/10.1016/j.tetlet.2013.12.085
https://doi.org/10.1016/j.tetlet.2013.12.085
Autor:
Zhong Yang, Jay O. Knipe, Susan B. Roberts, Yong Tu, Paul E. Morin, Ying-Kai Wang, John Wan, Andrew Nickel, Katharine A. Grant-Young, Piyasena Hewawasam, Sam T. Chao, Xiaoliang Zhuo, Bergstrom Carl P, Brett R. Beno, Qi Gao, Dianlin Xie, Chong-Hwan Chang, Dawn D. Parker, Mian Gao, Alicia Regueiro-Ren, Mengping Liu, Umesh Hanumegowda, Richard J. Colonno, Kathy Mosure, Nicholas A. Meanwell, Min Ding, Lenore A. Pelosi, John F. Kadow, Xiaofan Zheng, Steven Sheriff, Voss Stacey A, Alicia Ng, Kenneth S. Santone, Mark R. Witmer, Jung-Hui Sun, Robert G. Gentles, Bender John A, Min Gao, Yi Wang, Jeff Tredup, Daniel M. Camac, Scott W. Martin, Thomas W. Hudyma, Julie A. Lemm, Kap-Sun Yeung, Karen Rigat
Publikováno v:
Journal of Medicinal Chemistry. 57:1855-1879
Described herein are structure-activity relationship studies that resulted in the optimization of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors. Subsequent iterations of analogue design and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef74807d123b8140c1724c36314db30
https://doi.org/10.1021/jm4016894
https://doi.org/10.1021/jm4016894
Autor:
Brett R. Beno, Thomas W. Hudyma, Karen Rigat, Jay O. Knipe, Susan B. Roberts, Lenore A. Pelosi, Robert A. Fridell, Feng He, Ying-Kai Wang, Xiaofan Zheng, Min Gao, Dike Qiu, John F. Kadow, Min Ding, Michael A. Poss, Mengping Liu, Voss Stacey A, Julie A. Lemm, Robert G. Gentles
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2866-2871
Presented here are initial structure-activity relationship (SAR) studies on a series of novel heteroaryl fused tetracyclic indole-based inhibitors of the hepatitis C viral polymerase, NS5B. The introduction of alternative heterocyclic moieties into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5d113bcef564f4c0c7aff6616ae9a3
https://doi.org/10.1016/j.bmcl.2012.02.063
https://doi.org/10.1016/j.bmcl.2012.02.063
Autor:
Oak K. Kim, John D. Matiskella, B. Narasimhulu Naidu, Yasutsugu Ueda, Thomas W. Hudyma, Xiaofan Zheng, Alicia Regueiro-Ren, Margaret E. Sorenson, Joanne J. Bronson, Yunhui Zhang, Junius M. Clark, Timothy P. Connolly, Michael J. Pucci
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:171-175
Several semi-synthetic bis- and mono- O -alkyl nocathiacin derivatives were synthesized and evaluated for antibacterial activity. Mono- O -alkyl N -hydroxyindole analogues 3a – l were prepared by regioselective alkylation. Bis- O -alkyl nocathiacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb563a9c502bfb899ce991c6ecd46b9f
https://doi.org/10.1016/j.bmcl.2003.09.061
https://doi.org/10.1016/j.bmcl.2003.09.061
Autor:
Kathy Mosure, Ming Zheng, Ravi Tejwani, Junius M. Clark, Yasutsugu Ueda, Timothy P. Connolly, Jerzy Golik, Shin-Hong Kang, Stella Huang, Ivette Medin, Joanne J. Bronson, Jay O. Knipe, Srini Venkatesh, Thomas W. Hudyma, Marina Mathew, Dali Mandar, Lucinda Lamb, John D. Matiskella, Chung-Pin Chen, Qi Gao, Varia Sailesh Amilal, Nancy P. Barbour
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3669-3672
Synthesis of phosphonooxymethyl derivatives of ravuconazole, 2 (BMS-379224) and 3 (BMS-315801) and their biological evaluation as potential water-soluble prodrugs of ravuconazole are described. The phosphonooxymethyl ether analogue 2 (BMS-379224) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4e0239c057c8cbd2affa473fecf35c
https://doi.org/10.1016/j.bmcl.2003.08.029
https://doi.org/10.1016/j.bmcl.2003.08.029
Autor:
Xiaofan Zhang, Robert G. Gentles, John F. Kadow, Nicholas A. Meanwell, Yong Tu, Thomas W. Hudyma, Piyasena Hewawasam
Publikováno v:
ChemInform. 45
A convenient and practical synthesis of 6-carboalkoxy-13-cycloalkyl-5 H -indolo[2,1- a ][2]benzazepine-10-carboxylic acid derivatives ( 6 ) has been developed. The key step in the synthesis utilizes an intramolecular tandem reaction sequence of a Mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a274a526fe9c0a20fa9283cbc4ea14
https://doi.org/10.1002/chin.201428182
https://doi.org/10.1002/chin.201428182
Autor:
John A. Wichtowski, Yuan Tsai, Ken Denbleyker, Peter F. Misco, Jollie D. Godfrey, Janak Singh, Raymond F. Miller, Junius M. Clark, John D. Matiskella, Michael J. Pucci, Richard H. Mueller, Michael J. Humora, Boyhan Brenda T, Thomas P. Kissick, Joan Fung-Tomc, Stan V. D'Andrea, David R. Kronenthal, Robert K. Perrone, Yasutsuga Ueda, Annie Pullockaran, Murray A. Kaplan, Sterzycki Roman Z, James E. Heikes, Shelley E. Hoeft, Fritz Alan W, Truc Chi Vu, Rita Fox, Joanne J. Bronson, Jeffery T. North, D P Bonner, Thomas W. Hudyma
Publikováno v:
Tetrahedron. 56:5687-5698
Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625ad66e9507d6b330714a80db975bfd
https://doi.org/10.1016/s0040-4020(00)00418-x
https://doi.org/10.1016/s0040-4020(00)00418-x
Autor:
Joanne J. Bronson, Oak K. Kim, Thomas W. Hudyma, John D. Matiskella, Yasutsugu Ueda, Muzammil M. Mansuri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2753-2758
A series of cephalosporins bearing C-3 quaternary ammonium groups were prepared and evaluated for their anti-MRSA activity. They exhibit good to excellent in vitro activity (MICs = 1−8 μg/mL) against MRSA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4ce7aef58b79a5877b1ad1db273cefb
https://doi.org/10.1016/s0960-894x(97)10078-6
https://doi.org/10.1016/s0960-894x(97)10078-6
Autor:
Robert T. Standridge, John D. Matiskella, W. F. Minor, J. C. Godfrey, P F Juby, Thomas A. Montzka, B A Hall, Richard A. Partyka, Nancy M. Cladel, R B Babel, Thomas W. Hudyma, George M. Luke, Lee C Cheney, G. E. Bocian
Publikováno v:
Journal of medicinal chemistry. 10(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5820dcca4c7292d6fd0ec128763cd2f3
https://pubmed.ncbi.nlm.nih.gov/22185163
https://pubmed.ncbi.nlm.nih.gov/22185163
Autor:
Paul E. Morin, Dike Qiu, Steven Sheriff, Bergstrom Carl P, Michael A. Poss, Feng He, Brett R. Beno, Mark R. Witmer, Min Gao, Mengping Liu, Voss Stacey A, Julie A. Lemm, Lenore A. Pelosi, Robert G. Gentles, Jeffrey L. Romine, Karen Rigat, Scott W. Martin, John F. Kadow, Thomas W. Hudyma, Daniel M. Camac, Chong-Hwan Chang, Ying-Kai Wang, Jay O. Knipe, Susan B. Roberts, John Wan, Robert A. Fridell, Xiaofan Zheng, Min Ding
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Herein, we present initial SAR studies on a series of bridged 2-arylindole-based NS5B inhibitors. The introduction of bridging elements between the indole N1 and the ortho-position of the 2-aryl moiety resulted in conformationally constrained heteroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725aed0eab23e6a4fc53e82946e3d5db
https://pubmed.ncbi.nlm.nih.gov/21486696
https://pubmed.ncbi.nlm.nih.gov/21486696