Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Thomas W. H. Kay"'
Autor:
Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison M. Weppler, Nirupa Sachithanandan, Cherie Chiang, Peter G. Colman, John Wentworth, Lavinia Spain, George Au-Yeung, Belinda Lee, Thomas W. H. Kay, Rodney J. Hicks, Shahneen Sandhu, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionHypophysitis is reported in 8.5%–14% of patients receiving combination immune checkpoint inhibition (cICI) but can be a diagnostic challenge. This study aimed to assess the role of routine diagnostic imaging performed during therapeutic
Externí odkaz:
https://doaj.org/article/fb5d37ec95e142d795c4d6ee92680ea7
Autor:
Balasubramanian Krishnamurthy, Matthew Lacorcia, Thomas W. H. Kay, Helen E. Thomas, Stuart I. Mannering
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease. Short-term treatment with agents targeting T cells, B cells and inflammatory cytokines to modify the disease course resulted in a short-term pause in disease activity. Lessons learnt from
Externí odkaz:
https://doaj.org/article/0e1b8fe12e0848439e27932c9bce2a87
Autor:
David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is challenging to study mechanistically in humans because it is not possible to
Externí odkaz:
https://doaj.org/article/6fda57144c434ff1bfc7c70a1820ea51
Autor:
Anna Galligan, Roslyn Wallace, Balasubramanian Krishnamurthy, Thomas W. H. Kay, Nirupa Sachithanandan, Cherie Chiang, Shahneen Sandhu, Rodney J. Hicks, Amir Iravani
Publikováno v:
Cancers, Vol 15, Iss 24, p 5803 (2023)
Background: FDG-PET/CT used for immune checkpoint inhibitor (ICI) response assessment can incidentally identify immune-related adverse events (irAEs), including thyroiditis. This study aimed to correlate the time course of FDG-PET/CT evidence of thyr
Externí odkaz:
https://doaj.org/article/f232cc202b4d41869107a892b6498a5d
Autor:
Anojian Koneshamoorthy, Dilan Seniveratne-Epa, Genevieve Calder, Matthew Sawyer, Thomas W. H. Kay, Stephen Farrell, Thomas Loudovaris, Lina Mariana, Davis McCarthy, Ruqian Lyu, Xin Liu, Peter Thorn, Jason Tong, Lit Kim Chin, Margaret Zacharin, Alison Trainer, Shelby Taylor, Richard J. MacIsaac, Nirupa Sachithanandan, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
We present a case of an obese 22-year-old man with activating GCK variant who had neonatal hypoglycemia, re-emerging with hypoglycemia later in life. We investigated him for asymptomatic hypoglycemia with a family history of hypoglycemia. Genetic tes
Externí odkaz:
https://doaj.org/article/4a69cf2b5644469b9f635ac9052ea7b7
Autor:
Nicholas A. Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Stuart I. Mannering, Thomas W. H. Kay, Helen E. Thomas
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Diabetogenic T cells infiltrate the pancreatic islets by transmigrating across the microcapillaries residing close to, or within, the pancreatic islets. Deficiency in IFNγ signaling prevents efficient migration of T cells into the pancreatic islets,
Externí odkaz:
https://doaj.org/article/54a3bf8d1510464fbb7af6b7c7abdb27
Autor:
Sara A. Litwak, Jibran A. Wali, Evan G. Pappas, Hamdi Saadi, William J. Stanley, L. Chitra Varanasi, Thomas W. H. Kay, Helen E. Thomas, Esteban N. Gurzov
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
Pancreatic β-cell loss induced by saturated free fatty acids (FFAs) is believed to contribute to type 2 diabetes. Previous studies have shown induction of endoplasmic reticulum (ER) stress, increased ubiquitinated proteins, and deregulation of the B
Externí odkaz:
https://doaj.org/article/cc42862cb1e94bc789cf5a2f5e4bdf7c
Autor:
Rahul D. Barmanray, Joanna Y. Gong, Mervyn Kyi, Dev Kevat, Mohammad A. Islam, Anna Galligan, Georgina R. Manos, Indu V. Nair, Nayomi Perera, Nicholas K. Adams, Ashvin Nursing, Annabelle M. Warren, Peter S. Hamblin, Richard J. MacIsaac, Elif I. Ekinci, Balasubramanian Krishnamurthy, Harin Karunajeewa, Kirsty Buising, Kumar Visvanathan, Thomas W. H. Kay, Spiros Fourlanos
Publikováno v:
Internal Medicine Journal. 53:27-36
Autor:
Rahul D, Barmanray, Joanna Y, Gong, Mervyn, Kyi, Dev, Kevat, Mohammad A, Islam, Anna, Galligan, Georgina R, Manos, Indu V, Nair, Nayomi, Perera, Nicholas K, Adams, Ashvin, Nursing, Annabelle M, Warren, Peter S, Hamblin, Richard J, MacIsaac, Elif I, Ekinci, Balasubramanian, Krishnamurthy, Harin, Karunajeewa, Kirsty, Buising, Kumar, Visvanathan, Thomas W H, Kay, Spiros, Fourlanos
Publikováno v:
Internal medicine journalReferences.
A relationship between diabetes, glucose and COVID-19 outcomes has been reported in international cohorts. This study aimed to assess the relationship between diabetes, hyperglycaemia and patient outcomes in those hospitalised with COVID-19 during th
Autor:
Gaurang, Jhala, Balasubramanian, Krishnamurthy, Thomas C, Brodnicki, Tingting, Ge, Satoru, Akazawa, Claudia, Selck, Prerak M, Trivedi, Evan G, Pappas, Leanne, Mackin, Nicola, Principe, Erwan, Brémaud, David J, De George, Louis, Boon, Ian, Smyth, Jonathan, Chee, Thomas W H, Kay, Helen E, Thomas
Publikováno v:
Cell reports. 39(4)
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese diabetic (NOD) mi