Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Thomas W. Gettys"'
Autor:
Henry A. Palfrey, Avinash Kumar, Rashmi Pathak, Kirsten P. Stone, Thomas W. Gettys, Subramanyam N. Murthy
Publikováno v:
Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Cardiovascular disease (CVD) affects millions worldwide and is the leading cause of death among non-communicable diseases. Western diets typically comprise of meat and dairy products, both of which are rich in cholesterol (Cho) an
Externí odkaz:
https://doaj.org/article/e4df16189bc64281ae5864b37e856425
Autor:
Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s pro
Externí odkaz:
https://doaj.org/article/47e11d4a223a47389d7444778bbfe088
Autor:
Avinash Kumar, Rashmi Pathak, Henry A. Palfrey, Kirsten P. Stone, Thomas W. Gettys, Subramanyam N. Murthy
Publikováno v:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Both cholesterol (Cho) and methionine (Met, a precursor for homocysteine) are risk factors for fatty liver disease. Since Western diets are rich in Cho and Met, we investigated the hepatic effects of feeding a diet enriched in Met
Externí odkaz:
https://doaj.org/article/55d771faa9c64738950ed1a7ef246901
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
FGF21 is a potent metabolic regulator of energy balance, body composition, lipid metabolism, and glucose homeostasis. Initial studies reported that it was increased by fasting and the associated increase in ketones, but more recent work points to the
Externí odkaz:
https://doaj.org/article/b4b1dab8185642aa86d153dd13313a7e
Autor:
Han Fang, Kirsten P. Stone, Laura A. Forney, Landon C. Sims, Gabriela C. Gutierrez, Sujoy Ghosh, Thomas W. Gettys
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102470- (2021)
Summary: Dietary methionine restriction (MR) is normally implemented using diets formulated from elemental amino acids (AA) that reduce methionine content to ∼0.17%. However, translational implementation of MR with elemental AA-based diets is intra
Externí odkaz:
https://doaj.org/article/a743b170ec9c4738875871336e1fbec9
Autor:
Avinash Kumar, Henry A. Palfrey, Rashmi Pathak, Philip J. Kadowitz, Thomas W. Gettys, Subramanyam N. Murthy
Publikováno v:
Nutrition & Metabolism, Vol 14, Iss 1, Pp 1-12 (2017)
Abstract An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown i
Externí odkaz:
https://doaj.org/article/26bdb4043c1047ba9a6cb69a323eb00c
Publikováno v:
Nutrients, Vol 13, Iss 8, p 2609 (2021)
Dietary protein restriction and dietary methionine restriction (MR) produce a comparable series of behavioral, physiological, biochemical, and transcriptional responses. Both dietary regimens produce a similar reduction in intake of sulfur amino acid
Externí odkaz:
https://doaj.org/article/3beb72716b354de28c00e5e937a717fa
Autor:
Han Fang, Kirsten P. Stone, Sujoy Ghosh, Laura A. Forney, Landon C. Sims, LeighAnn Vincik, Thomas W. Gettys
Publikováno v:
Nutrients, Vol 13, Iss 6, p 1788 (2021)
The principal sensing of dietary methionine restriction (MR) occurs in the liver, where it activates multiple transcriptional programs that mediate various biological components of the response. Hepatic Fgf21 is a key target and essential endocrine m
Externí odkaz:
https://doaj.org/article/6397789e3b434fa3b7e9e3e0c5437e1a
Autor:
Thomas Laeger, Diana C. Albarado, Susan J. Burke, Lexus Trosclair, John W. Hedgepeth, Hans-Rudolf Berthoud, Thomas W. Gettys, J. Jason Collier, Heike Münzberg, Christopher D. Morrison
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 707-716 (2016)
FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction. Here, we demonstrate the persistent and essential role of FGF21 in the
Externí odkaz:
https://doaj.org/article/e758a6010e0544be9161b0232b88350a
Publikováno v:
PPAR Research, Vol 2012 (2012)
Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPAR
Externí odkaz:
https://doaj.org/article/33a0316af5b74b63a5a060edf65c3eed