Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Thomas W. Bruice"'
Publikováno v:
FEBS Letters. 509:85-89
We have investigated DNA binding properties of a dicationic polyamide molecule (GL020924) that has exhibited unique protein displacement and gene regulation activities. Fluorescence, thermal melting and electrospray ionization mass spectrometry exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5448f6c9660ab2a44f9d5110d091b00
https://doi.org/10.1016/s0014-5793(01)03085-x
https://doi.org/10.1016/s0014-5793(01)03085-x
Publikováno v:
Journal of the American Chemical Society. 122:5244-5250
A fully automated solid-phase synthetic procedure for incorporation of positively charged guanidinium linkages into otherwise neutral PNA sequences has been employed. These DNG/PNA chimeras form [(DNG/PNA)2·DNA] triplexes upon binding to single stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18a817d9ae3bd1e9c84251a3d604083
https://doi.org/10.1021/ja000022l
https://doi.org/10.1021/ja000022l
Autor:
Thomas W. Bruice, Walt F. Lima
Publikováno v:
Biochemistry. 36:5004-5019
We have explored the use of short (10-mer), fully sequence-randomized oligonucleotide libraries for affinity-based screening in solution for energetically preferred sites of hybridization of a model 47-nucleotide (nt) mutant Ha-ras mRNA stem-loop fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2cc9ca8db6ad662a696a5ad159dd44
https://doi.org/10.1021/bi9620767
https://doi.org/10.1021/bi9620767
Publikováno v:
Journal of Biological Chemistry. 272:626-638
We describe our initial application of a biochemical strategy, comprising combinatorial screening and rational optimization, which directly identifies oligonucleotides with maximum affinity (per unit length), specificity, and rates of hybridization t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbac95637d136946c6ce69570912b463
https://doi.org/10.1074/jbc.272.1.626
https://doi.org/10.1074/jbc.272.1.626
Publikováno v:
Accounts of Chemical Research. 26:98-104
The design of functional molecules has been an active area of research in chemistry and molecular biology during the past decade, encompassing topics such as host-guest chemistry, ribozymes, catalytic antibodies, and most recently, fullerenes. Nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6e191f27fed539622e8dcbde63b8a8
https://doi.org/10.1021/ar00027a004
https://doi.org/10.1021/ar00027a004
Publikováno v:
ChemInform. 24
The design of functional molecules has been an active area of research in chemistry and molecular biology during the past decade, encompassing topics such as host-guest chemistry, ribozymes, catalytic antibodies, and most recently, fullerenes. Nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75db84b99dabcfe97f4322ce68ef6b9
https://doi.org/10.1002/chin.199326275
https://doi.org/10.1002/chin.199326275
Autor:
Nicholas A. Boyle, Vivek K. Rajwanshi, Fu Chen, P. Dan Cook, Jennifer L. Brooks, Marija Prhavc, Tiffany Hurd, Patrick Fagan, Guangyi Wang, Janet M. Leeds, Gregory Ewing, Thomas W. Bruice
Publikováno v:
Journal of medicinal chemistry. 48(7)
The triphosphates of antiviral 2',3'-dideoxynucleosides (ddNs) are the active chemical species that inhibit viral DNA synthesis. The inhibition involves incorporation of ddNMP into DNA and subsequent chain termination. A conceivable strategy for anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f4265ca1fb55f2be14c81d517ca762
https://pubmed.ncbi.nlm.nih.gov/15801860
https://pubmed.ncbi.nlm.nih.gov/15801860
Autor:
Patrick Fagan, Jennifer L. Brooks, Tiffany Hurd, Vasanthakumar Rajappan, Nicholas A. Boyle, P. Dan Cook, Marija Prhavc, Yi Jin, Thomas W. Bruice, Fu Chen, Vivek K. Rajwanshi, Janet M Leeds, Guangyi Wang
Publikováno v:
Journal of medicinal chemistry. 47(27)
In search of active nucleoside 5'-triphosphate mimics, we have synthesized a series of AZT triphosphate mimics (AZT P3Ms) and evaluated their inhibitory effects on HIV-1 reverse transcriptase as well as their stability in fetal calf serum and in CEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d5fa371fcce03fc76df869cb83e25b
https://pubmed.ncbi.nlm.nih.gov/15615539
https://pubmed.ncbi.nlm.nih.gov/15615539
Autor:
Patrick Fagan, Kandasamy Sakthivel, Tiffany Hurd, Janet M. Leeds, Vasanthakumar Rajappan, Kathleen D. Tucker, Jennifer L. Brooks, Guangyi Wang, P. Dan Cook, Thomas W. Bruice
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 23(1-2)
IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′‐MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b5a6b59e253f6e8dfdbc415b2b85e2
https://pubmed.ncbi.nlm.nih.gov/15043157
https://pubmed.ncbi.nlm.nih.gov/15043157
Publikováno v:
Biochemistry. 40(42)
The herpes simplex virus type 1 origin binding protein (UL9) is a sequence-specific DNA binding protein. Several studies have demonstrated that UL9 binds to the 11-base pair sequence 5'-CGTTCGCACTT-3' primarily, or solely, through interaction with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22918832b15d07d408c14c8caf66b7b2
https://pubmed.ncbi.nlm.nih.gov/11601987
https://pubmed.ncbi.nlm.nih.gov/11601987