Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Thomas W. Beck"'
Autor:
Joseph C. Sun, Peter Emau, William R. Morton, Norbert Bischofberger, Kathryn E. Follis, Thomas W. Beck, Chy-Anh Tran, Che-Chung Tsai
Publikováno v:
Journal of Medical Primatology. 29:248-258
We report that simian immunodeficiency virus (SIV) infection in macaques is a valuable animal model for studying post-exposure chemoprophylaxis (PECP). PECP with the acyclic nucleoside reverse transcriptase inhibitors 9-(2-phosphonylmetho-xyethyl)ade
Autor:
Raoul E. Benveniste, Peter Emau, Kathryn E. Follis, Che-Chung Tsai, Norbert Bischofberger, Jeffrey D. Lifson, Thomas W. Beck, William R. Morton
Publikováno v:
Journal of Virology. 72:4265-4273
( R )-9-(2-Phosphonylmethoxypropyl)adenine (PMPA), an acyclic nucleoside phosphonate analog, is one of a new class of potent antiretroviral agents. Previously, we showed that PMPA treatment for 28 days prevented establishment of persistent simian imm
Effects of (R)-9-(2-Phosphonylmethoxypropyl)adenine Monotherapy on Chronic SIV Infection in Macaques
Autor:
Peter J. Dailey, Thomas W. Beck, Norbert Bischofberger, Che-Chung Tsai, Alexander Sabo, Kathryn E. Follis
Publikováno v:
AIDS Research and Human Retroviruses. 13:707-712
(R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA) acts as a reverse transcriptase inhibitor of retroviruses and has been shown to be effective against acute simian immunodeficiency virus (SIV) infection in macaques. To study its efficacy at different s
Autor:
Tracy A. Henriques, Paul J. Kruzich, Christopher L. Douglas, John J. Kremer, Hilton M. Jones, R. Dustan Sarazan, Thomas W. Beck
Publikováno v:
Journal of pharmacological and toxicological methods. 62(2)
Introduction Assessment of cardiovascular parameters, including the electrocardiogram (ECG) is required by the regulatory guidelines. In safety pharmacology studies, this is typically done using chronically implanted radiotelemetry devices in non-rod
Publikováno v:
Journal of pharmacological and toxicological methods. 62(1)
Introduction Animals are commonly used in toxicological research for the evaluation of drug effects on the cardiovascular system. Accurate and reproducible determination of blood pressure (BP) in conscious, manually restrained monkeys and dogs is a c
Autor:
Thomas W. Beck, Che-Chung Tsai, Raoul E. Benveniste, Alexander Sabo, Kathryn E. Follis, Norbert Bischofberger, Richard Grant, Roberta J. Black
Publikováno v:
Science (New York, N.Y.). 270(5239)
The efficacy of pre- and postexposure treatment with the antiviral compound (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) was tested against simian immunodeficiency virus (SIV) in macaques as a model for human immunodeficiency virus (HIV). PMPA was
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e36
Autor:
Thomas W. Beck, Amanda L. Hickman, Richard A. Macia, Derek J. Leishman, C. Michael Foley, Elaine M. Miller
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e36
Autor:
Thomas W. Beck, Elizabeth Lemke, R. Dustan Sarazan, C. Michael Foley, Zhuzai Xiang, John J. Kremer, Mark A. Osinski
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e47
Autor:
Christopher L. Douglas, Thomas W. Beck, R. Dustan Sarazan, C. Michael Foley, Jacqueline A. Walisser, John J. Kremer
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 62:e28