Zobrazeno 1 - 10
of 460
pro vyhledávání: '"Thomas W. Kensler"'
Autor:
Thomas W. Kensler, David L. Eaton
Publikováno v:
Toxins, Vol 16, Iss 11, p 496 (2024)
Aflatoxins are mycotoxins produced by Aspergillus flavus and several other related organisms and are common contaminants of numerous grains and nuts, especially maize (corn) and peanuts. Although, undoubtedly, aflatoxins have been present in the food
Externí odkaz:
https://doaj.org/article/bb05a2aa76c64c8fb5592c7c4612f2f3
Autor:
Christina Morgenstern, Isabel Lastres-Becker, Birsen Can Demirdöğen, Vera Marisa Costa, Andreas Daiber, Roberta Foresti, Roberto Motterlini, Sibel Kalyoncu, Burak I. Arioz, Sermin Genc, Monika Jakubowska, Ioannis P. Trougakos, Aleksandra Piechota-Polanczyk, Michel Mickael, Marlene Santos, Thomas W. Kensler, Antonio Cuadrado, Ian M. Copple
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103134- (2024)
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to mo
Externí odkaz:
https://doaj.org/article/f50d81e6b4e544bc8942767d3919a61a
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
Autor:
Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102845- (2023)
While it is well established that the KEAP1-NRF2 pathway regulates the main inducible cellular response to oxidative stress, this cytoprotective function of NRF2 could become deleterious to the host if it confers survival onto irreparably damaged cel
Externí odkaz:
https://doaj.org/article/05330e90b7e04718bade953250368fe1
Autor:
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W. Kensler, Dai Shiba, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight. These metabolic and physiological changes were largely driven by Nrf2 (NF-E2-related f
Externí odkaz:
https://doaj.org/article/4d30a972dc234a618c53b81a1176cb9d
Autor:
Jed W. Fahey, Thomas W. Kensler
Publikováno v:
Food Frontiers, Vol 2, Iss 3, Pp 235-239 (2021)
Abstract That phytochemicals are a critical part of enhancing healthspan is in our minds a linchpin of responsible public health messaging, yet, recent dietary guidelines and strategies for implementing precision nutrition largely ignore roles of phy
Externí odkaz:
https://doaj.org/article/3ef9279bc0cb4cd28e328f709d4b36e8
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background Adolescence and early adulthood has been identified as a critical time window for establishing breast cancer risk. Mammographic density is an independent risk factor for breast cancer that may be influenced by diet, but there has
Externí odkaz:
https://doaj.org/article/39890dc537c447e693fce5692bc7913d
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 1, Pp 24-37 (2019)
Qidong (Jiangsu, China) has been of interest to cancer epidemiologists and biologists because, until recently, it was an endemic area for liver cancer, having amongst the highest incidence rates in the world. The establishment of the Qidong Cancer Re
Externí odkaz:
https://doaj.org/article/5bd5abbc0ea7469a9d69eeb513ed3f24
Autor:
Jed W. Fahey, Thomas W. Kensler
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Broccoli sprouts are a convenient and rich source of the glucosinolate glucoraphanin, which can generate the chemopreventive agent sulforaphane through the catalytic actions of plant myrosinase or β-thioglucosidases in the gut microflora. Sulforapha
Externí odkaz:
https://doaj.org/article/24f80a7fb0934ab09e63687c94fdce95
Autor:
Jian-Guo Chen, Jian Zhu, Yong-Hui Zhang, Yong-Sheng Chen, Jian-Hua Lu, Yuan-Rong Zhu, Hai-Zhen Chen, Ai-Guo Shen, Gao-Ren Wang, John D. Groopman, Thomas W. Kensler
Publikováno v:
PeerJ, Vol 9, p e10600 (2021)
Background and aims: Liver cancer is one of the most dominant malignant tumors in the world. The trends of liver cancer mortality over the past six decades have been tracked in the epidemic region of Qidong, China. Using epidemiological tools, we exp
Externí odkaz:
https://doaj.org/article/4aefbb1c17b644cda28c75d31b73b80d
Autor:
Joshua W. Smith, Robert N. O’Meally, Sean M. Burke, Derek K. Ng, Jian-Guo Chen, Thomas W. Kensler, John D. Groopman, Robert N. Cole
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:595-607
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db7151b7981f112e9fe4129190df92d
https://doi.org/10.1021/jasms.2c00314
https://doi.org/10.1021/jasms.2c00314