Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Thomas W Sturgill"'
Autor:
Thomas W. Sturgill, Michael N. Hall
Publikováno v:
ACS chemical biology
ACS Chemical Biology
ACS Chemical Biology
TOR (Target of Rapamycin) is a highly conserved Ser/Thr kinase and a central controller of cell growth. Using the crystal structure of the related lipid kinase PI3KCgamma, we built a model of the catalytic region of TOR, from the FAT domain to near t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8238589534299abfb325a08e0aad39a8
http://pubs.acs.org/doi/abs/10.1021/cb900193e
http://pubs.acs.org/doi/abs/10.1021/cb900193e
Autor:
Michael N. Hall, Adiel Cohen, Melanie Diefenbacher, Mark Trautwein, Dietmar E. Martin, Thomas W. Sturgill
Publikováno v:
Eukaryotic Cell. 7:1819-1830
TOR is a structurally and functionally conserved Ser/Thr kinase found in two multiprotein complexes that regulate many cellular processes to control cell growth. Although extensively studied, the localization of TOR is still ambiguous, possibly becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e661bae49cc18a8603655a551d2c897
https://doi.org/10.1128/ec.00088-08
https://doi.org/10.1128/ec.00088-08
Autor:
Thomas W. Sturgill
Publikováno v:
Biochemical and Biophysical Research Communications. 371:1-4
The review highlights evidence for different functions in the cell cycle of the two MAP kinase kinases, MEK1 and MEK2, and the two MAP kinases, ERK1 and ERK2. Functional differences may explain why instances of cell cycle arrest can be MEK1 or MEK2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd355f9bbcb59175e822362e5ff9bf81
https://doi.org/10.1016/j.bbrc.2008.04.002
https://doi.org/10.1016/j.bbrc.2008.04.002
Autor:
Rikiro Fukunaga, Thomas W. Sturgill, William Ross, Takeshi Ueda, Carol A. Chrestensen, Rie Watanabe-Fukunaga, Andrew Eschenroeder
Publikováno v:
Genes to Cells. 12:1133-1140
Map kinase-interacting protein kinases 1 and 2 (MNK1, MNK2) function downstream of p38 and ERK MAP kinases, but there are large gaps in our knowledge of how MNKs are regulated and function. Mice deleted of both genes are apparently normal, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f2374e45ff0605791777ee810e6d37
https://doi.org/10.1111/j.1365-2443.2007.01122.x
https://doi.org/10.1111/j.1365-2443.2007.01122.x
Autor:
Thomas W. Sturgill, Carol A. Chrestensen, Andrew Eschenroeder, Jacquelyn K. Shuman, Mark T. Worthington, Hermann Gram
Publikováno v:
Journal of Biological Chemistry. 282:4243-4252
MAPK-interacting protein kinases 1 and 2 (MNK1 and MNK2) function downstream of p38 and ERK MAPK, but there are large gaps in our knowledge of how MNKs are regulated and function. As proteins activated in the HER2/Ras/Raf/ERK pathway, the MNKs are of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291f63ae114b51e8dedfea96529324a0
https://doi.org/10.1074/jbc.m607368200
https://doi.org/10.1074/jbc.m607368200
Autor:
Thomas W. Sturgill, Sirlester A. Parker, Jeffrey Shabanowitz, Katherine A. Larson, Konstantin Galaktionov, Philipp Kaldis, Zheng Fu, Raghu K. Chitta, Benjamin E. Turk, Steven M. Cohn, Matthew W. Lawrence, Donald F. Hunt
Publikováno v:
Molecular and Cellular Biology. 26:8639-8654
MAK (male germ cell-associated protein kinase) and MRK/ICK (MAK-related kinase/intestinal cell kinase) are human homologs of Ime2p in Saccharomyces cerevisiae and of Mde3 and Pit1 in Schizosaccharomyces pombe and are similar to human cyclin-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f737b20d05b432697915c176e663c27d
https://doi.org/10.1128/mcb.00816-06
https://doi.org/10.1128/mcb.00816-06
Autor:
Thomas W. Sturgill, Jeffrey Shabanowitz, Melanie J. Schroeder, Carol A. Chrestensen, Mark T. Worthington, Donald F. Hunt, Jared W. Pelo
Publikováno v:
Journal of Biological Chemistry. 279:10176-10184
MAPKAP kinase 2 (MK2) is required for tumor necrosis factor synthesis. Tristetraprolin (TTP) binds to the 3'-untranslated region of tumor necrosis factor mRNA and regulates its fate. We identified in vitro and in vivo phosphorylation sites in TTP usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9641c38678b72306f46acb02422b3d07
https://doi.org/10.1074/jbc.m310486200
https://doi.org/10.1074/jbc.m310486200
Publikováno v:
Journal of Biological Chemistry. 277:27733-27741
The carboxyl-terminal domain (CTD) of the p90 ribosomal S6 kinases (RSKs) is an important regulatory domain in RSK and a model for kinase regulation of FXXFXF(Y) motifs in AGC kinases. Its properties had not been studied. We reconstituted activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eee39f06cc56a04698dc66c27a2e240
https://doi.org/10.1074/jbc.m202663200
https://doi.org/10.1074/jbc.m202663200
Publikováno v:
Journal of Biological Chemistry. 276:38449-38456
The serum response element (SRE) of the c-fos promoter is a convergence point for mitogenic signaling pathways. Several transcription factors regulate SRE, including serum response factor (SRF), ternary complex factors, and CCAAT/enhancer-binding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4200dea991aa19f7e05dda21e32232d6
https://doi.org/10.1074/jbc.m102165200
https://doi.org/10.1074/jbc.m102165200
Autor:
Jorge Santiago, Thomas W Sturgill
Publikováno v:
Biochemistry and Cell Biology. 79:141-152
We previously demonstrated that a protein kinase responsible for phosphorylating 40S ribosomal subunits is activated in quiescent Artemia franciscana embryos within 15 min of restoration of normal tonicity and incubation at 30°C. Here, we identify t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659b131e581005f52fb598a7110abef3
https://doi.org/10.1139/o01-003
https://doi.org/10.1139/o01-003