Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Thomas W, Rösler"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Modulation of the Nrf2 pathway, a master regulator of the antioxidant response and cellular metabolism, has been suggested as a promising therapeutic strategy in tauopathies, a heterogeneous group of neurodegenerative disorders characterized
Externí odkaz:
https://doaj.org/article/8b9f4e374bc34b5c96693057c8ff5a17
Autor:
Christina V. Tauber, Sigrid C. Schwarz, Thomas W. Rösler, Thomas Arzberger, Steve Gentleman, Otto Windl, Mandy Krumbiegel, André Reis, Viktoria C. Ruf, Jochen Herms, Günter U. Höglinger
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic variants (H1 and H2). Homozygosity for the more common haplotype H1 is associated with an i
Externí odkaz:
https://doaj.org/article/ae97f9d9d91942cbbbf9d8ff8dee7c6c
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0283943 (2023)
The activation of the unfolded protein response, particularly via the PERK pathway, has been suggested as a promising therapeutic approach in tauopathies, a group of neurodegenerative disorders characterized by the abnormal phosphorylation and aggreg
Externí odkaz:
https://doaj.org/article/c49ee08b9b064b48af2dd9d8be8e186e
Autor:
Ali S. Shalash, Thomas W. Rösler, Ibrahim Y. Abdelrahman, Hatem S. Abulmakarem, Stefanie H. Müller, Franziska Hopfner, Gregor Kuhlenbäumer, Günter U. Höglinger, Mohamed Salama
Publikováno v:
Heliyon, Vol 7, Iss 7, Pp e07469- (2021)
Pantothenate kinase-associated neurodegeneration (PKAN) is a rare hereditary neurodegenerative disease characterized by an accumulation of iron within the brain. In the present report, we describe a family with 4 affected siblings presenting with var
Externí odkaz:
https://doaj.org/article/f483bbcf535747b284208eaac29143b7
Autor:
Elisabeth Findeiss, Sigrid C. Schwarz, Valentin Evsyukov, Thomas W. Rösler, Matthias Höllerhage, Tasnim Chakroun, Niko-Petteri Nykänen, Yimin Shen, Wolfgang Wurst, Michael Kohl, Jörg Tost, Günter U. Höglinger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Growing evidence suggests that epigenetic mechanisms like microRNA-mediated transcriptional regulation contribute to the pathogenesis of parkinsonism. In order to study the influence of microRNAs (miRNAs), we analyzed the miRNome 2 days prior to majo
Externí odkaz:
https://doaj.org/article/5ea6ed3d0f4e48c1a2e0aa7a04f73b6a
Autor:
Julius Bruch, Hong Xu, Thomas W Rösler, Anderson De Andrade, Peer‐Hendrik Kuhn, Stefan F Lichtenthaler, Thomas Arzberger, Konstanze F Winklhofer, Ulrich Müller, Günter U Höglinger
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 371-384 (2017)
Abstract The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms underlying this association, we explored PERK activity in brains of
Externí odkaz:
https://doaj.org/article/48f7047ad56f4407b0979af9f17212d7
Autor:
Thomas W. Rösler, Manuela Pendziwiat, Mohamed Salama, Ali S. Shalash, Gregor Kuhlenbäumer, Günter U. Höglinger, Stefanie H. Müller, Franziska Hopfner
Publikováno v:
Neurogenetics 22(2), 143-147 (2021). doi:10.1007/s10048-021-00639-4
Neurogenetics
Neurogenetics
Ataxia telangiectasia is a rare autosomal recessive multisystem disorder caused by mutations in the gene of ATM serine/threonine kinase. It is characterized by neurodegeneration, leading to severe ataxia, immunodeficiency, increased cancer susceptibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f4b1fd47069f1a32198c2ed1a4da12
https://doi.org/10.1007/s10048-021-00639-4
https://doi.org/10.1007/s10048-021-00639-4
Autor:
Günter U. Höglinger, Wolfgang Wurst, Matthias Höllerhage, Natascha Fussi, Christian Behrends, Thomas W. Rösler
Publikováno v:
Neuropharmacology 149, 13-26 (2019). doi:10.1016/j.neuropharm.2019.01.023
Pathological aggregates of alpha-synuclein are the common hallmarks of synucleinopathies, including Parkinson's disease. There is currently no disease-modifying therapy approved for neurodegenerative synucleinopathies. The induction of macroautophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e929d4d566ceb29c99157505daf15
https://doi.org/10.1016/j.neuropharm.2019.01.023
https://doi.org/10.1016/j.neuropharm.2019.01.023
Autor:
Thomas W Rösler, Andreas Matusch, Damiano Librizzi, Oscar Arias-Carrión, Nils Freundlieb, Helmut Hoeffken, Wolfgang H Oertel, Candan Depboylu, Günter U Höglinger
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102397 (2014)
With the aim to develop beneficial tracers for cerebral tumors, we tested two novel 5-iodo-2'-deoxyuridine (IUdR) derivatives, diesterified at the deoxyribose residue. The substances were designed to enhance the uptake into brain tumor tissue and to
Externí odkaz:
https://doaj.org/article/6b5898f7f8b64014bc6b4d20e7885902
Autor:
Matthias Höllerhage, Roman Deck, Anderson De Andrade, Gesine Respondek, Hong Xu, Thomas W Rösler, Mohamed Salama, Thomas Carlsson, Elizabeth S Yamada, Seham A Gad El Hak, Michel Goedert, Wolfgang H Oertel, Günter U Höglinger
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113557 (2014)
The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologica
Externí odkaz:
https://doaj.org/article/8ba9762adc4a4cb3900464898ed10fc0