Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas W, Mc Closkey"'
Autor:
Weiguo Zhong, Christina D. Swenson, Joanne Cuomo, Yeji Cho, Thomas W. Mc Closkey, Chengsen Xue
Publikováno v:
Cancer Research. 81:512-512
The success of inhibiting PD1 on T cells for cancer immunotherapy initiated strong interest in studying therapeutic antibodies to alter the adaptive immune system. As the knowledge of neoantigens, oncogenes, and autoantigens is rapidly accelerating,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1925477f977a3b59d778c2377a0faaa
https://doi.org/10.1158/1538-7445.am2021-512
https://doi.org/10.1158/1538-7445.am2021-512
Recommendations for the development and validation of flow cytometry-based receptor occupancy assays
Autor:
Barry van der Strate, John Ferbas, Virginia Litwin, Tim Wyant, Thomas W. Mc Closkey, Jennifer J. Stewart, Cherie Green, Meina Liang, Yuanxin Xu, Nicholas Jones, Carl-Magnus Högerkorp, David Lanham, Danice E. C. Wilkins, Alan Lackey, Kamila Czechowska, Maxime Moulard
Publikováno v:
Cytometry Part B: Clinical Cytometry. 90:141-149
Receptor occupancy measurements demonstrate the binding of a biotherapeutic agent to its extra-cellular target and represent an integral component of the pharmacodynamic (PD) portfolio utilized to advance the development and commercialization of a th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e43b91bccdb2e4f4b1d17d69167d9d7
https://doi.org/10.1002/cyto.b.21339
https://doi.org/10.1002/cyto.b.21339
Autor:
Joanne Cuomo, Chengsen Xue, Chrinstina D. Swenson, Kai Chen, Thomas W. Mc Closkey, Lucie-Emily Rows
Publikováno v:
Cancer Research. 80:5593-5593
Personalized immunotherapy for cancer has become an effective treatment choice in certain oncology indications. To successfully develop such therapeutic candidates requires a deep understanding of the biology including the interaction between a varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fc43fa351ac0c5a7c26a5bbeb54163
https://doi.org/10.1158/1538-7445.am2020-5593
https://doi.org/10.1158/1538-7445.am2020-5593
Autor:
Kasia E. Cortes, Hong Ji, Anne Charlotte Hegelund, Carl-Magnus Högerkorp, Karen J. Quadrini, Chengsen Xue, Thomas W. Mc Closkey, Susan M. Kennelly
Publikováno v:
Cytometry Part B: Clinical Cytometry. 90:177-190
The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is implicated in a variety of autoimmune and inflammatory disorders. The objective of the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cae086df78ca16821899ad2f14a709e
https://doi.org/10.1002/cyto.b.21260
https://doi.org/10.1002/cyto.b.21260
Publikováno v:
Cancer Research. 78:5588-5588
Circulating tumor cell (CTC) detection and characterization have recently become an integral part of precision medicine. Several large, multicenter clinical studies confirmed that the prevalence of CTC is a useful predictor of treatment efficacy in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62ed76c01764bc31a8b8b82e14583081
https://doi.org/10.1158/1538-7445.am2018-5588
https://doi.org/10.1158/1538-7445.am2018-5588
Publikováno v:
Cancer Research. 77:2605-2605
Flow cytometric assessment of cellular and intracellular biomarkers facilitates the development of new classes of cancer immunotherapy therapeutics. This powerful tool has multiple applications including 1) detecting PD1, PDL-1 and caspase-3 for apop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ab4a92d9f8b999c43f7c4db2ad951d
https://doi.org/10.1158/1538-7445.am2017-2605
https://doi.org/10.1158/1538-7445.am2017-2605
Autor:
Karen J, Quadrini, Anne Charlotte, Hegelund, Kasia E, Cortes, Chengsen, Xue, Susan M, Kennelly, Hong, Ji, Carl-Magnus, Högerkorp, Thomas W, Mc Closkey
Publikováno v:
Cytometry. Part B, Clinical cytometry. 90(2)
The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is implicated in a variety of autoimmune and inflammatory disorders. The objective of the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9b7544227218e35ccb088b1e6023ce8
https://pubmed.ncbi.nlm.nih.gov/26084468
https://pubmed.ncbi.nlm.nih.gov/26084468
Autor:
Savita Pahwa, Thomas W. Mc Closkey
Publikováno v:
Clinical Immunology Newsletter. 19:93-102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdbc90c1ca541f911bff7e2642366170
https://doi.org/10.1016/s0197-1859(00)88207-2
https://doi.org/10.1016/s0197-1859(00)88207-2
Publikováno v:
Cancer Immunology Research. 4:A026-A026
The measurement of regulatory T cells (Treg) by flow cytometry provides important information in the assessment of new anti-tumor drug candidates, particularly in regards to an immuno-oncology mechanism of action. An assay was validated using a fit-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c10ef0a48aa05485b1473ff0b9b6d2
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a026
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a026
Publikováno v:
Hepatology. 16:191-203
Endothelial cells and macrophages are located within the hepatic sinusoids. These two cell types play an important role in the clearance of bacterially derived lipopolysaccharide from the portal circulation. Our laboratory has previously demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa3b14cbef583f29e24da58184d5d31
https://doi.org/10.1002/hep.1840160130
https://doi.org/10.1002/hep.1840160130