Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Thomas Vierbuchen"'
Publikováno v:
eLife, Vol 11 (2022)
Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant
Externí odkaz:
https://doaj.org/article/637ec108529642a3a214676a933beab7
Autor:
Ashley E. Webb, Elizabeth A. Pollina, Thomas Vierbuchen, Noelia Urbán, Duygu Ucar, Dena S. Leeman, Ben Martynoga, Madhavi Sewak, Thomas A. Rando, François Guillemot, Marius Wernig, Anne Brunet
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 477-491 (2013)
FOXO transcription factors are central regulators of longevity from worms to humans. FOXO3, the FOXO isoform associated with exceptional human longevity, preserves adult neural stem cell pools. Here, we identify FOXO3 direct targets genome-wide in pr
Externí odkaz:
https://doaj.org/article/ab509ff2434c4542a707bc7bd4f32a99
Autor:
Renhe Luo, Jielin Yan, Jin Woo Oh, Wang Xi, Dustin Shigaki, Wilfred Wong, Hyunwoo Cho, Dylan Murphy, Ronald Cutler, Bess P. Rosen, Julian Pulecio, Dapeng Yang, Rachel Glenn, Tingxu Chen, Qing V. Li, Thomas Vierbuchen, Simone Sidoli, Effie Apostolou, Danwei Huangfu, Michael A. Beer
Publikováno v:
bioRxiv
Comprehensive enhancer discovery is challenging because most enhancers, especially those affected in complex diseases, have weak effects on gene expression. Our network modeling revealed that nonlinear enhancer-gene regulation during cell state trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff85707b0fc48aacfb290c495b7ea75
https://doi.org/10.1101/2023.03.07.531569
https://doi.org/10.1101/2023.03.07.531569
Autor:
Justin Perry, Alissa Trzeciak, Waleska Saitz Rojas, Adam Krebs, Giulia Zago, Ya-Ting Wang, Zhaoquan Wang, Pedro Saavedra, Jian Xie, Chou-Long Huang, Michael Overholtzer, Michael Glickman, Christopher Parkhurst, Thomas Vierbuchen, Christopher Lucas
The appropriate development of myeloid progenitors into macrophages, the body’s professional phagocyte, is essential for organismal development, especially in mammals1. This dependence is exemplified by the observation that loss-of-function mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b849bf3b9f52f7367b2767fc1e988c95
https://doi.org/10.21203/rs.3.rs-1344322/v1
https://doi.org/10.21203/rs.3.rs-1344322/v1
Publikováno v:
eLife. 11
Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6f2c026cfb5b71f1e8a21ec2746175
https://doi.org/10.7554/elife.76500
https://doi.org/10.7554/elife.76500
Autor:
Jennifer A. Zallen, Lorenz Studer, Anna-Katerina Hadjantonakis, Thomas Vierbuchen, Mary K. Baylies, Eric C. Lai, Alexandra L. Joyner, Zhirong Bao, Maria Jasin, Danwei Huangfu, Elizabeth Lacy
Publikováno v:
Cell. 184:1123-1126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393cc7f3b30281e66ddddec86c4146df
https://doi.org/10.1016/j.cell.2021.01.054
https://doi.org/10.1016/j.cell.2021.01.054
Autor:
Aristotelis Tsirigos, Hynek Wichterle, Effie Apostolou, Boaz E. Aronson, Emily Swanzey, Abhishek Sinha, Rachel A. Glenn, Annabel Azziz, Veevek Shah, Laurianne Scourzic, Jiexi Li, Meelad M. Dawlaty, Matthias Stadtfeld, Inbal Caspi, Thomas Vierbuchen, Bobbie Pelham-Webb, Andreas Kloetgen, Alexander Polyzos
Publikováno v:
Dev Cell
3065.e5
Developmental cell
United States
3065.e5
Developmental cell
United States
Summary Loss of imprinting (LOI) results in severe developmental defects, but the mechanisms preventing LOI remain incompletely understood. Here, we dissect the functional components of the imprinting control region of the essential Dlk1-Dio3 locus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812a52a1951b91516b84f961b573f74d
https://europepmc.org/articles/PMC8628258/
https://europepmc.org/articles/PMC8628258/
Autor:
Emmy Li, Eric C. Griffith, Lisa D. Boxer, M. Aurel Nagy, Sinisa Hrvatin, Michael E. Greenberg, Andrew Silberfeld, William Renthal, Thomas Vierbuchen
Publikováno v:
Nature neuroscience
In females with X-linked genetic disorders, wild-type and mutant cells coexist within brain tissue because of X-chromosome inactivation, posing challenges for interpreting the effects of X-linked mutant alleles on gene expression. We present a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692d571f24608a3fc81d17210124001
https://pubmed.ncbi.nlm.nih.gov/30455458
https://pubmed.ncbi.nlm.nih.gov/30455458
Autor:
Christopher J. Cowley, Michael E. Greenberg, David A. Harmin, Thomas Vierbuchen, Charles W. M. Roberts, Emi Ling, Xiaofeng Wang, Cameron H. Couch
Publikováno v:
Molecular cell. 68(6)
Enhancer elements are regulatory sequences within genomes that direct the selective expression of genes so that genetically identical cells can differentiate and acquire the highly specialized forms and functions required to build a functioning anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a089e759101eceeb5942c44d00cb3b83
https://pubmed.ncbi.nlm.nih.gov/29272704
https://pubmed.ncbi.nlm.nih.gov/29272704