Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Thomas Vickery"'
Autor:
Adam J. Fine, Megan Roth, Eric M. Phillips, Daniel J. Muzzio, Stephen M. Dalby, Ralph Zhao, Alexei Kalinin, Ryan Flessner, Cuixian Yang, Stephen Van Cleaf, Analisse Rosario, Theodore R. Furman, Tao Wang, Thomas Vickery
Publikováno v:
Organic Process Research & Development. 25:1979-1987
Autor:
Joshua Bader, Charles Orella, Rory T. Gallagher, Thomas L. Seidl, David R. Stuart, Thomas Vickery
Publikováno v:
Organic Process Research & Development. 23:1269-1274
Herein, we describe the discovery and development of a method to exchange the counteranion component of diaryliodonium salts, which is a critical step for their use in chemical synthesis. The metho...
Autor:
Josep Saurí, Michael J. Ardolino, Zhiguo J. Song, Lu Chen, Daniel J. Muzzio, Lushi Tan, Thomas Vickery, Jingjun Yin, Ji Qi, Chaomin Li, Yu-hong Lam, Ralph Zhao, Theodore A. Martinot, Matthew L. Maddess
Publikováno v:
Organic Process Research & Development. 23:1178-1190
The development of a stereospecific synthesis of a IDO1-selective inhibitor is described. The synthetic strategy toward enabling early discovery efforts along with additional findings pertaining to...
Publikováno v:
Organic Syntheses. 96:137-149
Autor:
Thomas Vickery, Megan Roth, Michael Toth, Shane Stone, Don Bachert, Elizabeth Fisher, Charles Orella, Josh Bader, Dan Muzzio
Publikováno v:
Process Safety Progress. 40
Autor:
Harold B. Wood, Nobuyoshi Yasuda, Rebecca T. Ruck, Ephraim M. Bassan, Thomas Vickery, Izzat T. Raheem, Dienemann Erik A, Khateeta M. Emerson, Guy R. Humphrey, David M. Tschaen
Publikováno v:
Organic Process Research & Development. 17:1611-1616
Process safety is an important consideration not only when conducting reactions on manufacturing scale, but also on lab and kilo lab scale. This contribution presents a discussion of Merck’s Reaction Review policy, originally specific to Process Ch
Publikováno v:
Organic Process Research & Development. 15:443-448
A safe and practical procedure for the N-oxidation of pyrazolopyridine 4 using meta-chloroperbenzoic acid (m-CPBA) in acetic acid is described. Key safety experiments are outlined which have led to...
Autor:
Karla G. Childers, Guy R. Humphrey, Thientu Lam, Michel Journet, Thomas Vickery, Zhihui Peng, Donald Bachert, Jeffrey T. Kuethe
Publikováno v:
Organic Process Research & Development. 13:576-580
A safe and practical strategy has been developed for the large-scale preparation of imidazole 7. The key transformation involved the Wolff−Kishner reduction of the sterically demanding neopentyl-trifluoromethylcyclopropyl imidazole ketone 8. The de
Autor:
Jeremy P. Scott, Adrian Goodyear, Kathleen J. Kumke, Khateeta M. Emerson, Karel M. J. Brands, Thomas Vickery, Sarah E. Brewer, and Thientu Lam, Donald Bachert
Publikováno v:
Organic Process Research & Development. 9:1009-1012
Thermal stability testing of 4-methoxybenzyl chloride is described herein, from which safe storage and handling conditions have been defined.
Autor:
Donald Bachert, Fuh-Rong Tsay, Thomas Vickery, Johnnie L. Leazer, Raymond Cvetovich, Ulf H. Dolling
Publikováno v:
The Journal of organic chemistry. 68(9)
An improved and efficient bromination of 3,5-bis(trifluoromethyl)benzene was developed. A safe and reliable preparation of the potentially explosive 3,5-bis(trifluoromethyl)phenyl Grignard and 3-trifluoromethylphenyl Grignard reagents, from the precu