Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas V. Karathanos"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optogenetic defibrillation of hearts expressing light-sensitive cation channels (e.g., ChR2) has been proposed as an alternative to conventional electrotherapy. Past modeling work has shown that ChR2 stimulation can depolarize enough myocardium to in
Externí odkaz:
https://doaj.org/article/9db868208fcc41a4a222cece295bf770
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
Autor:
Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J. Alvarado, Igor Dolgalev, Thomas V. Karathanos, Kabir Malkani, Chantal J.M. Van Opbergen, Joanne J.A. van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E. Morley, William A. Coetzee, Natalia A. Trayanova, Michael J. Ackerman, Toon A.B. van Veen, Hector H. Valdivia, Mario Delmar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adul
Externí odkaz:
https://doaj.org/article/4417834a57fb40c18499881ece963bc6
Publikováno v:
Clinical Medicine Insights: Cardiology, Vol 2016, Iss Suppl. 1, Pp 47-60 (2016)
Externí odkaz:
https://doaj.org/article/aaf58820935843ca83fe59e3ebcaaec0
Publikováno v:
JACC: Clinical Electrophysiology. 4:155-167
Cardiac optogenetics is an emergent research area involving the delivery of light-sensitive proteins (opsins) to excitable heart tissue to enable optical modulation of cardiac electrical function. Optogenetic stimulation has many noteworthy advantage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704e40bc42d3ef94fb9879e3047808d6
https://doi.org/10.1016/j.jacep.2017.12.006
https://doi.org/10.1016/j.jacep.2017.12.006
Autor:
Robert C. Blake, Natalia A. Trayanova, Patrick M. Boyle, Sohail Zahid, Thomas V. Karathanos, Michael J. Murphy
Publikováno v:
The Journal of Physiology. 596:181-196
KEY POINTS Optogenetics has emerged as a potential alternative to electrotherapy for treating heart rhythm disorders, but its applicability for terminating atrial arrhythmias remains largely unexplored. We used computational models reconstructed from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5d4b6032241582bb26f9656f06bdd4
https://doi.org/10.1113/jp275264
https://doi.org/10.1113/jp275264
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
Autor:
Adriana Heguy, Marina Cerrone, Eli Rothenberg, Joanne J.A. Van Bavel, Esperanza Agullo-Pascual, Mingliang Zhang, Alejandra Leo-Macias, Kabir Malkani, Hua Qian Yang, Jérôme Montnach, Thomas V. Karathanos, William A. Coetzee, Yan-Ting Zhao, Gregory E. Morley, Héctor H. Valdivia, Feng-Xia Liang, Natalia A. Trayanova, Michael J. Ackerman, Xianming Lin, Francisco J. Alvarado, David J. Tester, Toon A.B. van Veen, Carolina Vasquez, Mario Delmar, Chantal J. M. van Opbergen, Steven J. Fowler, Igor Dolgalev
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications [E], 8(1). Nature Publishing Group
Nature Communications
Nature Communications [E], 8(1). Nature Publishing Group
Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcca7cfc8742918fb4f3ac730fec04b
https://doaj.org/article/4417834a57fb40c18499881ece963bc6
https://doaj.org/article/4417834a57fb40c18499881ece963bc6
Autor:
Tobias Bruegmann, Hermenegild Arevalo, Bernd K. Fleischmann, Philipp Sasse, Thomas V. Karathanos, Christoph C. Vogt, Patrick M. Boyle, Natalia A. Trayanova
Publikováno v:
Journal of Clinical Investigation. 126:3894-3904
Ventricular arrhythmias are among the most severe complications of heart disease and can result in sudden cardiac death. Patients at risk currently receive implantable defibrillators that deliver electrical shocks to terminate arrhythmias on demand.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f272329401e42a6e9d2e1a71f4990e26
https://doi.org/10.1172/jci88950
https://doi.org/10.1172/jci88950
Publikováno v:
The Journal of Physiology. 594:6879-6891
Key points Optogenetics-based defibrillation, a theoretical alternative to electrotherapy, involves expression of light-sensitive ion channels in the heart (via gene or cell therapy) and illumination of the cardiac surfaces (via implanted LED arrays)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905ebc2afd955f2025d55e7891cfc1c2
https://doi.org/10.1113/jp271739
https://doi.org/10.1113/jp271739
Publikováno v:
Computers in Biology and Medicine. 65:200-208
Cardiac optogenetics is emerging as an exciting new potential avenue to enable spatiotemporally precise control of excitable cells and tissue in the heart with low-energy optical stimuli. This approach involves the expression of exogenous light-sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753554564c2697957253ecdfb4becc69
https://doi.org/10.1016/j.compbiomed.2015.04.036
https://doi.org/10.1016/j.compbiomed.2015.04.036
Publikováno v:
Trends in Cardiovascular Medicine. 25:73-81
Optogenetics is an exciting new technology in which viral gene or cell delivery is used to inscribe light sensitivity in excitable tissue to enable optical control of bioelectric behavior. Initial progress in the fledgling domain of cardiac optogenet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0c22c17dc2e6ca1a2a24bfb1d11bb6
https://doi.org/10.1016/j.tcm.2014.10.004
https://doi.org/10.1016/j.tcm.2014.10.004