Výsledky vyhledávání - "Thomas V, Burlin"

Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-11C]leucine PET

Autor: Kathleen C Schmidt, Inna Loutaev, Thomas V Burlin, Audrey Thurm, Carrie Sheeler, Carolyn Beebe Smith

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 42:1666-1675

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Fragile X mental retardation protein, a putative translation suppressor, is significantly reduced in FXS. The prevailing hypothesis is that rates of cerebral prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f277076c0538508afc00041e21f1766
https://doi.org/10.1177/0271678x221090997

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Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1

Autor: Kathleen C, Schmidt, Inna, Loutaev, Thomas V, Burlin, Audrey, Thurm, Carrie, Sheeler, Carolyn Beebe, Smith

Publikováno v: J Cereb Blood Flow Metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4ef634f2d5813ae77e6c7e3f91f8c45
https://pubmed.ncbi.nlm.nih.gov/35350914

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Propofol Anesthesia Does Not Alter Regional Rates of Cerebral Protein Synthesis Measured with l-[1-11C]Leucine and PET in Healthy Male Subjects

Autor: Shrinivas Bishu, Thomas V Burlin, Peter Herscovitch, Bik-Kee Vuong, Carolyn Beebe Smith, Michael A. Channing, Zhong-Hua Liu, Lisa M. Horowitz, Zengyan Xia, Zenaide M.N. Quezado, Aaron Unterman, Tianjiang Huang, Alan J. Zametkin, Mei Qin, Kathleen C Schmidt

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 29:1035-1047

We report regional rates of cerebral protein synthesis (rCPS) in 10 healthy young males, each studied under two conditions: awake and anesthetized with propofol. We used the quantitative l-[1-11C]leucine positron emission tomography (PET) method to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7395e69f0ecabb9775c9c028f6c03f
https://doi.org/10.1038/jcbfm.2009.7

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Cerebral Protein Synthesis in a Knockin Mouse Model of the Fragile X Premutation

Autor: Michael Kader, Mei Qin, Renate K. Hukema, Tianjian Huang, Carolyn Beebe Smith, Zhong-Hua Liu, Zachary Zeidler, Thomas V Burlin, Zengyan Xia

Publikováno v: ASN Neuro, Vol 6 (2014)
ASN NEURO

The (CGG)n-repeat in the 5′-untranslated region of the fragile X mental retardation gene ( FMR1) gene is polymorphic and may become unstable on transmission to the next generation. In fragile X syndrome, CGG repeat lengths exceed 200, resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277cf77fcd74e9677a7bf13409e56b88
https://doaj.org/article/95d23df1c12f40fbbc8c9243df63f321

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Altered cerebral protein synthesis in fragile X syndrome: studies in human subjects and knockout mice

Autor: Tianjiang Huang, Lisa M. Horowitz, Carolyn Beebe Smith, Mei Qin, Shrinivas Bishu, Zengyan Xia, Kathleen C Schmidt, Zenaide M.N. Quezado, Thomas V Burlin, Alan J. Zametkin

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 33(4)

Dysregulated protein synthesis is thought to be a core phenotype of fragile X syndrome (FXS). In a mouse model ( Fmr1 knockout (KO)) of FXS, rates of cerebral protein synthesis (rCPS) are increased in selective brain regions. We hypothesized that rCP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461dc25cac17931ed2e09cdeeea5076a
https://pubmed.ncbi.nlm.nih.gov/23299245

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Regional rates of cerebral protein synthesis measured with L-[1-11C]leucine and PET in conscious, young adult men: normal values, variability, and reproducibility

Autor: Aaron Unterman, Carolyn Beebe Smith, Peter Herscovitch, Zengyan Xia, Shrinivas Bishu, Zhong-Hua Liu, Shielah Conant, Tianjiang Huang, Kathleen C Schmidt, Mei Qin, Thomas V Burlin, Alan J. Zametkin, Michael A. Channing

We report regional rates of cerebral protein synthesis (rCPS) measured with the fully quantitative l-[1-11C]leucine positron emission tomography (PET) method. The method accounts for the fraction (Λ) of unlabeled amino acids in the precursor pool fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827e5f66dd8934286aeb54aa72ebf4fe
https://europepmc.org/articles/PMC2775471/

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Use of acute hyperphenylalaninemia in rhesus monkeys to examine sensitivity and stability of the L-[1-11C]leucine method for measurement of regional rates of cerebral protein synthesis with PET

Autor: Zhong-Hua Liu, Thomas V Burlin, Michael A. Channing, Zengyan Xia, Tianjiang Huang, Mei Qin, Kathleen C Schmidt, Shrinivas Bishu, Bee Kee Vuong, Jeff Bacon, Carolyn Beebe Smith, Peter Herscovitch

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28(7)

We have previously shown by direct comparison with autoradiographic and biochemical measurements that the l-[1-11C]leucine positron emission tomography method provides accurate determinations of regional rates of cerebral protein synthesis (rCPS) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e6e2e5e95619c735997159eb6fce9b
https://pubmed.ncbi.nlm.nih.gov/18431402

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R-Baclofen Reverses a Social Behavior Deficit and Elevated Protein Synthesis in a Mouse Model of Fragile X Syndrome

Autor: Leland Krych, Tingrui Zhao, Zengyan Xia, Mei Qin, Carolyn Beebe Smith, Thomas V Burlin, Tianjian Huang, Zachary Zeidler, Michael Kader

Publikováno v: International Journal of Neuropsychopharmacology

Background: Fragile X syndrome (FXS) is the most common known inherited form of intellectual disability and the single genomic cause of autism spectrum disorders. It is caused by the absence of a fragile X mental retardation gene ( Fmr1 ) product, FM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dafd99fa6036aabded33fda28edcf1
https://doi.org/10.1093/ijnp/pyv034

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Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse

Autor: Julia Kang, Thomas V Burlin, Chunhui Jiang, Mei Qin, Carolyn Beebe Smith

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(20)

Methylation-induced transcriptional silencing of the fragile X mental retardation-1 (Fmr1) gene leads to absence of the gene product, fragile X mental retardation protein (FMRP), and consequently fragile X syndrome (FrX), an X-linked inherited form o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99369147655dd8e6196554c79c846d30
https://pubmed.ncbi.nlm.nih.gov/15901791

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Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: I. Kinetic modeling approach

Autor: Carolyn Beebe Smith, Mei Qin, Michelle Cook, Julia Kang, Kathleen C Schmidt, Thomas V Burlin

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(5)

Measurements of regional rates of cerebral protein synthesis (rCPS) require correction for the effect of recycling of tissue amino acids back into the precursor pool for protein synthesis. The fraction of the precursor pool derived from arterial plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f68a8517adfc5ee55685a623bf1cc39
https://pubmed.ncbi.nlm.nih.gov/15703696

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