Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Thomas Turbyville"'
Autor:
Debanjan Goswami, De Chen, Yue Yang, Prabhakar R Gudla, John Columbus, Karen Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell, William Burgan, Vanessa Wall, Dominic Esposito, Dhirendra K Simanshu, Felice C Lightstone, Dwight V Nissley, Frank McCormick, Thomas Turbyville
Publikováno v:
eLife, Vol 9 (2020)
The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-dom
Externí odkaz:
https://doaj.org/article/c798200b000d4c1ab8ba16fab0ce9c68
Autor:
Helgi I. Ingólfsson, Harsh Bhatia, Fikret Aydin, Tomas Oppelstrup, Cesar A. López, Liam G. Stanton, Timothy S. Carpenter, Sergio Wong, Francesco Di Natale, Xiaohua Zhang, Joseph Y. Moon, Christopher B. Stanley, Joseph R. Chavez, Kien Nguyen, Gautham Dharuman, Violetta Burns, Rebika Shrestha, Debanjan Goswami, Gulcin Gulten, Que N. Van, Arvind Ramanathan, Brian Van Essen, Nicolas W. Hengartner, Andrew G. Stephen, Thomas Turbyville, Peer-Timo Bremer, S. Gnanakaran, James N. Glosli, Felice C. Lightstone, Dwight V. Nissley, Frederick H. Streitz
Publikováno v:
Journal of Chemical Theory and Computation. 19:2658-2675
Autor:
Megan Rigby, John Columbus, Vanessa Wall, Dominic Esposito, Thomas Turbyville, Dhirendra Simanshu, Dwight Nissley, Frank McCormick, Anna Maciag
Publikováno v:
Molecular Cancer Research. 21:B027-B027
KRAS mutations occur in roughly 15% of cancer patients, with KRAS G12D, KRAS G12V, and KRAS G12C substitutions constituting the majority of these cases. Cancer types also display puzzling preferences for certain RAS mutations; for instance, 49% of pa
Autor:
Xiyu Yi, Rebika Shrestha, Torin McDonald, De Chen, Harsh Bhatia, Valerio Pascucci, Thomas Turbyville, Peer-Timo Bremer
Single particle tracking (SPT) is an indispensable tool for scientific studies. However, SPT for datasets with a high density of particles is still challenging, especially for the study of particle interactions where the point spread functions (PSFs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c708c279b139a21558847fe7c1631276
https://doi.org/10.1101/2022.05.13.491828
https://doi.org/10.1101/2022.05.13.491828
Autor:
Kien Nguyen, Cesar A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale, Timothy Travers, Timothy H. Tran, Albert H. Chan, Harsh Bhatia, Peter H. Frank, Marco Tonelli, Xiaohua Zhang, Gulcin Gulten, Tyler Reddy, Violetta Burns, Tomas Oppelstrup, Nick Hengartner, Dhirendra K. Simanshu, Peer-Timo Bremer, De Chen, James N. Glosli, Rebika Shrestha, Thomas Turbyville, Frederick H. Streitz, Dwight V. Nissley, Helgi I. Ingólfsson, Andrew G. Stephen, Felice C. Lightstone, Sandrasegaram Gnanakaran
Publikováno v:
Biophysical journal. 121(19)
During the activation of mitogen-activated protein kinase (MAPK) signaling, the RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF bind to active RAS at the plasma membrane. The orientation of RAS at the membrane may be critical for forma
Autor:
Mohammad H. Rohban, Ashley M. Fuller, Ceryl Tan, Jonathan T. Goldstein, Deepsing Syangtan, Amos Gutnick, Ann DeVine, Madhura P. Nijsure, Megan Rigby, Joshua R. Sacher, Steven M. Corsello, Grace B. Peppler, Marta Bogaczynska, Andrew Boghossian, Gabrielle E. Ciotti, Allison T. Hands, Aroonroj Mekareeya, Minh Doan, Jennifer P. Gale, Rik Derynck, Thomas Turbyville, Joel D. Boerckel, Shantanu Singh, Laura L. Kiessling, Thomas L. Schwarz, Xaralabos Varelas, Florence F. Wagner, Ran Kafri, T.S. Karin Eisinger-Mathason, Anne E. Carpenter
Identifying chemical regulators of biological pathways is currently a time-consuming bottleneck in developing therapeutics and small-molecule research tools. Typically, thousands to millions of candidate small molecules are tested in target-based bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fa998708d494bc5bb5f98affb1ae7d3
https://doi.org/10.1101/2021.07.29.454377
https://doi.org/10.1101/2021.07.29.454377
Autor:
Subbaya Subramanian, Dwight V. Nissley, Christopher M. Clark, Yevgeniy Romin, Clifford J. Steer, Mihir Shetty, Katia Manova-Todorova, Thomas Turbyville, Emil Lou, Snider Desir, Timothy K. Starr, Phillip Wong, De Chen, Edward Zhai
Publikováno v:
Cancers
Volume 11
Issue 7
Cancers, Vol 11, Iss 7, p 892 (2019)
Volume 11
Issue 7
Cancers, Vol 11, Iss 7, p 892 (2019)
Mutated forms of the RAS oncogene drive 30% of all cancers, but they cannot be targeted therapeutically using currently available drugs. The molecular and cellular mechanisms that create a heterogenous tumor environment harboring both mutant and wild
Autor:
Anne E. Sarver, Drew Sciacca, John Columbus, Dwight V. Nissley, Thomas Turbyville, Andrew C. Nelson, Emil Lou, Bob Stephens, Dhirendra Simanshu, Rendong Yang, Subbaya Subramanian
Publikováno v:
Journal of Clinical Oncology. 37:e15069-e15069
e15069 Background: Recent clinical guidelines for expansion of molecular testing of oncogenic RAS mutations in colorectal carcinoma have led to increased identification of mutations in this patient population. The clinical characteristics of NRAS-mut