Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Thomas Trian"'
Autor:
Benoit Allard, Olga Ousova, Zhanna Savitskaya, Hannah Levardon, Elise Maurat, Marilyne Campagnac, Thomas Trian, Patrick Berger
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background While asthma exacerbations remain a major challenge in patient management, few animal models exist to explore the underlying mechanisms. Here, we established an animal model of asthma that can be used to study pathophysiological m
Externí odkaz:
https://doaj.org/article/c1b8c53d13f542be8cb337dd885642b2
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Autor:
Edmée Eyraud, Elise Maurat, Jean-Marc Sac-Epée, Pauline Henrot, Maeva Zysman, Pauline Esteves, Thomas Trian, Jean-William Dupuy, Alexander Leipold, Antoine-Emmanuel Saliba, Hugues Begueret, Pierre-Olivier Girodet, Matthieu Thumerel, Romain Hustache-Castaing, Roger Marthan, Florian Levet, Pierre Vallois, Cécile Contin-Bordes, Patrick Berger, Isabelle Dupin
Publikováno v:
eLife, Vol 12 (2023)
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contact between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T cells and its consequences were invest
Externí odkaz:
https://doaj.org/article/064e53c85bea4600b8120e56581b253a
Autor:
Pauline Henrot, Edmée Eyraud, Elise Maurat, Sophie Point, Guillaume Cardouat, Jean-François Quignard, Pauline Esteves, Thomas Trian, Pierre-Olivier Girodet, Roger Marthan, Maéva Zysman, Patrick Berger, Isabelle Dupin
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lung function
Externí odkaz:
https://doaj.org/article/308ff3109e1a4a8e98be9283773d1322
Publikováno v:
European Respiratory Review, Vol 29, Iss 157 (2020)
Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence of numerous new avenues of exciting mitochondria-related research including immunometabolism, mitochondrial transplantation and mitochondria-microbe biology.
Externí odkaz:
https://doaj.org/article/74b65d28a2c64ff3a6994835211b361a
Autor:
Benoit Allard, Hannah Levardon, Pauline Esteves, Alexis Celle, Elise Maurat, Matthieu Thumerel, Pierre Olivier Girodet, Thomas Trian, Patrick Berger
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Asthma exacerbations, a major concern in therapeutic strategies, are most commonly triggered by viral respiratory infections, particularly with human rhinovirus (HRV). Infection of bronchial epithelial (BE) cells by HRV triggers inflammation, notably
Externí odkaz:
https://doaj.org/article/6760bee06c7d4360a49dc0b187b9dca3
Publikováno v:
Journal of Asthma and Allergy, Vol 2009, Iss default, Pp 33-42 (2009)
Markus Weckmann1, Thomas Trian1, Brian GG OliverDepartment of Pharmacology, The University of Sydney, Sydney, Australia; Woolcock Institute of Medical Research, Camperdown, NSW-2050, Australia; Bosch Research Institute, University of Sydney, Sydney,
Externí odkaz:
https://doaj.org/article/7e55891f1aee4516968d03fc480b4ee1
Autor:
Benoit Allard, Imane Bara, Guillaume Gilbert, Gabrielle Carvalho, Thomas Trian, Annaig Ozier, Jennifer Gillibert-Duplantier, Olga Ousova, Elise Maurat, Matthieu Thumerel, Jean-François Quignard, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86945 (2014)
Asthmatic bronchial smooth muscle (BSM) is characterized by structural remodeling associated with mast cell infiltration displaying features of chronic degranulation. Mast cell-derived tryptase can activate protease activated receptor type-2 (PAR-2)
Externí odkaz:
https://doaj.org/article/32d3d3639d524853848b27283d297663
Autor:
Thomas Trian, Janette K Burgess, Kyoko Niimi, Lyn M Moir, Qi Ge, Patrick Berger, Stephen B Liggett, Judith L Black, Brian G Oliver
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20000 (2011)
Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism
Externí odkaz:
https://doaj.org/article/294b14fb858d4923bcca8f608b5fb2b8
Bronchial Remodeling-based Latent Class Analysis Predicts Exacerbations in Severe Preschool Wheezers
Autor:
Michael Fayon, Fabien Beaufils, Pauline Esteves, Maryline Campagnac, Elise Maurat, Marine Michelet, Valerie Siao-Him-Fa, Frederic Lavrand, Guillaume Simon, Hugues Begueret, Patrick Berger, Françoise Auriol, Sylvain Blanchon, Dominique Carles, Vincent Boisserie-Lacroix, François Brémont, Stéphanie Bui, Marie-Luce Choukroun, Stéphane Debelleix, Hala Feghali, Géraldine Labouret, Audrey Martin Blondel, Sébastien Marais, Marie Mittaine, Fabienne Nacka, Olga Ousova, Isabelle Rouquette, François Semjen, Frédérique Sgoifo, Thomas Trian
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:416-426
Children with preschool wheezing represent a very heterogeneous population with wide variability regarding their clinical, inflammatory, obstructive, and/or remodeling patterns. We hypothesized that assessing bronchial remodeling would help clinician
Autor:
Fabien Beaufils, Pauline Esteves, Raphael Enaud, Renaud Prevel, Pauline Henrot, Marilyne Campagnac, Elise Maurat, marine michelet, Frederic Lavrand, Hugues Bégueret, Thomas Trian, Michael Fayon, Patrick Berger
INTRODUCTION: Exacerbations in preschool wheezers increase the risk of impaired lung function and asthma persistence at school age. Bronchial remodelling-based latent classes identify severe preschool wheezers at increased risk of frequent exacerbati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2750883cfb28b9800f7588814f85c8
https://doi.org/10.22541/au.168386371.12605715/v1
https://doi.org/10.22541/au.168386371.12605715/v1